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61.
Alessandra Mazzo José Carlos Amado Martins Beatriz Maria Jorge Rui Carlos Negr?o Batista Rodrigo Guimar?es dos Santos Almeida Fernando Manuel Dias Henriques Verónica Rita Dias Coutinho Isabel Amélia Costa Mendes 《Revista latino-americana de enfermagem》2015,23(5):814-820
Objective:
to validate an instrument to measure self-confidence of nursing care in urinary retention.Methods:
methodological research study, carried out after ethical approval. A Likert-like scale of 32 items related to nursing care in urinary retention was applied to students of the graduate nursing course. For instrument validation, analysis of the sample adequacy and main components, Varimax orthogonal rotation and internal consistency analyses were developed.Results:
in a sample of 305 students, there was high correlation of all items with the total scale and Cronbach''s alpha of 0.949. The scale items were divided into five factors with internal consistency: Factor 1 (0.890), Factor 2 (0.874), Factor 3 (0.868), Factor 4 (0.814) and Factor 5 (0.773), respectively.Conclusion:
the scale meets the validity requirements, demonstrating potential for use in evaluation and research. 相似文献62.
Juan Carlos Silva Marco Antonio Diaz Eugenio Maul Beatriz E. Munoz 《Ophthalmic epidemiology》2015,22(3):231-236
AbstractPurpose: A prevalence survey for active trachoma in children aged under 10 years and trichiasis in women aged 40 years and older was carried out in four districts in the Sololá region in Guatemala, which is suspected of still having a trachoma problem.Methods: Population-based surveys were undertaken in three districts, within 15 randomly selected communities in each district. In addition, in a fourth district that borders the third district chosen, we surveyed the small northern sub-district, by randomly selecting three communities in each community, 100 children aged under 10 years were randomly selected, and all females over 40 years. Five survey teams were trained and standardized. Trachoma was graded using the World Health Organization simplified grading scheme and ocular swabs were taken in cases of clinical follicular or inflammatory trachoma. Prevalence estimates were calculated at district and sub-district level.Results: Trachoma rates at district level varied from 0–5.1%. There were only two sub-districts where active trachoma approached 10% (Nahualá Costa, 8.1%, and Santa Catarina Costa, 7.3%). Trichiasis rates in females aged 40 years and older varied from 0–3%. Trachoma was likely a problem in the past.Conclusions: Trachoma is disappearing in the Sololá region in Guatemala. Health leadership may consider further mapping of villages around the areas with an especially high rate of trachoma and infection, and instituting trichiasis surgery and active trachoma intervention where needed. 相似文献
63.
64.
Hernández-Díaz Yazmín González-Castro Thelma Beatriz Tovilla-Zárate Carlos Alfonso López-Narváez María Lilia Genis-Mendoza Alma Delia Castillo-Avila Rosa Giannina Ramos-Méndez Miguel Ángel Juárez-Rojop Isela Esther 《Metabolic brain disease》2021,36(8):2415-2424
Metabolic Brain Disease - Schizophrenia is a debilitating mental illness. Levels of oxytocin have been proposed as a biomarker of schizophrenia; however, the observed levels of oxytocin in... 相似文献
65.
Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells 总被引:1,自引:0,他引:1
Beatriz Bellosillo Dolors Colomer Gabriel Pons & Joan Gil 《British journal of haematology》1998,100(1):142-146
B-chronic lymphocytic leukaemia (B-CLL) is characterized by the accumulation of long-lived CD5+ B lymphocytes. The effect of mitoxantrone, a topoisomerase II inhibitor, on B-CLL cells was studied. Treatment of B-CLL cells for 48 h with mitoxantrone (0.5 μg/ml) induced a decrease in cell viability as determined by MTT assay. The IC50 calculated for the cells of three patients was 0.7 μg/ml for two of them and 1.4 μg/ml for the third. In all three patients the maximum effect was observed with 2 μg/ml. An additive cytotoxic effect was observed when mitoxantrone (0.5 μg/ml) was combined with fludarabine (5 μg/ml). Mitoxantrone induced DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), a marker of the activation of caspases, in all the patients studied, demonstrating that the cytotoxic effect of mitoxantrone was due to induction of apoptosis. These results suggest that mitoxantrone, and possibly other topoisomerase II inhibitors, may be used in the chemotherapy of B-CLL, and that combination of mitoxantrone with fludarabine or other drugs could improve the effectiveness of the treatment. 相似文献
66.
