全文获取类型
收费全文 | 5154篇 |
免费 | 252篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 309篇 |
妇产科学 | 58篇 |
基础医学 | 480篇 |
口腔科学 | 261篇 |
临床医学 | 392篇 |
内科学 | 975篇 |
皮肤病学 | 165篇 |
神经病学 | 393篇 |
特种医学 | 207篇 |
外科学 | 807篇 |
综合类 | 90篇 |
一般理论 | 2篇 |
预防医学 | 229篇 |
眼科学 | 220篇 |
药学 | 363篇 |
中国医学 | 26篇 |
肿瘤学 | 406篇 |
出版年
2024年 | 5篇 |
2023年 | 38篇 |
2022年 | 74篇 |
2021年 | 181篇 |
2020年 | 90篇 |
2019年 | 137篇 |
2018年 | 152篇 |
2017年 | 137篇 |
2016年 | 151篇 |
2015年 | 182篇 |
2014年 | 267篇 |
2013年 | 315篇 |
2012年 | 485篇 |
2011年 | 525篇 |
2010年 | 273篇 |
2009年 | 225篇 |
2008年 | 319篇 |
2007年 | 326篇 |
2006年 | 263篇 |
2005年 | 292篇 |
2004年 | 250篇 |
2003年 | 191篇 |
2002年 | 173篇 |
2001年 | 29篇 |
2000年 | 19篇 |
1999年 | 38篇 |
1998年 | 38篇 |
1997年 | 25篇 |
1996年 | 22篇 |
1995年 | 16篇 |
1994年 | 15篇 |
1993年 | 13篇 |
1992年 | 11篇 |
1991年 | 11篇 |
1990年 | 7篇 |
1989年 | 8篇 |
1988年 | 8篇 |
1987年 | 8篇 |
1986年 | 5篇 |
1985年 | 9篇 |
1984年 | 5篇 |
1982年 | 8篇 |
1981年 | 6篇 |
1980年 | 9篇 |
1979年 | 6篇 |
1978年 | 11篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1975年 | 4篇 |
1970年 | 8篇 |
排序方式: 共有5421条查询结果,搜索用时 418 毫秒
101.
102.
Variations in the morphology of pancreas are not very common. We observed a rare variant of the uncinate process of the pancreas that extended in the mesentery of the small intestine. After its origin from the lower part of the head of the pancreas, the mesenteric process (MP) passed over the third part of the duodenum to enter the mesentery of the jejunum and ileum and extended up to the level of the pelvic brim. The branches of the superior mesenteric vessels were embedded in the extended MP of the pancreas. This aberrant extension of the pancreas was drained by a narrow duct, which joined the main pancreatic duct inside the head. We did not observe a separate uncinate process arising from the head. On histology normal acini and endocrine cells were observed in the extension. This variant is important as symptoms of pancreatic disease from such extensions may be confused with other commonly encountered acute or chronic abdominal conditions. 相似文献
103.
Zobair Younossi Maria Stepanova Arun J. Sanyal Stephen A. Harrison Vlad Ratziu Manal F. Abdelmalek Anna Mae Diehl Stephen Caldwell Mitchell L. Shiffman Raul Aguilar Schall Bryan McColgan G. Mani Subramanian Robert P. Myers Andrew Muir Nezam H. Afdhal Jaime Bosch Zachary Goodman 《Journal of hepatology》2018,68(6):1365-1370
104.
105.
Prosthetic Rehabilitation Following Socket Reconstruction with Blair‐Brown Graft and Conformer Therapy for Management of Severe Post‐Enucleation Socket Syndrome – A Clinical Report
下载免费PDF全文
![点击此处可从《Journal of prosthodontics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Himanshi Aggarwal MDS Saumyendra V. Singh MDS Pradeep Kumar MDS Arun Kumar Singh M.Ch. 《Journal of prosthodontics》2015,24(4):329-333
One of the most common tumors of the eye diagnosed in childhood is retinoblastoma, which mandates enucleation with adjunctive chemotherapy and radiotherapy to save the patient's life. The most common late enucleation complication is post‐enucleation socket syndrome (PESS), which poses a management dilemma for the prosthodontist and surgeon, along with being a major esthetic concern for the patient. The reconstruction of such sockets is complex. The purpose of this clinical report is to describe the rehabilitation of such a pediatric patient with severe PESS. The patient was successfully rehabilitated by presurgical conformer therapy, socket reconstruction surgery with non‐meshed intermediate split thickness skin graft (STSG)/Blair‐Brown graft, and postsurgical conformer stent. This was followed by fabrication of a custom ocular prosthesis, to achieve favorable functional, physical, and psychological effects. 相似文献
106.
