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Peristera Paschou Dongmei Yu Gloria Gerber Patrick Evans Fotis Tsetsos Lea K. Davis Iordanis Karagiannidis Jonathan Chaponis Eric Gamazon Kirsten Mueller‐Vahl Manfred Stuhrmann Monika Schloegelhofer Mara Stamenkovic Johannes Hebebrand Markus Noethen Peter Nagy Csaba Barta Zsanett Tarnok Renata Rizzo Christel Depienne Yulia Worbe Andreas Hartmann Danielle C. Cath Cathy L. Budman Paul Sandor Cathy Barr Thomas Wolanczyk Harvey Singer I‐Ching Chou Marco Grados Danielle Posthuma Guy A. Rouleau Harald Aschauer Nelson B. Freimer David L. Pauls Nancy J. Cox Carol A. Mathews Jeremiah M. Scharf 《Annals of neurology》2014,76(2):310-315
Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10−3) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry‐matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10−4) remained significant after Bonferroni correction. Meta‐analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10−7). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case–control status (p = 0.042), suggesting that many of these variants are true TS risk alleles. Ann Neurol 2014;76:310–315 相似文献
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Niloufar Dusch Christel Weiss Philip Ströbel Peter Kienle Stefan Post Marco Niedergethmann 《Journal of gastrointestinal surgery》2014,18(4):674-681
Background
Long-term survival after resection for pancreas carcinoma has rarely been reported. Factors influencing long-term survival are still under debate. The aim of this study was to define predictors for long-term survival.Methods
Between 1972 and 2004, a total of 415 patients underwent resection. Data were collected in a prospective data base. Data of 360 patients were available for further analysis in 2011. All specimens of long-term survivors were histologically reviewed.Results
Long-term survivors (n?=?69) had a median survival of 91 months. Pathological re-evaluation of all specimens re-confirmed the diagnosis. Predictive factors for long-term survival in univariate analysis were no preoperative biliary stent, low CA 19-9 level, lack of blood transfusion, R0 resection, tumour diameter, and -grading, absence of lymph node or distant metastases, lymphangiosis, and perineural infiltration. Adjuvant chemotherapy showed a significant influence on overall survival but not on long-term survival. In multivariate analysis, lymph node ratio and volume of blood transfusion were predictors of long-term survival.Conclusion
Nearly 20 % of patients with pancreas carcinoma who undergo surgical resection have a chance of long-term survival. Survival beyond 5 years is predicted by clinical and tumour-specific factors. Adjuvant chemotherapy might prolong overall survival but is, according to these results, unable to contribute to long-term survival. There is still a risk of recurrence after a 5- or even a 12-year mark. Survival beyond 5 or even 12 years, therefore, does not assure cure. 相似文献55.
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Cell and chloroplast division requires ARTEMIS 总被引:10,自引:0,他引:10
Fulgosi H Gerdes L Westphal S Glockmann C Soll J 《Proceedings of the National Academy of Sciences of the United States of America》2002,99(17):11501-11506
Chloroplasts are endosymbiotic organelles of cyanobacterial origin. It seems reasonable to assume that cell division and organelle division still share general principles, as shown for the FtsZ proteins. However, further components involved in this process are largely unknown. Here we describe ARTEMIS, a nuclear-encoded protein of chloroplast inner envelope membranes that is required for organelle division. ARTEMIS consists of three distinct modules: an N-terminal receptor-like region, a centrally positioned glycine-rich stretch containing a nucleoside triphosphate-binding site, and a C-terminal YidC/Oxa1p/Alb3 protein translocase-like domain. Analysis of Arabidopsis En-1 transposon mutants as well as ARTEMIS antisense plants revealed chloroplasts arrested in the late stages of division. Chloroplasts showed clearly separated and distinct multiple thylakoid systems, whereas the final organelle fission remained unaccomplished. Inactivation of a cyanobacterial gene with sequence similarity to the YidC/Oxa1p/Alb3-like domain of ARTEMIS resulted in aberrant cell division, which could be rescued by the Arabidopsis protein. ARTEMIS represents a so-far-unrecognized link between prokaryotic cell fission and chloroplast division. 相似文献
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Fleur Berenschot Marcel A. G. van Aken Christel Hessels Bram Orobio de Castro Ysbrand Pijl Barbara Montagne Guus van Voorst 《European child & adolescent psychiatry》2014,23(7):563-570
It has been argued that a heightened emotional sensitivity interferes with the cognitive processing of facial emotion recognition and may explain the intensified emotional reactions to external emotional stimuli of adults with personality pathology, such as borderline personality disorder (BPD). This study examines if and how deviations in facial emotion recognition also occur in adolescents with personality pathology. Forty-two adolescents with personality pathology, 111 healthy adolescents and 28 psychiatric adolescents without personality pathology completed the Emotion Recognition Task, measuring their accuracy and sensitivity in recognizing positive and negative emotion expressions presented in several, morphed, expression intensities. Adolescents with personality pathology showed an enhanced recognition accuracy of facial emotion expressions compared to healthy adolescents and clients with various Axis-I psychiatric diagnoses. They were also more sensitive to less intensive expressions of emotions than clients with various Axis-I psychiatric diagnoses, but not more than healthy adolescents. As has been shown in research on adults with BPD, adolescents with personality pathology show enhanced facial emotion recognition. 相似文献
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Claudio Peter Rachel Müller Alarcos Cieza Marcel W. M. Post Christel M. C. van Leeuwen Christina S. Werner Szilvia Geyh 《Quality of life research》2014,23(10):2693-2705