全文获取类型
收费全文 | 2644篇 |
免费 | 231篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 64篇 |
妇产科学 | 62篇 |
基础医学 | 478篇 |
口腔科学 | 75篇 |
临床医学 | 271篇 |
内科学 | 541篇 |
皮肤病学 | 38篇 |
神经病学 | 211篇 |
特种医学 | 58篇 |
外科学 | 425篇 |
综合类 | 15篇 |
一般理论 | 1篇 |
预防医学 | 204篇 |
眼科学 | 20篇 |
药学 | 169篇 |
中国医学 | 1篇 |
肿瘤学 | 235篇 |
出版年
2023年 | 14篇 |
2022年 | 25篇 |
2021年 | 47篇 |
2020年 | 59篇 |
2019年 | 69篇 |
2018年 | 67篇 |
2017年 | 55篇 |
2016年 | 61篇 |
2015年 | 64篇 |
2014年 | 85篇 |
2013年 | 121篇 |
2012年 | 169篇 |
2011年 | 160篇 |
2010年 | 94篇 |
2009年 | 99篇 |
2008年 | 148篇 |
2007年 | 128篇 |
2006年 | 152篇 |
2005年 | 122篇 |
2004年 | 136篇 |
2003年 | 119篇 |
2002年 | 117篇 |
2001年 | 48篇 |
2000年 | 48篇 |
1999年 | 59篇 |
1998年 | 25篇 |
1997年 | 30篇 |
1996年 | 15篇 |
1995年 | 20篇 |
1994年 | 27篇 |
1993年 | 13篇 |
1992年 | 31篇 |
1991年 | 37篇 |
1990年 | 30篇 |
1989年 | 28篇 |
1988年 | 25篇 |
1987年 | 36篇 |
1986年 | 34篇 |
1985年 | 25篇 |
1984年 | 19篇 |
1983年 | 16篇 |
1982年 | 15篇 |
1979年 | 14篇 |
1977年 | 14篇 |
1976年 | 12篇 |
1974年 | 12篇 |
1970年 | 15篇 |
1969年 | 11篇 |
1967年 | 12篇 |
1966年 | 18篇 |
排序方式: 共有2890条查询结果,搜索用时 140 毫秒
51.
Christel Lenz 《Zeitschrift für Psychodrama und Soziometrie》2013,11(1):181-193
Based on theoretical considerations and case reports, possibilities of scenic work with the life line are presented. It is obvious how clients, already in the initial phase of their therapy, are supported in perceiving themselves as “actors on the stages of their lives”. The scenic experiencing of longitudinal and cross sections on the life line enables clients to create a “subjective theory of disease”. Treatment goals become apparent and can be communicated with respect to a treatment planning. When the addiction can be experienced as history and clients can recognize meaningful correlations on their life lines, motivation and at the same time expectation of self-efficacy for the next steps on their paths through life arises. In psychodramatic work with life lines, anamnesis and diagnostics are closely related to the supporting of the experience of identity, appreciation and meaningfulness. 相似文献
52.
Sinikka Pelkonen Susanne B. Lindahl P?ivi Suomala Jari Karhukorpi Sakari Vuorinen Irma Koivula Tia V?is?nen Jaana Pentik?inen Tiina Autio Tamara Tuuminen 《Emerging infectious diseases》2013,19(7):1041-1048
Streptococcus equi subspecies zooepidemicus (S. zooepidemicus) is a zoonotic pathogen for persons in contact with horses. In horses, S. zooepidemicus is an opportunistic pathogen, but human infections associated with S. zooepidemicus are often severe. Within 6 months in 2011, 3 unrelated cases of severe, disseminated S. zooepidemicus infection occurred in men working with horses in eastern Finland. To clarify the pathogen’s epidemiology, we describe the clinical features of the infection in 3 patients and compare the S. zooepidemicus isolates from the human cases with S. zooepidemicus isolates from horses. The isolates were analyzed by using pulsed-field gel electrophoresis, multilocus sequence typing, and sequencing of the szP gene. Molecular typing methods showed that human and equine isolates were identical or closely related. These results emphasize that S. zooepidemicus transmitted from horses can lead to severe infections in humans. As leisure and professional equine sports continue to grow, this infection should be recognized as an emerging zoonosis. 相似文献
53.
54.
55.
56.