Effect of Physician Delegation to Other Healthcare Providers on the Quality of Care for Geriatric Conditions
下载免费PDF全文
![点击此处可从《Journal of the American Geriatrics Society》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Brian J. Lichtenstein MD David B. Reuben MD Arun S. Karlamangla MD PhD Weijuan Han MSPH Carol P. Roth RN MPH Neil S. Wenger MD MPH 《Journal of the American Geriatrics Society》2015,63(10):2164-2170
The quality of care of older adults in the United States has been consistently shown to be inadequate. This gap between recommended and actual care provides an opportunity to improve the value of health care for older adults. Prior work from the Assessing Care of Vulnerable Elders (ACOVE) investigators first defined, and then sought to improve, clinical practice for common geriatric conditions. A critical component of the ACOVE intervention for practice improvement was an emphasis on the delegation of specific care processes, but the independent effect of delegation on the quality of care has not been evaluated. This study analyzed the pooled results of prior ACOVE projects from 1998 to 2010. Totaled, these studies included 4,776 individuals aged 65 and older of mixed demographic backgrounds and 16,204 ACOVE quality indicators (QIs) for three geriatric conditions: falls, urinary incontinence, and dementia. In unadjusted analyses, QI pass probabilities were 0.36 for physician‐performed tasks, 0.55 for nurse practitioner (NP)‐, physician assistant (PA)‐, and registered nurse (RN)‐performed tasks; and 0.61 for medical assistant– and licensed vocational nurse–performed tasks. In multiply adjusted models, the independent pass‐probability effect of delegation to NPs, PAs, and RNs was 1.37 (P = .05). These findings suggest that delegation of selected tasks to nonphysician healthcare providers is associated with higher quality of care for these geriatric conditions in community practices and supports the value of interdisciplinary team management for common outpatient conditions in older adults. 相似文献
107.
Genotype–Phenotype Correlations by Ethnicity and Mutation Location in BRCA Mutation Carriers
下载免费PDF全文
![点击此处可从《The breast journal》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Soley Bayraktar MD MBA Michelle Jackson MS Angelica M. Gutierrez‐Barrera MS Diane Liu MS Funda Meric‐Bernstam MD Amanda Brandt MS Ashley Woodson MS Jennifer Litton MD Karen H. Lu MD Vicente Valero MD Banu K. Arun MD 《The breast journal》2015,21(3):260-267
The genotype–phenotype correlations of the specific BRCA1 and BRCA2 mutations in multi‐ethnic populations in USA have not yet been fully investigated. This study was designed to evaluate the effects of ethnicity at specific mutation locations and breast/ovarian cancer phenotypes. Our cohort included 445 women with different ethnic backgrounds who underwent BRCA genetic testing between 1997 and 2010. Known clinical and pathologic characteristics were compared with Chi‐Square Analysis or Fisher's Exact test as appropriate. The three most common mutation locations in BRCA1 (exons 2, 11, and 20) and BRCA2 (exons 10, 11, and 25) genes were chosen. Prevalence of BRCA1 exon 2 mutations were significantly higher in Ashkenazi Jewish (AJ) women compared to Caucasians (41% versus 15%; p = 0.001). Similarly, AJ women with breast cancer were more likely to have BRCA1 exon 2 mutation (47% positivity in AJ women versus 0–12.5% positivity in other ethnicities; p = 0.004). Women carrying the exon 20 BRCA1 mutation had the highest probability of having combined breast and ovarian cancers compared to women carrying other exon mutations (p = 0.05). The median age at initial cancer diagnosis, phenotypic features of breast cancer tumors, and overall survival did not vary significantly by ethnicity or mutation location. Our data suggest that ethnicity does not affect age of onset, overall survival or confer different risks of breast and ovarian cancer development in BRCA carriers. These results also suggest that women carrying the exon 20 BRCA1 mutation may warrant mutation‐specific counseling and be more aggressively managed for risk reduction. 相似文献
108.
109.
Gaston I Johnson KJ Oda T Bhat A Reis M Langdon W Shen L Deininger MW Druker BJ 《Experimental hematology》2004,32(1):113-121
Cbl is one of the major tyrosine-phosphorylated proteins in Bcr-Abl-expressing cells. A direct association between the SH2 domain of Bcr-Abl and tyrosine-phosphorylated Cbl has been demonstrated. The purpose of this study was to determine if and how unphosphorylated Cbl and Bcr-Abl may associate.Interactions between Cbl and Bcr-Abl were investigated in yeast two- and three-hybrid systems, gel overlay assays, and immunoprecipitates from mammalian cells expressing wild-type and the Y177F mutant of Bcr-Abl.No direct interaction between Bcr-Abl and unphosphorylated Cbl was observed. Bcr-Abl did, however, associate with Grb2, an adaptor protein that binds tyrosine 177 of Bcr-Abl. Additionally, Grb2 interacted with Cbl. In a yeast three-hybrid assay, Grb2 mediated an interaction between Cbl and Bcr-Abl that was dependent on a functional Grb2 binding site. This interaction was confirmed in vitro using purified proteins. In cells expressing Bcr-Abl with a mutation in the Grb2 binding site, binding of Cbl to Bcr-Abl was significantly reduced, but Cbl tyrosine phosphorylation was maintained. Imatinib treatment of these cells further reduced but did not abrogate Cbl binding, reflecting residual kinase activity.Multiple phosphotyrosine-dependent and -independent interactions stabilize the interaction between Cbl and Abl. Grb2 or another, yet unidentified, protein may mediate an initial interaction between Cbl and Bcr-Abl that is independent of Cbl tyrosine phosphorylation. Following this initial interaction, Cbl can then become tyrosine phosphorylated and interact with the SH2 domain of Bcr-Abl, further stabilizing the complex. 相似文献
110.
Benjamin Poh Paul Cashin Kaye Bowers Travis Ackermann Yeng Kwang Tay Arun Dhir Daniel Croagh 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2014,16(7):629-634