补肺活血法治疗慢性阻塞性肺疾病缓解期患者的临床观察

目的 研究补肺活血法治疗慢性阻塞性肺疾病缓解期的临床疗效和对肺功能的影响.方法 将125例患者随机分为治疗组85例和对照组40例,两组均经缓解期常规基础治疗,治疗组加用中药汤剂口服.两组均以2周为1个疗程,连续治疗4个疗程后统计疗效.结果 治疗组总有效率为94.1%,对照组总有效率为90.0%,两组相比,P＜0.05;两组的主要症状和体征均改善,但治疗组对咳嗽、咳痰、喘促、气短以及肺部罗音等症状体征改善均优于对照组(P＜0.01);治疗组的肺功能的改善优于对照组(P＜0.05);治疗组的发病次数明显少于对照组(P＜0.05).结论 补肺活血法能有效改善慢性阻塞性肺疾病缓解期患者的临床症状、体征、肺功能,减少患者发病次数,并提高其生活质量.     

Propoxur-induced oxidative DNA damage in human peripheral blood mononuclear cells: protective effects of curcumin and α-tocopherol

The present study enumerates the attenuating effects of curcumin and α-tocopherol against propoxur induced oxidative DNA damage in human peripheral blood mononuclear cells (PBMC). Cultured cells were isolated from peripheral blood of healthy volunteers, and were exposed to varying concentrations of propoxur (0–21?μg/ml) for 6, 12, and 24?h, and in combination with curcumin (9.2?μg/ml) or α-tocopherol (4.3?μg/ml) or both. Cytotoxic effect of propoxur was examined by MTT assay. The role of oxidative stress beneath the cytotoxicity of propoxur was evaluated by the measurement of reduced glutathione (GSH), malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine (8-OH-dG) levels in cell lysate. A concentration-dependent cell death, depletion of GSH, an increase in the level of both MDA and 8-OH-dG were observed. Co-treatment with curcumin or α-tocopherol significantly attenuates depleted GSH, decrease in MDA and 8-OH-dG levels in propoxur exposed cells (p?相似文献   

A comparison between the effects of ochratoxin A and aristolochic acid on the inflammation and oxidative stress in the liver and kidney of weanling piglets

Naunyn-Schmiedeberg's Archives of Pharmacology - Ochratoxin A (OTA) and aristolochic acid (AA) are toxins that can frequently contaminate cereals and cereals-based products. The present study...