全文获取类型
收费全文 | 35231篇 |
免费 | 2751篇 |
国内免费 | 427篇 |
专业分类
耳鼻咽喉 | 363篇 |
儿科学 | 1031篇 |
妇产科学 | 631篇 |
基础医学 | 5131篇 |
口腔科学 | 528篇 |
临床医学 | 3303篇 |
内科学 | 7550篇 |
皮肤病学 | 783篇 |
神经病学 | 2684篇 |
特种医学 | 1306篇 |
外国民族医学 | 16篇 |
外科学 | 4256篇 |
综合类 | 1284篇 |
现状与发展 | 1篇 |
一般理论 | 4篇 |
预防医学 | 2760篇 |
眼科学 | 693篇 |
药学 | 2680篇 |
6篇 | |
中国医学 | 623篇 |
肿瘤学 | 2776篇 |
出版年
2023年 | 281篇 |
2022年 | 681篇 |
2021年 | 1140篇 |
2020年 | 692篇 |
2019年 | 886篇 |
2018年 | 1070篇 |
2017年 | 769篇 |
2016年 | 777篇 |
2015年 | 953篇 |
2014年 | 1225篇 |
2013年 | 1564篇 |
2012年 | 2298篇 |
2011年 | 2290篇 |
2010年 | 1397篇 |
2009年 | 1153篇 |
2008年 | 1688篇 |
2007年 | 1713篇 |
2006年 | 1627篇 |
2005年 | 1552篇 |
2004年 | 1369篇 |
2003年 | 1304篇 |
2002年 | 1232篇 |
2001年 | 1116篇 |
2000年 | 1101篇 |
1999年 | 979篇 |
1998年 | 351篇 |
1997年 | 301篇 |
1996年 | 264篇 |
1995年 | 212篇 |
1994年 | 208篇 |
1993年 | 175篇 |
1992年 | 517篇 |
1991年 | 501篇 |
1990年 | 474篇 |
1989年 | 432篇 |
1988年 | 453篇 |
1987年 | 381篇 |
1986年 | 372篇 |
1985年 | 365篇 |
1984年 | 256篇 |
1983年 | 187篇 |
1982年 | 119篇 |
1981年 | 104篇 |
1979年 | 210篇 |
1978年 | 111篇 |
1977年 | 124篇 |
1976年 | 113篇 |
1974年 | 130篇 |
1972年 | 128篇 |
1969年 | 104篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
12.
13.
B Kerboul J Le Saout C Lefevre D Miroux L Fabre J F Le Noac'h J M Rogero B Courtois 《Journal de chirurgie》1986,123(6-7):428-434
Results of three therapeutic modalities used for the treatment of a homogeneous series of patients with a Pouteau Colles fracture are analyzed. Orthopedic treatment provided deceiving results. Pinning was, on the contrary, very effective, intrafocal pinning with immediate mobilization of the wrist appearing perfectly effective. Few complications were reported in contrast to plastered immobilizations. Good results were obtained in 80% of cases and functional recovery was rapid, indicating that this method represents undoubted progress when compared with conventional therapies. 相似文献
14.
Effect of acute tyrosine depletion in using a branched chain amino-acid mixture on dopamine neurotransmission in the rat brain. 总被引:1,自引:0,他引:1
Marisa Le Masurier Weite Oldenzeil Claire Lehman Philip Cowen Trevor Sharp 《Neuropsychopharmacology》2006,31(2):310-317
Central dopamine function is reduced by decreasing the availability of the catecholamine precursor, tyrosine, using a tyrosine-free amino acid mixture containing multiple large neutral as well as branched chain amino-acids, which compete with tyrosine for uptake into the brain. Current mixtures are cumbersome to make and administer, and unpalatable to patients and volunteers. Here, we investigate whether individual or limited amino-acid combinations could reduce brain tyrosine levels and hence dopamine function. Measurements of regional brain tyrosine levels, catecholamine and indoleamine synthesis (L-DOPA and 5-HTP accumulation, respectively) were used to identify an effective paradigm to test in neurochemical, behavioral and fos immunocytochemical models. Administration of leucine or isoleucine, or a mixture of leucine, isoleucine, and valine reduced tyrosine and 5-HTP, but not L-DOPA accumulation. A mixture of leucine, valine, and isoleucine supplemented with tryptophan reduced brain tyrosine and L-DOPA, but not 5-HTP. In microdialysis experiments this amino-acid mixture reduced basal and amphetamine-evoked striatal dopamine release, as well as amphetamine-induced hyperactivity. This mixture also reduced amphetamine-induced fos expression in striatal areas. In conclusion, the present study identified a small combination of amino acids that reduces brain tyrosine and dopamine function in a manner similar to mixtures of multiple amino acids. This minimal mixture may have use as a dopamine reducing paradigm in patient and volunteer studies. 相似文献
15.
16.
17.
ATP synthesis from PCr through creatine kinase reaction was measured in vivo in rat leg muscle using 31P NMR magnetization transfer and progressive saturation. Both techniques determined a spin-lattice relaxation time for PCr of 3 s at rest and an identical forward rate constant of 0.22-0.26 s-1. In stimulated muscles, magnetization transfer showed that flux was not changed with a steady-state PCr of 54% of initial level. During stimulation inducing a PCr decrease to 38% of initial value, flux was significantly lowered by 30%. These findings could result from an accumulation of ions and water increases or from compartmentation of ATP and PCr in different pools either in the muscle cell or in the different muscle fibers. In addition, these results could reinforce the hypothesis against a crucial role for creatine kinase shuttle in the ATP supply in skeletal muscle. 相似文献
18.
19.
20.
Exclusive elemental enteral diet in cortico-resistant and cortico-dependent forms of Crohn's disease
Y Le Quintrec J Cosnes M Le Quintrec J F Contou P Baumer J Bellanger J P Gendre 《Gastroentérologie clinique et biologique》1987,11(6-7):477-482
The aim of this study was to investigate the value of elemental diet in steroid-resistant and steroid-dependent Crohn's disease. Elemental diet (Vivonex HN, 39.4 +/- 9.2 kcal/kg/d) was delivered through a nasogastric tube at a constant rate. Twenty therapeutic periods lasting from 20 to 74 days (median, 32 days) were undertaken in 18 patients. Elemental diet was well tolerated. Mean values of hemoglobin, serum albumin, and serum transferrin increased significantly through the therapeutic period; body weight and anthropometric data did not change significantly. The short-term response to elemental diet was excellent in 11 cases, demonstrated by achievement of clinical remission and steroid withdrawal; six patients had an incomplete remission and remained slightly active or had to be maintained under low dose steroids; three patients did not respond to therapy and had to be operated upon. During the follow-up (6-30 months), 8 patients out of 17 had a relapse. Relapse was controlled by medical therapy in 5 cases and led to surgery in the 3 other cases. We conclude that elemental diet, as total parenteral nutrition, is an effective therapy of steroid-resistant and steroid-dependent Crohn's disease. However, elemental diet does not prevent relapse. 相似文献