Delphine Payros Thomas Secher Michèle Boury Camille Brehin Sandrine Ménard Christel Salvador-Cartier Gabriel Cuevas-Ramos Claude Watrin Ingrid Marcq Jean-Philippe Nougayrède Damien Dubois Antoine Bedu Fabien Garnier Olivier Clermont Erick Denamur Pascale Plaisancié Vassilia Theodorou Jean Fioramonti Ma?wenn Olier Eric Oswald 《Gut microbes》2014,5(3):313-325
The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coli strains among which a large proportion produces a genotoxin called colibactin. In order to analyze the short- and long-term effects resulting from such evolution, we developed a rat model mimicking the natural transmission of E. coli from mothers to neonates. Genotoxic and non-genotoxic E. coli strains were equally transmitted to the offspring and stably colonized the gut across generations. DNA damage was only detected in neonates colonized with genotoxic E. coli strains. Signs of genotoxic stress such as anaphase bridges, higher occurrence of crypt fission and accelerated renewal of the mature epithelium were detected at adulthood. In addition, we observed alterations of secretory cell populations and gut epithelial barrier. Our findings illustrate how critical is the genotype of E. coli strains acquired at birth for gut homeostasis at adulthood. 相似文献
57.
Charlotte M Höög Olle Broström Tomas L Lindahl Andreas Hillarp Gerd Lärfars Urban Sjöqvist 《BMC gastroenterology》2010,10(1):113
Background
Angioectasias in the gastrointestinal tract can be found in up to 3% of the population. They are typically asymptomatic but may sometimes result in severe bleeding. The reasons for why some patients bleed from their angioectasias are not fully understood but it has been reported that it may be explained by an acquired von Willebrand syndrome (AVWS). This condition has similar laboratory findings to congenital von Willebrand disease with selective loss of large von Willebrand multimers. The aim of this study was to find out if AVWS or any other bleeding disorder was more common in patients with bleeding from angioectasias than in a control group. 相似文献58.
BACKGROUND: Sphincter pharyngoplasty (SP) appears to be the more "physiologic" surgical technique to treat velopharyngeal incompetence (VPI). This procedure creates a dynamic sphincter of variable diameter and keeps the flexibility of the soft palate. SP also induces velopharyngeal size reduction, mainly in the transverse diameter, which may cause upper airway (UA) occlusions during sleep. AIM: To prospectively evaluate the effects of SP by a modified Orticochea procedure on sleep structure and sleep respiratory disturbances. METHODS: Polysomnographic studies before and after surgery in 17 consecutive patients treated by a modified Orticochea procedure SP for VPI. RESULTS: For the whole group, SP did not induce significant impairment of apnea-hypopnea index or nocturnal oxygen saturation. Slow-wave sleep (SWS) was significantly reduced after surgery (25 +/- 9% of total sleep time [TST] vs 28 +/- 9% of TST before SP [p = 0.04]). Following surgery, there was a trend for an increase in the microarousal index) (p = 0.09) and more specifically in respiratory-related microarousals. CONCLUSION: SP, although creating a clinically obvious reduction of velopharyngeal diameter, generally did not lead to the occurrence of an obstructive sleep apnea syndrome. However, we found a significant reduction of SWS quantity and a trend toward an increase in the number of cortical microarousals. These findings suggest that the reduction of UA diameter associated with the surgical technique leads to increases in respiratory effort sufficient to induce sleep fragmentation and SWS reduction, even in the absence of apneas or hypopneas. 相似文献
59.
60.
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Li JP Galvis ML Gong F Zhang X Zcharia E Metzger S Vlodavsky I Kisilevsky R Lindahl U 《Proceedings of the National Academy of Sciences of the United States of America》2005,102(18):6473-6477
Amyloid diseases encompass >20 medical disorders that include amyloid protein A (AA) amyloidosis, Alzheimer's disease, and type 2 diabetes. A common feature of these conditions is the selective organ deposition of disease-specific fibrillar proteins, along with the sulfated glycosaminoglycan, heparan sulfate. We have generated transgenic mice that overexpress human heparanase and have tested their susceptibility to amyloid induction. Drastic shortening of heparan sulfate chains was observed in heparanase-overproducing organs, such as liver and kidney. These sites selectively escaped amyloid deposition on experimental induction of inflammation-associated AA amyloidosis, as verified by lack of material staining with Congo Red, as well as lack of associated polysaccharide, whereas the same tissues from control animals were heavily infiltrated with amyloid. By contrast, the spleens of transgenic mice that failed to significantly overexpress heparanase contained heparan sulfate chains similar in size to those of control spleen and remained susceptible to amyloid deposition. Our findings provide direct in vivo evidence that heparan sulfate is essential for the development of amyloid disease. 相似文献