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Background
The aims of the study are to evaluate attitudes about childhood vaccines and vaccine refusal or delay among parents and to assess the role played by the variables mapped as potential determinants to suggest strategies that could improve childhood vaccination rates.Methods
The cross-sectional study was intended for parents of kindergarteners. Parental attitudes were measured using the Parent Attitudes about Childhood Vaccines (PACV) survey, to screen for Vaccine Hesitancy (VH). In addition, selected factors have been grouped in three categories (contextual, individual and group and vaccine/vaccination-specific influences), and were explored as potential determinant of VH and vaccination refusal or delay.Results
7.7% of subjects were defined as VH parents (VHPs) through PACV score, while 24.6% reported having refused or delayed at least one dose of vaccine for their child. VH was more common in those parents that decided not to vaccinate their child after having received information from mass-media, in those who did not agree with mandatory vaccinations, and in those who agreed with political leaders who oppose to vaccination. Vaccine refusing/delaying parents were more frequently those who agreed that infant vaccinations are primarily an economic business of pharmaceutical companies, and who disagreed that access to the kindergarten should only be allowed to children who had been vaccinated.Conclusion
The findings of the present study emphasize the importance of PACV as a tool to screen VHPs. Furthermore, results highlight important potential determinants of VH, such as communication and media environment, and attitudes about prevention. Health care providers could act as key components to improve the public trust to scientific and epidemiological evidence. 相似文献73.
S.A.V. van Asten M. Boattini M.E.M. Kraakman G. Bianco M. Iannaccone C. Costa R. Cavallo A.T. Bernards 《Journal of infection and chemotherapy》2021,27(5):778-780
ObjectivesSince the introduction of the β-lactam/β-lactamase inhibitor ceftazidime-avibactam (CZA), rapid evolution of resistance has been reported in different KPC-producing Klebsiella pneumoniae isolates. In this multicenter retrospective study, we describe the emergence of CZA resistance and evaluate the mutations that might be responsible for the restoration of carbapenem susceptibility.MethodsDuring a study period of 18 months, KPC-producing K. pneumoniae isolates of five hospitalized patients were collected with phenotypic development of CZA resistance.ResultsIn vitro restoration of carbapenem susceptibility during treatment was observed in 3 isolates. Whole genome sequencing of these isolates showed a D179Y mutation in the KPC gene of 2 variants and a KPC-2 with a Δ242-GT-243 deletion (KPC-14). Two KPC-3 variants showed CZA resistance with sustained carbapenemase activity without genomic adaptations in the KPC gene.ConclusionsThis study confirms the emergence of CZA resistance in KPC K. pneumoniae. The role of carbapenems in treating patients with these variants is unclear and combination therapies warrant further investigation. 相似文献
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Factors Associated with Reported Infection and Lymphedema Symptoms among Individuals with Extremity Lymphedema
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Jie Deng PhD RN OCN Mei R. Fu PhD RN APRN‐BC FAAN Jane M. Armer PhD RN FAAN Janice N. Cormier MD MPH M. Elise Radina PhD CFLE Saskia R.J. Thiadens RN Jan Weiss PT DHS CLT‐LANA Catherine M. Tuppo PT MS CLT‐LANA Mary S. Dietrich PhD Sheila H. Ridner PhD RN FAAN 《Rehabilitation nursing》2015,40(5):310-319
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A diaper bank and home visiting partnership: Initial exploration of research and policy questions
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