全文获取类型
收费全文 | 10892篇 |
免费 | 735篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 128篇 |
儿科学 | 455篇 |
妇产科学 | 215篇 |
基础医学 | 1772篇 |
口腔科学 | 337篇 |
临床医学 | 741篇 |
内科学 | 2338篇 |
皮肤病学 | 296篇 |
神经病学 | 1322篇 |
特种医学 | 331篇 |
外科学 | 1352篇 |
综合类 | 45篇 |
一般理论 | 3篇 |
预防医学 | 828篇 |
眼科学 | 155篇 |
药学 | 667篇 |
中国医学 | 22篇 |
肿瘤学 | 652篇 |
出版年
2023年 | 71篇 |
2022年 | 120篇 |
2021年 | 260篇 |
2020年 | 167篇 |
2019年 | 308篇 |
2018年 | 313篇 |
2017年 | 210篇 |
2016年 | 223篇 |
2015年 | 277篇 |
2014年 | 356篇 |
2013年 | 397篇 |
2012年 | 691篇 |
2011年 | 743篇 |
2010年 | 427篇 |
2009年 | 437篇 |
2008年 | 682篇 |
2007年 | 673篇 |
2006年 | 671篇 |
2005年 | 643篇 |
2004年 | 656篇 |
2003年 | 626篇 |
2002年 | 529篇 |
2001年 | 286篇 |
2000年 | 305篇 |
1999年 | 276篇 |
1998年 | 107篇 |
1997年 | 87篇 |
1996年 | 84篇 |
1995年 | 57篇 |
1994年 | 53篇 |
1993年 | 52篇 |
1992年 | 132篇 |
1991年 | 95篇 |
1990年 | 85篇 |
1989年 | 64篇 |
1988年 | 47篇 |
1987年 | 44篇 |
1986年 | 47篇 |
1985年 | 44篇 |
1984年 | 37篇 |
1983年 | 23篇 |
1982年 | 18篇 |
1979年 | 24篇 |
1978年 | 21篇 |
1976年 | 24篇 |
1975年 | 22篇 |
1974年 | 14篇 |
1973年 | 19篇 |
1972年 | 13篇 |
1967年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
The effects of bilateral electrolytic lesions of hypothalamic paraventricular nucleus on thyrotropin-releasing hormone (TRH)-immunoreactive fibers of the nucleus of the solitary tract were studied by both immunocytochemistry and radioimmunoassay. Contrasting with a near disappearance of TRH immunoreactivity in the median eminence, both morphological and biochemical approaches demonstrate that such hypothalamic lesions induced significant increase of TRH immunoreactivity in the nucleus of solitary tract. These results confirm that TRH fibers of the nucleus of the solitary tract do not originate in the hypothalamic paraventricular nucleus (PVN). They further indicate that these TRH neurons projecting to the nucleus of the solitary tract are strongly influenced by neurons located within the PVN area. 相似文献
22.
The interlocking intramedullary nail has greatly expanded the indications for closed intramedullary nailing of the femur. We describe a complication caused by the presence of a calcified lesion located at the proximal metaphyseal-diaphyseal junction of the femur. This lesion could not be penetrated by hand reamers. We used a long 3.5-mm drill bit to place a hole in the infarct, which then allowed passage of the hand reamer. The operation then proceeded in the standard fashion without complications. 相似文献
23.
S de Sanjosé M Santamaria P Alonso de Ruiz N Aristizabal E Guerrero X Castellsagué F X Bosch 《IARC scientific publications》1992,(119):75-84
PCR-based hybridization methods have been used to show that some women with normal cytology are carriers of HPV DNA of the types strongly related to cervical cancer. How these women should be managed remains unclear. This chapter selectively reviews reports which have estimated type-specific HPV prevalence in relation to the presence or absence of morphological signs of HPV infection. Overall, these reports indicate that among women who were identified as carriers of HPV DNA (by PCR-based methods) and who also had a normal cytological smear, the HPV type detected in the majority of instances was a high-risk viral type for cervical cancer (HPV types 16/18 = 44.7%; HPV types 31/33/35 = 8.1%; other and unknown types = 37.9%). This suggests that screening programmes which include PCR-based HPV detection could reduce the false negative rates currently reported by screening programmes based on cytology alone. 相似文献
24.
Manic episode with psychotic symptoms induced by subthalamic nucleus stimulation in a patient with Parkinson's disease. 总被引:5,自引:0,他引:5
Jan Herzog Julia Reiff Paul Krack Karsten Witt Bettina Schrader Dieter Müller Günther Deuschl 《Movement disorders》2003,18(11):1382-1384
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy for Parkinson's disease (PD). A manic episode with psychotic symptoms induced by STN-DBS occurred in a previously psychiatrically healthy patient, focusing on the role of STN-DBS in influencing not only motor but also emotional behaviour. 相似文献
25.
