全文获取类型
收费全文 | 2222篇 |
免费 | 145篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 50篇 |
妇产科学 | 40篇 |
基础医学 | 295篇 |
口腔科学 | 248篇 |
临床医学 | 209篇 |
内科学 | 392篇 |
皮肤病学 | 41篇 |
神经病学 | 189篇 |
特种医学 | 34篇 |
外科学 | 181篇 |
综合类 | 8篇 |
一般理论 | 2篇 |
预防医学 | 297篇 |
眼科学 | 19篇 |
药学 | 116篇 |
中国医学 | 11篇 |
肿瘤学 | 220篇 |
出版年
2024年 | 3篇 |
2023年 | 30篇 |
2022年 | 53篇 |
2021年 | 68篇 |
2020年 | 69篇 |
2019年 | 64篇 |
2018年 | 81篇 |
2017年 | 66篇 |
2016年 | 69篇 |
2015年 | 82篇 |
2014年 | 83篇 |
2013年 | 108篇 |
2012年 | 194篇 |
2011年 | 181篇 |
2010年 | 108篇 |
2009年 | 97篇 |
2008年 | 133篇 |
2007年 | 154篇 |
2006年 | 124篇 |
2005年 | 118篇 |
2004年 | 105篇 |
2003年 | 73篇 |
2002年 | 67篇 |
2001年 | 36篇 |
2000年 | 34篇 |
1999年 | 28篇 |
1998年 | 10篇 |
1997年 | 3篇 |
1996年 | 6篇 |
1995年 | 9篇 |
1994年 | 4篇 |
1993年 | 10篇 |
1992年 | 11篇 |
1991年 | 7篇 |
1990年 | 11篇 |
1989年 | 5篇 |
1988年 | 5篇 |
1987年 | 8篇 |
1986年 | 8篇 |
1985年 | 5篇 |
1984年 | 9篇 |
1983年 | 3篇 |
1981年 | 2篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 2篇 |
1973年 | 2篇 |
1970年 | 4篇 |
1969年 | 4篇 |
排序方式: 共有2371条查询结果,搜索用时 15 毫秒
31.
Ana Dorcas de Melo Inagaki Cristina Gardonyi Carvalheiro Rosana Cipolotti Ricardo Queiroz Gurgel Dayse Alves Rocha Kariny Souza Pinheiro Raquel Melo Araújo Dorothy Ribeiro Resende Lima Jacques Leon Winandy Marisa Márcia Mussi‐Pinhata 《Tropical medicine & international health : TM & IH》2012,17(11):1349-1355
Objectives To estimate, by neonatal screening, the birth prevalence of congenital toxoplasmosis among live‐born infants in Sergipe state, Brazil, and to investigate the clinical features of affected infants. Methods Dried blood spot specimens obtained from 15 204 neonates were assayed for the presence of anti‐T. gondii IgM antibodies. Duplicate retesting was done in infants with positive and borderline results. Confirmatory testing in peripheral blood samples consisted of testing for anti‐T. gondii IgG and IgM in infants and mothers. Those with possible congenital toxoplasmosis were evaluated and followed up to a median age of 20 months. Congenital infection was confirmed in the presence of persisting anti‐T. gondii IgG antibodies beyond 12 months of age. All infants with confirmed infection were treated with pyrimethamine, sulfadiazine and folinic acid for 1 year. Results Fifty‐three infants had detectable IgM in dried blood spot specimens. Confirmatory testing was reactive in 39/50, of which, 38 completed follow‐up. Six of 15 204 newborns were diagnosed with congenital toxoplasmosis, resulting in an estimated birth prevalence of four per 10 000 [CI 95% 1.4–8.0]. Four infants (67%) showed signs of congenital toxoplasmosis in their first year of life; three (75%) had retinochoroidal scars, and one had cerebral calcifications. Two infants remained asymptomatic until 20 months of age. Conclusions The birth prevalence of congenital toxoplasmosis is high in the Brazilian state of Sergipe, with most of the infants showing ocular lesions. Preventive measures are strongly warranted. 相似文献
32.
