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Diogo N.M. Gouveia Michael E. Razzoog Maria F. Alfaro 《The Journal of prosthetic dentistry》2019,121(4):571-575
The use of a fully digital approach to fabricate an anatomic contour crown to fit an existing removable prosthesis allows the dentist and the dental laboratory technician to work efficiently in a digital environment. This report presents a series of patient treatments involving the fabrication of an anatomic contour monolithic zirconia crown to retrofit an existing removable partial denture. A complete digital workflow comprises an intraoral digital scan and computer-aided design and computer-aided manufacturing (CAD-CAM) technology. 相似文献
64.
Rodrigo Staggemeier Diogo André Pilger Fernando Rosado Spilki Vlademir Vicente Cantarelli 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(2):93-95
A novel SYBR® green-real time polymerase chain reaction
(qPCR) was developed to detect two Bartonella species,
B. henselae and B. clarridgeiae, directly
from blood samples. The test was used in blood samples obtained from cats living
in animal shelters in Southern Brazil. Results were compared with those obtained
by conventional PCR targeting Bartonella spp. Among the 47
samples analyzed, eight were positive using the conventional PCR and 12 were
positive using qPCR. Importantly, the new qPCR detected the presence of both
B. henselae and B. clarridgeiae in two
samples. The results show that the qPCR described here may be a reliable tool
for the screening and differentiation of two important
Bartonella species. 相似文献
65.
Alexsandra R.m. Favacho Isabelle Roger Amanda K. Akemi Adonai A. Pessoa JR. Andrea G. Varon Raphael Gomes Daniela T. Godoy Sandro Pereira Elba R.s. Lemos 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(4):363-365
Bartonella henselae is associated with a wide spectrum of clinical
manifestations, including cat scratch disease, endocarditis and meningoencephalitis,
in immunocompetent and immunocompromised patients. We report the first molecularly
confirmed case of B. henselae infection in an AIDS patient in state
of Rio de Janeiro, Brazil. Although DNA sequence of B. henselae has
been detected by polymerase chain reaction in a lymph node biopsy, acute and
convalescent sera were nonreactive. 相似文献
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Volkmer JP Sahoo D Chin RK Ho PL Tang C Kurtova AV Willingham SB Pazhanisamy SK Contreras-Trujillo H Storm TA Lotan Y Beck AH Chung BI Alizadeh AA Godoy G Lerner SP van de Rijn M Shortliffe LD Weissman IL Chan KS 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(6):2078-2083
Current clinical judgment in bladder cancer (BC) relies primarily on pathological stage and grade. We investigated whether a molecular classification of tumor cell differentiation, based on a developmental biology approach, can provide additional prognostic information. Exploiting large preexisting gene-expression databases, we developed a biologically supervised computational model to predict markers that correspond with BC differentiation. To provide mechanistic insight, we assessed relative tumorigenicity and differentiation potential via xenotransplantation. We then correlated the prognostic utility of the identified markers to outcomes within gene expression and formalin-fixed paraffin-embedded (FFPE) tissue datasets. Our data indicate that BC can be subclassified into three subtypes, on the basis of their differentiation states: basal, intermediate, and differentiated, where only the most primitive tumor cell subpopulation within each subtype is capable of generating xenograft tumors and recapitulating downstream populations. We found that keratin 14 (KRT14) marks the most primitive differentiation state that precedes KRT5 and KRT20 expression. Furthermore, KRT14 expression is consistently associated with worse prognosis in both univariate and multivariate analyses. We identify here three distinct BC subtypes on the basis of their differentiation states, each harboring a unique tumor-initiating population. 相似文献
68.
Bortoluzzi MC Passador-Santos F Capella DL Manfro G Nodari RJ Presta AA 《Annali di stomatologia》2012,3(1):11-13
Eosinophilic Ulcer (EU) is a rare self-limiting chronic benign lesion of the oral mucosa with pathogenesis still unclear, however it may resemble malignancies, traumatic ulcerations and some infections such as deep fungal infections, tuberculosis and primary syphilis. This is a case report of a patient with EU in the lateral border of the tongue with no history of associated trauma and refractory to treatment with drugs. The ulcer rapidly healed after an incisional biopsy and the definite diagnosis was achieved only combining histologic findings and the clinical follow-up. 相似文献
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Nils Henninger Diogo C. Haussen Nikolaos Kakouros Magdy Selim D. Eric Searls Sandeep Kumar Gottfried Schlaug Louis R. Caplan 《Neurocritical care》2013,19(2):167-175