Pancreatitis and hyperparathyroidism 总被引:2,自引:0,他引:2
A Sitges-Serra M Alonso C de Lecea P F Gores D E Sutherland 《The British journal of surgery》1988,75(2):158-160
Hypercalcaemia is considered to be a rare cause of pancreatitis but the true cause-and-effect relationship between hyperparathyroidism and pancreatic inflammatory disease remains controversial. Over 100 patients have been reported in whom both processes have occurred concurrently, but doubts have been expressed as to whether or not this association is due to chance. We report 10 new cases of hypercalcaemic hyperparathyroidism associated with different types of pancreatitis. Seven patients had primary hyperparathyroidism and three had hyperparathyroidism after renal transplantation. Two experienced acute pancreatitis after parathyroidectomy. Of the remaining eight patients, five had hypercalcaemia equal to or above 120 mg/l. The prevalence of pancreatitis in our series of 86 cases of primary hyperparathyroidism is 8 per cent. Acute and chronic calcifying types of pancreatitis were observed. Three patients died of the disease, two of them after renal transplantation. It is suggested that pancreatitis may complicate the clinical course of hyperparathyroidism, particularly when hypercalcaemia is moderate to severe and/or there are other risk factors such as treatment with steroids and azathioprine after renal transplantation. 相似文献
26.
27.
Different proliferative activity of the glandular and myoepithelial lineages in benign proliferative and early malignant breast diseases. 总被引:3,自引:0,他引:3
Agnes Bánkfalvi Andreas Ludwig Bettina De-Hesselle Horst Buerger Igor B Buchwalow Werner Boecker 《Modern pathology》2004,17(9):1051-1061
The aim of the present study was to explore cell biological characteristics of normal breast, benign proliferative breast diseases and noninvasive breast malignancies based on the recently published adult progenitor cell concept from our group. Here, we investigated the proliferative activity of CK5/14(+), CK8/18/19(+) and alpha-smooth muscle actin(+) cellular phenotypes encountered in normal mammary gland, in a series of usual ductal hyperplasias and early malignant breast diseases, such as atypical ductal and lobular hyperplasias, as well as ductal and lobular in situ carcinomas. Immunohistochemical double labeling was performed on frozen sections from diagnostic breast biopsies by using antibodies to basal cytokeratins (CK5/14), glandular cytokeratins (CK8/18/19), smooth muscle actin and the Ki-67 antigen (MIB1). Normal breast tissues and usual ductal hyperplasias were characterized by a heterogeneous cellular composition of the growth fraction. The proliferative cell compartment consisted of CK8/18/19(+) glandular and, in a variable proportion, CK5/14(+) progenitor phenotypes. In contrast, noninvasive breast malignancies were composed of a monotonous proliferation of CK 8/18/19(+) neoplastic glandular cells. These findings indicate a significant role of progenitor cells in the development of benign proliferative breast diseases and lend support to the view that malignant transformation in the human breast usually occurs in a cell committed to the glandular lineage. Our results provide cell kinetic support to the functional progenitor cell hypothesis, and we propose this concept as an operative model for understanding benign proliferative and malignant breast diseases. 相似文献
28.
M de la Hera A de la Hera A Ramos L Buelta J L Alonso V Rodriguez-Valverde J Merino 《International immunology》1992,4(1):67-74
BALB/c mice injected at birth with 10(8) semi-allogeneic (C57BL/6 x BALB.IgHb)F1 spleen cells develop a lupus-like syndrome in which autoantibodies bear exclusively the donor allotype. We have analyzed the evolution of donor B cell chimerism and the autoimmune manifestations during the first year of life in these mice. Anti-DNA, -histone, and -cardiolipin IgG antibodies as well as circulating immune complexes appeared in the second week of life, reached the highest values around the sixth week, and then progressively dropped to normal values after the sixth month in most mice. The kinetics of the evolution of the autoimmune manifestations, as well as the kinetics of serum donor Ig allotype, were parallel to the kinetics of donor B cell chimerism, which was particularly prominent in the spleens in early weeks of life, and progressively decreased after remission of the autoimmune syndrome. Membrane-proliferative glomerulonephritis, which was followed as the more representative histological abnormality in this model, was particularly evident after 10 weeks of life, but disappeared by the end of the follow-up. Interestingly, when mice with a self-limited disease were re-injected with 10(8) F1 spleen cells i.v., a flare in the serological manifestations was observed. In these re-injected mice a predominance of anti-DNA, IgG1 antibodies bearing exclusively the donor allotype was also observed, as in the early weeks of life.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
29.
30.
Arend Bökenkamp Bettina Bohnhorst Christian Beier Norbert Albers Gisela Offner Johannes Brodehl 《Pediatric nephrology (Berlin, Germany)》1994,8(2):181-185
Gingival hyperplasia is a common side-effect of immunosuppression with cyclosporine A. Nifedipine is often used to control hypertension in kidney graft recipients. Analysis of gingival status in 106 children transplanted at our centre, and treated either with azathioprine, cyclosporine A or both, revealed significantly higher degrees of gingival overgrowth in those children receiving a combination of cyclosporine A and nifedipine compared with those children treated with cyclosporine A or nifedipine alone. Seven children undergoing gingivectomy at our centre over the past few years had received this combination. After a change in the antihypertensive regimen, avoiding long-term nifedipine medication, and improved dental care with chlorhexidine gel, we noted a reduction in the degree of gingival hyperplasia. In the majority of patients, nifedipine could be replaced by a single drug, usually hydralazine. We therefore recommend avoiding calcium channel blockers in the long-term management of hypertension in patients receiving cyclosporine. 相似文献