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Severe forms of osteogenesis imperfecta (OI) are usually caused by mutations in genes that code for collagen Type I and frequently are associated with craniofacial abnormalities. However, the dental and craniofacial characteristics of OI caused by the p.Ser40Leu mutation in the IFITM5 gene have not been reported. We investigated a 15‐year‐old girl with severe OI caused by this mutation. She had marked deformations of extremity long bones. There were no clinical or radiological signs of dentinogenesis imperfecta, but one tooth was missing and several teeth were impacted. Cone beam computed tomography revealed a generalized osteopenic appearance of the craniofacial skeleton, bilateral enlargement of mandibular bodies, and areas of cortical erosions. The cranial base and skull showed a generalized granular bone pattern with a mixture of osteosclerosis and osteolysis. Sphenoid and frontal sinuses were congenitally missing. Cephalometric analysis indicated a Class III growth pattern. In this case, the IFITM5 p.Ser40Leu mutation did not affect tooth structure but was associated with deformities in craniofacial bones that resemble those in the other parts of the skeleton.  相似文献   
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Proton pump inhibitors (PPIs) have a negative impact on bone accrual. Because osseointegration is influenced by bone metabolism, this study investigates the association between PPIs and the risk of osseointegrated implant failure. This retrospective cohort study included a total of 1,773 osseointegrated dental implants in 799 patients (133 implants in 58 PPIs users and 1,640 in 741 non‐users) who were treated at the East Coast Oral Surgery Clinic in Moncton, Canada, from January 2007 to September 2015. Kaplan‐Meier estimator was used to describe the hazard function of dental implant failure by PPIs usage. Multilevel mixed effects parametric survival analyses were used to test the association between PPIs exposure and risk of implant failure adjusting for potential confounders. The failure rates were 6.8% for people using PPIs compared to 3.2% for non‐users. Subjects using PPIs had a higher risk of dental implant failure (HR = 2.73; 95% CI = 1.10–6.78) compared to those who did not use the drugs. The findings suggest that treatment with PPIs may be associated with an increased risk of osseointegrated dental implant failure.  相似文献   
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The serous detachment of the retina is a rare but serious complication of the severe preeclampsia. It's diagnosis rests on the systematic exam of the eye fundus at the time of the stern shapes of preeclampsia and especially at every change of the visual acuteness. Therefore the observed anomalies must be confirmed by the practice of a retina angiography in the following week. The observation of such complication at the pregnant woman must induce the childbirth who is the only efficient treatment to preserve her visual prognosis. Usually the serous detachment of the retina disappears spontaneously in some days but some visual aftermaths can occurs in cases where papillary edema is prolonged or in cases of macular pigmentary migrations. As for foetal prognosis, it's often reserved.  相似文献   
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Objective

Clasps of removable partial dentures (RPDs) often suffer from plastic deformation and failure by fatigue; a common complication of RPDs. A new technology for processing metal frameworks for dental prostheses based on laser-sintering, which allows for precise fabrication of clasp geometry, has been recently developed. This study sought to propose a novel method for designing circumferential clasps for laser-sintered RPDs to avoid plastic deformation or fatigue failure.

Methods

An analytical model for designing clasps with semicircular cross-sections was derived based on mechanics. The Euler–Bernoulli elastic curved beam theory and Castigliano’s energy method were used to relate the stress and undercut with the clasp length, cross-sectional radius, alloy properties, tooth type, and retention force. Finite element analysis (FEA) was conducted on a case study and the resultant tensile stress and undercut were compared with the analytical model predictions. Pull-out experiments were conducted on laser-sintered cobalt–chromium (Co–Cr) dental prostheses to validate the analytical model results.

Results

The proposed circumferential clasp design model yields results in good agreement with FEA and experiments. The results indicate that Co–Cr circumferential clasps in molars that are 13 mm long engaging undercuts of 0.25 mm should have a cross-section radius of 1.2 mm to provide a retention of 10 N and to avoid plastic deformation or fatigue failure. However, shorter circumferential clasps such as those in premolars present high stresses and cannot avoid plastic deformation or fatigue failure.

Significance

Laser-sintered Co–Cr circumferential clasps in molars are safe, whereas they are susceptible to failure in premolars.  相似文献   
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