P. H. E. Arruda B. L. Arruda K. J. Schwartz F. Vannucci T. Resende A. Rovira P. Sundberg J. Nietfeld B. M. Hause 《Transboundary and Emerging Diseases》2017,64(2):311-315
An approximately 3,000 finishing swine operation in the United States experienced an outbreak of an atypical neurologic disease in 11‐weeks‐old pigs with an overall morbidity of 20% and case fatality rate of 30%. The clinical onset and progression of signs in affected pigs varied but included inappetence, compromised ambulation, ataxia, incoordination, mental dullness, paresis, paralysis and decreased response to environmental stimuli. Tissues from affected pigs were submitted for diagnostic investigation. Histopathologic examination of the cerebrum, cerebellum and spinal cord revealed severe lymphoplasmacytic and necrotizing polioencephalomyelitis with multifocal areas of gliosis and neuron satellitosis, suggestive of a neurotropic viral infection. Bacterial pathogens were not isolated by culture of neurologic tissue from affected pigs. Samples tested by polymerase chain reaction (PCR) were negative for pseudorabies virus and atypical porcine pestivirus. Immunohistochemistry for porcine reproductive and respiratory syndrome virus, porcine circovirus and Listeria was negative. Porcine sapelovirus (PSV) was identified in spinal cord by a nested PCR used to detect porcine enterovirus, porcine teschovirus and PSV. Next‐generation sequencing of brainstem and spinal cord samples identified PSV and the absence of other or novel pathogens. In addition, Sapelovirus A mRNA was detected in neurons and nerve roots of the spinal cord by in situ hybridization. The PSV is genetically novel with an overall 94% amino acid identity and 86% nucleotide identity to a recently reported sapelovirus from Korea. This is the first case report in the United States associating sapelovirus with severe polioencephalomyelitis in pigs. 相似文献
33.
Childhood socioeconomic conditions and teeth in older adulthood: Evidence from SHARE wave 5
下载免费PDF全文
![点击此处可从《Community dentistry and oral epidemiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
34.
35.
DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus
下载免费PDF全文
![点击此处可从《Journal of oral pathology & medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Aline Fernanda Cruz Renata Gonçalves de Resende Júlio César Tanos de Lacerda Núbia Braga Pereira Leonardo Augusto Melo Marina Gonçalves Diniz Carolina Cavalieri Gomes Ricardo Santiago Gomez 《Journal of oral pathology & medicine》2018,47(1):91-95
Background
The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune‐mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response‐related genes in the different clinical forms of oral lichen planus.Methods
A cross‐sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation‐sensitive and methylation‐dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real‐time polymerase chain reaction arrays.Results
Hypermethylation of the STAT5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%).Conclusion
Our results show variations in the methylation profile of immune response‐related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis. 相似文献36.
37.
38.
39.
Gilberg Resende Viana DDS Ana Paula Teiltelbaum PhD Fábio André dos Santos PhD Aida Sabbagh‐Haddad PhD Renata Oliveira Guaré PhD 《Special care in dentistry》2014,34(6):286-290
The aim of this study was to evaluate the clinical effectiveness of .12% chlorhexidine applied via spray and the acceptance. A total of 26 individuals with mental health issues, aged 7–14, were included into two groups: placebo (control, n = 13) and chlorhexidine (experimental, n = 13). Both groups received two daily applications of spray during 2 months. The periodontal conditions were evaluated by the simplified oral hygiene index (OHI‐S) and gingival index (GI). The evaluation of acceptance of the application method (spray) was assessed by questionnaire. Data were analyzed with nonparametric tests, with a significance level of 5%. Regarding the OHI‐S index, only the experimental group showed significant change during the evaluations (p < 0.001). Regarding the GI, both groups showed significant changes during the evaluations. The method of application was well accepted by patients and caregivers, and .12% chlorhexidine solution applied via spray significantly reduced the rates of dental and gingival biofilm. 相似文献
40.
Jules Rimet Borges Bárbara Álvares Salum Ximenes Flávia Tandaya Grandi Miranda Giordana Bruna Moreira Peres Isabella Toscano Hayasaki Luiz César de Camargo Ferro Mayra Ianhez Marco Tulio Antonio Garcia-Zapata 《Anais brasileiros de dermatologia》2022,97(4):424-434
BackgroundChromoblastomycosis is a skin infection caused by dematiaceous fungi that take the form of muriform cells in the tissue. It mainly manifests as verrucous plaques on the lower limbs of rural workers in tropical countries.ObjectivesThe primary objective of this review is to evaluate the accuracy of diagnostic methods for the identification of chromoblastomycosis, considering the histopathological examination as the reference test.MethodsMEDLINE, LILACS and Scielo databases were consulted using the terms “chromoblastomycosis” AND “diagnosis”. The eligibility criteria were: studies that evaluated the accuracy of tests for the diagnosis of chromoblastomycosis. Eleven studies were selected. Statistical analysis included the calculation of sensitivity and specificity of the diagnostic methods.ResultsConsidering the histopathological examination as the reference test, the culture showed a sensitivity (S) of 37.5% - 90.9% and a specificity (Sp) of 100%; while direct mycological examination showed S = 50% - 91.6% and Sp of 100% . Considering the culture as the reference test, the serology (precipitation techniques) showed S of 36% - 99%; and Sp of 80% - 100%; while the intradermal test showed S of 83.3% - 100% and Sp of 99.4% - 100%.Study limitationsThe small number of studies and very discrepant sensitivity results among them do not allow the calculation of summary measures through a meta-analysis.ConclusionsDirect mycological examination, culture, intradermal test and serology show sensitivity and specificity values ??for the diagnosis of chromoblastomycosis with no significant difference between the studies. 相似文献