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排序方式: 共有970条查询结果,搜索用时 562 毫秒
31.
Lucile Mercadal Mathieu Coudert Anne Vassault Laurence Pieroni Alain Debure Messaoud Ouziala Hélène Depreneuf Christine Fumeron Aude Servais Nader Bassilios Jacques Bécart Ubald Assogba Mahmoud Allouache Boussad Bouali Nhan Luong Marie Paul Dousseaux Sophie Tezenas-du Montcel Gilbert Deray 《Clinical journal of the American Society of Nephrology》2012,7(11):1836-1842
32.
Aerts-Toegaert C Heirman C Tuyaerts S Corthals J Aerts JL Bonehill A Thielemans K Breckpot K 《European journal of immunology》2007,37(3):686-695
Human CD83 is a marker molecule for mature dendritic cells (DC) and is also expressed on activated B and T cells. Although CD83 has been implicated in immune responses, its function on DC and T cells remains unclear. In this study, we wanted to assess the role of CD83 expressed on DC and T cells in the immune response. Down-regulation of CD83 expression on human DC through RNA interference (RNAi) results in a less potent induction of allogeneic T cell proliferation, reduced IFN-gamma secretion by established T cells and decreased capacity in the priming of functional tumor antigen-specific CD8+ T lymphocytes. In addition, CD83 mRNA-electroporated DC are stronger T cell stimulators. However, CD83 overexpression on Melan-A/MART-1-specific tumor-infiltrating lymphocytes (TIL) circumvents the need for CD83 expression on DC. Co-culture of immature DC with TIL or K562 cells overexpressing CD83 results in the production of enhanced levels of pro-inflammatory cytokines, whereas this production is less pronounced or even absent in co-cultures with non-modified TIL or K562 cells. In conclusion, we demonstrate that CD83 expression on T cells and DC modulates the immune response by activating DC and by delivering costimulatory signals for the stimulation of naive and memory T cells, respectively. 相似文献
33.
Prevalence of occupational exposure to asbestos and crystalline silica according to phenotypes of lung cancer from the CaProMat study: A case‐only study
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Mohamad El Zoghbi PhD Pascale Salameh PharmD PhD Isabelle Stücker PhD Christophe Paris MD PhD Jean C. Pairon MD PhD Antoine Gislard MD Jack Siemiatycki PhD Vincent Bonneterre MD PhD Bénédicte Clin MD PhD Patrick Brochard MD PhD Fleur Delva MD PhD Aude Lacourt PhD 《American journal of industrial medicine》2018,61(1):85-99
Background
The objective of the study was to compare the prevalence of occupational exposure to asbestos and crystalline silica according to histological types of lung cancer and age at diagnosis.Methods
CaProMat study is a pooled case‐only study conducted between 1996 and 2011. The current study consisted of 6521 lung cancer cases. Occupational exposure to asbestos and crystalline silica was assessed by two Job‐Exposure Matrices. A weighted prevalence of exposure was derived and compared according to histological types and age at diagnosis.Results
There was no difference of weighted prevalence of exposure to asbestos and crystalline silica according to histological types of lung cancer. There was a statistically significant difference of weighted prevalence of exposure to asbestos and crystalline silica according to age at diagnosis.Conclusions
Due to the limited clinical importance of the difference, neither the histological type, nor the age at diagnosis can be used as an indicator for the occupational exposure to asbestos or crystalline silica.34.
Beard Rachel E. Khan Sidrah Troisi Roberto I. Montalti Roberto Vanlander Aude Fong Yuman Kingham T. Peter Boerner Thomas Berber Eren Kahramangil Bora Buell Joseph F. Martinie John B. Vrochides Dionisios Shen Chengli Molinari Michele Geller David A. Tsung Allan 《World journal of surgery》2020,44(3):887-895
World Journal of Surgery - To assess long-term oncologic outcomes of robotic-assisted liver resection (RLR) for colorectal cancer (CRC) metastases as compared to a propensity-matched cohort of... 相似文献
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37.
Emma G. Wilmot PhD Kelly L. Close MBA Dubravka Jurišić-Eržen MD Daniela Bruttomesso MD F. Javier Ampudia-Blasco MD Zsolt Bosnyak MD Aude Roborel de Climens PhD Grégory Bigot MSc Anne L. Peters MD Eric Renard MD Lori Berard RN Luis Eduardo Calliari MD Jochen Seufert MD 《Diabetes, obesity & metabolism》2021,23(8):1892-1901
38.
The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase 总被引:3,自引:0,他引:3
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40.
Fermé C Sebban C Hennequin C Diviné M Lederlin P Gabarre J Ferrant A Caillot D Bordessoule D Brice P Moullet I Berger F Lepage E 《Blood》2000,95(7):2246-2252
The treatment of advanced Hodgkin's disease (HD) with chemotherapy (CTx) alone or combined modality treatments has been controversial. In 1989, we designed a randomized study to compare 2 cycles of CTx to (sub)total nodal irradiation (RTx) as consolidation treatments for patients with stage IIIB/IV HD in complete remission (CR) or good partial response after 6 cycles of CTx. A total of 559 patients were randomized to receive 6 cycles of MOPP/ABV (mechlorethamine, vincristine, procarbazine, prednisone/Adriamycin [doxorubicin], bleomycin, vinblastine) hybrid (n = 266) or ABVPP (n = 267). After induction treatment, 418 patients could be evaluated for the consolidation phase. With a median follow-up of 48 months, the 5-year disease-free survival estimates were 80% for 8 cycles of MOPP/ABV, 82% for 6 cycles of MOPP/ABV plus RTx, 68% for 8 cycles of ABVPP, and 75% for 6 cycles of ABVPP plus RTx (P =.01). The 5-year disease-free survival estimates did not differ between CTx and RTx, 74% and 79%, respectively (P =.07). After MOPP/ABV, the 5-year overall survival estimates did not differ between CTx and RTx, 85% and 88%, respectively (P =.2). After ABVPP, the 5-year survival estimates were 94% for CTx and 78% for RTx (P =.002). These results showed that RTx was not superior to CTx consolidation after doxorubicin-induced CR for patients with advanced HD. Because of the uncertainty of obtaining a prolonged second remission for patients relapsing after CTx and RTx and the possible long-term effects of RTx, we prefer 8 cycles of CTx as standard treatment when a CR has been achieved after 6 cycles. 相似文献