Rivas P Górgolas M Gimena B Sousa J Fernández-Guerrero ML 《Scandinavian journal of infectious diseases》2005,37(5):373-374
We present a 68-y-old female who had undergone aortocoronary bypass and developed Staphylococcus aureus sternal osteomyelitis. Despite prolonged therapy with different antibiotics and several local debridements and drainage, the wound remained open and suppurative. Only after sternectomy and wide excision of infected costal cartilage was the diagnosis of sternal tuberculosis made, 24 months later. This case illustrates the necessity of a high degree of suspicion to diagnose this very rare entity which coexists with more common causes of sternal osteomyelitis. 相似文献
67.
Yujuan Wang Beatriz E. Marciano Defen Shen Rachel J. Bishop Stanley Park Steven M. Holland Chi-Chao Chan 《Journal of clinical immunology》2013,33(5):917-924
Purpose
Chronic granulomatous disease (CGD) is an inherited disorder characterized by defects in phagocyte-derived nicotinamide adenine dinucleotide phosphate oxidase. It is typically diagnosed in childhood and leads to severe, recurrent bacterial or fungal infections. Chorioretinal lesions are the most common ocular manifestation. We sought to determine whether there are infectious agents in CGD-associated chorioretinopathy.Methods
Medical records and ocular histopathology from CGD cases from January 1983 to January 2012 at the National Institutes of Health were retrospectively reviewed. Chorioretinal cells from normal and lesional tissues of the same eye were microdissected. Primers for Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia sp., and a panbacterial 16S ribosomal DNA were used for polymerase chain reaction.Results
Seventeen CGD patients had ocular tissues (16 autopsied cases and 1 chorioretinal biopsy) examined. Of these 17, 8 demonstrated CGD-associated chorioretinal lesions in at least one eye on histopathology. Of these 8, 7 showed amplification of 16S ribosomal DNA within the lesion; of these 7, two also amplified S. epidermidis and one P. aeruginosa. One had no bacterial DNA amplified. Importantly, no microbial DNA was amplified from the normal, non-lesional ocular tissues of these 8 cases. Furthermore, only 1 of the 9 eyes without chorioretinopathy had amplified Burkholderia DNA, that patient had a history of Burkholderia infection.Conclusions
We detected bacterial DNA in 7 of 8 (88 %) cases with CGD-associated chorioretinopathy and only in 1 normal ocular tissue of 17 CGD cases. Bacterial infection may play a role in the pathogenesis of CGD-associated chorioretinal lesions. 相似文献68.
Navas-Sánchez Francisco J. Fernández-Pena Alberto Martín de Blas Daniel Alemán-Gómez Yasser Marcos-Vidal Luís Guzmán-de-Villoria Juan A. Fernández-García Pilar Romero Julia Catalina Irene Lillo Laura Muñoz-Blanco José L. Ordoñez-Ugalde Andrés Quintáns Beatriz Pardo Julio Sobrido María-Jesús Carmona Susanna Grandas Francisco Desco Manuel 《Journal of neurology》2021,268(7):2429-2440
Journal of Neurology - SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP) caused by mutations in the SPAST gene. HSP is considered an upper motor neuron disorder... 相似文献
69.
Ane Murueta‐Goyena Rocío Del Pino Marta Galds Begoa Arana Marian Acera Mar Carmona‐Abelln Tamara Fernndez‐Valle Beatriz Tijero Olaia Lucas‐Jimnez Natalia Ojeda Naroa Ibarretxe‐Bilbao Javier Pea Jesus Cortes Unai Ayala Maitane Barrenechea Juan Carlos Gmez‐Esteban Iigo Gabilondo 《Annals of neurology》2021,89(1):165-176
70.
Luis Velázquez-Pérez DSc Roberto Rodriguez-Labrada PhD Yasmani González-Garcés BSc Eduardo Arrufat-Pie MD Reidenis Torres-Vega BSc Jacqueline Medrano-Montero PhD Beatriz Ramirez-Bautista MD Yaimeé Vazquez-Mojena MSc Georg Auburger MD Fay Horak PhD Ulf Ziemann PhD Christopher M. Gomez PhD 《Movement disorders》2021,36(2):471-480