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101.
The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase 总被引:3,自引:0,他引:3
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Chapuis AG Casper C Kuntz S Zhu J Tjernlund A Diem K Turtle CJ Cigal ML Velez R Riddell S Corey L Greenberg PD 《Blood》2011,117(20):5391-5402
Most HIV+ individuals require lifelong highly active antiretroviral therapy (HAART) to suppress HIV replication, but fail to eliminate the virus in part because of residual replication in gut-associated lymphoid tissues (GALT). Naturally elicited HIV-specific CD8+ T cells generated in the acute and chronic infectious phases exhibit antiviral activity, but decrease in number after HAART. Therapeutic vaccines represent a potential strategy to expand cellular responses, although previous efforts have been largely unsuccessful, conceivably because of a lack of responding HIV-specific central-memory CD8+ T cells (Tcm). To determine whether patients receiving HAART possess CD8+ T cells with Tcm qualities that are amenable to augmentation, HIV-specific CD8+ T-cell clones were derived from HIV-reactive CD28+CD8+ T-cell lines isolated from 7 HIV+ HAART-treated patients, expanded ex vivo, and reinfused into their autologous host. Tracking of the cells in vivo revealed that clones could persist for ≥ 84 days, maintain expression and/or re-express CD28, up-regulate CD62L, secrete IL-2, proliferate on cognate Ag encounter and localize to the rectal mucosa. These results suggest some infused cells exhibited phenotypic and functional characteristics shared with Tcm in vivo, and imply that more effective therapeutic vaccination strategies targeting CD8+ Tcm in patients on HAART might provide hosts with expanded, long-lasting immune responses not only systemically but also in GALT. 相似文献
104.
Antonia Di Micco Gianluca Frera Jér?me Lugrin Yvan Jamilloux Erh-Ting Hsu Aubry Tardivel Aude De Gassart Léa Zaffalon Bojan Bujisic Stefanie Siegert Manfredo Quadroni Petr Broz Thomas Henry Christine A. Hrycyna Fabio Martinon 《Proceedings of the National Academy of Sciences of the United States of America》2016,113(32):E4671-E4680
105.
Incidence, Clinical Features, and Outcome of All Trans-Retinoic Acid Syndrome in 413Cases of Newly Diagnosed Acute Promyelocytic Leukemia 总被引:13,自引:0,他引:13
De Botton S.; Dombret H.; Sanz M.; Miguel J. San; Caillot D.; Zittoun R.; Gardembas M.; Stamatoulas A.; Conde E.; Guerci A.; Gardin C.; Geiser K.; Makhoul D. Cony; Reman O.; de la Serna J.; Lefrere F.; Chomienne C.; Chastang C.; Degos L.; Fenaux P.; Group the European APL 《Blood》1998,92(8):2712-2718
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Nicol X Voyatzis S Muzerelle A Narboux-Nême N Südhof TC Miles R Gaspar P 《Nature neuroscience》2007,10(3):340-347
Spontaneous activity generated in the retina is necessary to establish a precise retinotopic map, but the underlying mechanisms are poorly understood. We demonstrate here that neural activity controls ephrin-A-mediated responses. In the mouse retinotectal system, we show that spontaneous activity of the retinal ganglion cells (RGCs) is needed, independently of synaptic transmission, for the ordering of the retinotopic map and the elimination of exuberant retinal axons. Activity blockade suppressed the repellent action of ephrin-A on RGC growth cones by cyclic AMP (cAMP)-dependent pathways. Unexpectedly, the ephrin-A5-induced retraction required cAMP oscillations rather than sustained increases in intracellular cAMP concentrations. Periodic photo-induced release of caged cAMP in growth cones rescued the response to ephrin-A5 when activity was blocked. These results provide a direct molecular link between spontaneous neural activity and axon guidance mechanisms during the refinement of neural maps. 相似文献
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Comparison of 60 or 90 mg/m2 of daunorubicin in induction therapy for acute myeloid leukemia with intermediate or unfavorable cytogenetics 下载免费PDF全文