全文获取类型
收费全文 | 1624695篇 |
免费 | 128054篇 |
国内免费 | 4117篇 |
专业分类
耳鼻咽喉 | 20807篇 |
儿科学 | 52161篇 |
妇产科学 | 45119篇 |
基础医学 | 228474篇 |
口腔科学 | 41774篇 |
临床医学 | 147890篇 |
内科学 | 329012篇 |
皮肤病学 | 36318篇 |
神经病学 | 137519篇 |
特种医学 | 60838篇 |
外国民族医学 | 472篇 |
外科学 | 242060篇 |
综合类 | 35842篇 |
现状与发展 | 3篇 |
一般理论 | 785篇 |
预防医学 | 128665篇 |
眼科学 | 37157篇 |
药学 | 113292篇 |
7篇 | |
中国医学 | 3642篇 |
肿瘤学 | 95029篇 |
出版年
2021年 | 15362篇 |
2019年 | 16036篇 |
2018年 | 21521篇 |
2017年 | 16398篇 |
2016年 | 18357篇 |
2015年 | 20784篇 |
2014年 | 29771篇 |
2013年 | 43337篇 |
2012年 | 60412篇 |
2011年 | 63631篇 |
2010年 | 37051篇 |
2009年 | 34988篇 |
2008年 | 58317篇 |
2007年 | 61629篇 |
2006年 | 62017篇 |
2005年 | 60445篇 |
2004年 | 57540篇 |
2003年 | 54510篇 |
2002年 | 52149篇 |
2001年 | 74853篇 |
2000年 | 75964篇 |
1999年 | 63588篇 |
1998年 | 19592篇 |
1997年 | 17624篇 |
1996年 | 17391篇 |
1995年 | 16562篇 |
1994年 | 14924篇 |
1993年 | 13921篇 |
1992年 | 46942篇 |
1991年 | 44475篇 |
1990年 | 42374篇 |
1989年 | 40414篇 |
1988年 | 37058篇 |
1987年 | 36205篇 |
1986年 | 33706篇 |
1985年 | 32141篇 |
1984年 | 24920篇 |
1983年 | 21032篇 |
1982年 | 13417篇 |
1981年 | 11923篇 |
1979年 | 21323篇 |
1978年 | 15248篇 |
1977年 | 12659篇 |
1976年 | 11875篇 |
1975年 | 12032篇 |
1974年 | 14411篇 |
1973年 | 13893篇 |
1972年 | 12955篇 |
1971年 | 11730篇 |
1970年 | 11128篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
J.-P. Ortonne A. Taïeb A.D. Ormerod† D. Robertson‡ J. Foehl‡ R. Pedersen‡ C. Molta‡ B. Freundlich‡ 《The British journal of dermatology》2009,161(5):1190-1195
Background Patients with psoriasis experience remission and gradual reappearance of erythematous and scaly plaques and require individualized treatment over time. A goal of psoriasis treatment is to provide optimal efficacy with a flexible therapeutic regimen that may include treatment pauses.
Objectives To determine whether patients receiving initial treatment with etanercept who then pause therapy would subsequently recapture response during re-treatment.
Patients and methods A post-hoc analysis of 226 patients with moderate-to-severe psoriasis from a large multicentre trial was performed. Patients had received etanercept 50 mg twice weekly subcutaneously until a target clinical response had been achieved, then had paused treatment and eventually relapsed. They were then re-treated with etanercept 25 mg twice weekly. The number of patients recapturing a Physician Global Assessment (PGA) of psoriasis rating of ≤ 2 (clear, almost clear or mild) on first re-treatment was assessed. Patient satisfaction during the initial treatment and first re-treatment period was also determined.
Results A total of 187 (83%) patients recaptured the target clinical response of a PGA of ≤ 2 after re-treatment. The majority of patients [219 of 226 (97%)] reported satisfaction with etanercept re-treatment. No new safety concerns emerged during re-treatment.
Conclusions In this post-hoc analysis, patients with psoriasis who were re-treated with etanercept 25 mg twice weekly effectively recaptured clinical responses that patients found satisfactory. A flexible treatment option is available to dermatologists and patients for individualized care. 相似文献
Objectives To determine whether patients receiving initial treatment with etanercept who then pause therapy would subsequently recapture response during re-treatment.
Patients and methods A post-hoc analysis of 226 patients with moderate-to-severe psoriasis from a large multicentre trial was performed. Patients had received etanercept 50 mg twice weekly subcutaneously until a target clinical response had been achieved, then had paused treatment and eventually relapsed. They were then re-treated with etanercept 25 mg twice weekly. The number of patients recapturing a Physician Global Assessment (PGA) of psoriasis rating of ≤ 2 (clear, almost clear or mild) on first re-treatment was assessed. Patient satisfaction during the initial treatment and first re-treatment period was also determined.
Results A total of 187 (83%) patients recaptured the target clinical response of a PGA of ≤ 2 after re-treatment. The majority of patients [219 of 226 (97%)] reported satisfaction with etanercept re-treatment. No new safety concerns emerged during re-treatment.
Conclusions In this post-hoc analysis, patients with psoriasis who were re-treated with etanercept 25 mg twice weekly effectively recaptured clinical responses that patients found satisfactory. A flexible treatment option is available to dermatologists and patients for individualized care. 相似文献
992.
L.A. Fischer T. Menné C. Avnstorp G.B. Kasting† J.D. Johansen† 《The British journal of dermatology》2009,161(3):560-567
Background Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) is a synthetic fragrance ingredient. Case reports of allergy to HICC appeared in the 1980s, and HICC has recently been included in the European baseline series. Human elicitation dose–response studies performed with different allergens have shown a significant relationship between the patch-test threshold and the repeated open application test (ROAT) threshold, which mimics some real-life exposure situations. Fragrance ingredients are special as significant amounts of allergen may evaporate from the skin.
Objectives The study aimed to investigate the relationship between elicitation threshold doses at the patch test and the ROAT, using HICC as the allergen. The expected evaporation rate was calculated.
Materials and methods Seventeen HICC-allergic persons were tested with a dilution series of HICC in a patch test and a ROAT (duration up to 21 days). Seventeen persons with no HICC allergy were included as control group for the ROAT.
Results The response frequency to the ROAT (in μg HICC cm−2 per application) was significantly higher than the response frequency to the patch test at one of the tested doses. Furthermore the response rate to the accumulated ROAT dose was significantly lower at half of the doses compared with the patch test. The evaporation rate of HICC was calculated to be 72% over a 24-h period.
Conclusions The ROAT threshold in dose per area per application is lower than the patch test threshold; furthermore the accumulated ROAT threshold is higher than the patch test threshold, which can probably be explained by the evaporation of HICC from the skin in the open test. 相似文献
Objectives The study aimed to investigate the relationship between elicitation threshold doses at the patch test and the ROAT, using HICC as the allergen. The expected evaporation rate was calculated.
Materials and methods Seventeen HICC-allergic persons were tested with a dilution series of HICC in a patch test and a ROAT (duration up to 21 days). Seventeen persons with no HICC allergy were included as control group for the ROAT.
Results The response frequency to the ROAT (in μg HICC cm
Conclusions The ROAT threshold in dose per area per application is lower than the patch test threshold; furthermore the accumulated ROAT threshold is higher than the patch test threshold, which can probably be explained by the evaporation of HICC from the skin in the open test. 相似文献
993.
994.
995.
996.
997.
998.
999.
1000.