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Ryan K. Kaple MD Arash Salemi MD S. Chiu Wong MD 《Catheterization and cardiovascular interventions》2017,89(3):499-501
Transcatheter aortic valve replacement is an approved treatment for select patients with severe aortic stenosis. A rare complication of self‐expanding transcatheter heart valves (THVs) is infolding of the valve stent frame, which results in a malopposed segment, perivalvular aortic insufficiency, and possibly leaflet dysfunction. We report here a successful case of balloon valvuloplasty treatment for severe infolding of a self‐expandable THV in the aortic position, restoring stent frame geometry and leaflet function. © 2015 Wiley Periodicals, Inc. 相似文献
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Mohammad Reza Raoufy Shahryar Gharibzadeh Reza Abbasifar Behrad Radmehr Afshin Akhondzadeh Basti Arash Abbasifar Ramin Khaksar 《Comparative clinical pathology》2011,20(5):507-512
Salmonella is the most important cause of bacterial food-borne disease outbreaks in the world. In this study, we have trained and validated
artificial neural networks (ANNs) to predict the combined effect of Zataria multiflora essential oil (EO), pH, and temperature on the probability percentage of growth initiation (log P%) of Salmonella. Z. multiflora was collected in the Fars province of Iran. Lyophilized cultures of Salmonella typhimurium ATCC 25923 was used in this study. This design included four levels of EO (0.0, 0.015, 0.03, and 0.06%), three levels of
pH (5.5,6, and 7.3), three storage temperatures (35, 25, and 15°C), and repeated observations (18 times) for growth in brain
heart infusion broth for up to 43 days. We have designed a standard and the so-called feed-forward ANN, including four input
neurons, eight neuron in hidden layer, and one output neuron to predict the combined effect of Z. multiflora EO, pH, and temperature on the probability percentage of growth initiation (log P%) of S.typhimurium. The mean and standard deviation of ANN and real outputs were −2.9771 ± 2.43 and −2.9722 ± 2.39, respectively. The mean differences
(and 95% CIs) between the ANN and real outputs were 0.0049 (0.0009–0.0089). Result showed better prediction compare to the
previous study(R = 0.998). 相似文献
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Arash Arya Majid Haghjoo Zahra Emkanjoo Mohammad Reza Dehghani Mohammad Ali Sadr-Ameli 《Journal of interventional cardiac electrophysiology》2006,17(1):59-63
Objective We conducted this study to compare the rate of ≥1 inappropriate therapy between ICDs from two manufacturers which use different
discriminatory protocols.
Method One hundred sixty two patients (mean age 58 ± 13 years, 126 male) who received ICDs between January 2001 and 2005 were included
in the study. Clinical, electrocardiographic, and ICD stored data and electrograms were collected and analyzed. Immediately
after implantation all the detection and discrimination criteria were activated with the nominal values in order to compare the two discriminatory protocols under the default manufacturer’s settings.
Results During the follow up period of 14.3 ± 10 months, 49 (30%) patients received ≥1 inappropriate ICD therapy. The rate of ≥1 inappropriate
ICD therapy in manufacturer A and B ICDs was 26% (n = 29) and 41% (n = 20), respectively. Comparing the rate of ≥1 inappropriate ICD therapy between the two groups by Kaplan–Meier analysis and
the log rank test resulted in P = 0.04.
Conclusion Having all discriminatory variables activated with the nominal values, discriminatory performance differs between the two manufacturers. Further larger-scale studies are warranted to prospectively
compare the performance of various available ICDs’ discriminatory protocols, and define the optimum combination of discriminators in each ICD to decrease the rate of inappropriate therapy. 相似文献
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Fatemeh Beiraghdar Yunes Panahi Behzad Einollahi Eghlim Nemati Amirhossein Sahebkar Arash Hassanzadeh Hamid T. Khosroshahi Sima A. Azar Javid Safa Sadroddin R. Hashemi Jalal Etemadi Eisa T. Marzony Hamid Noshad 《Saudi Pharmaceutical Journal》2015,23(5):544-548
Background: The efficacy of human recombinant erythropoietins (rHuEPOs) in the treatment of anemia with different etiologies is proven. Development of biosimilar rHuEPO products with lower cost and wider availability is important for the care of anemic patients. Objective: The aim of the present study was to determine the bioequivalence and safety of a biosimilar rHuEPO (Pastopoitin®) and compare it with the innovator product Eprex®, as a standard rHuEPO. Methods: One hundred and seven anemic patients on stable hemodialysis were recruited to this randomized double-blind comparative trial and assigned to either subcutaneous Pastopoitin (n = 50) or Eprex (n = 57). Each study group received rHuEPO at a dose of 80–120 IU/kg/week in 2–3 divided doses for a period of 3 months. Hematologic parameters including Hemoglobin, hematocrit, RBC, EBC, platelet, MCV, MCH and MCHC were checked every 2 weeks. Blood iron, ferritin, TIBC, creatinine, BUN and electrolytes (Na, K, Ca and P) were evaluated monthly over the 3 months. Results: A significant increase in hemoglobin, hematocrit and RBC was observed by the end of study in both Pastopoitin and Eprex groups (p < 0.001). However, these factors were not significantly different between the groups, neither at baseline nor at the end of study (p > 0.05). Likewise, the groups were comparable regarding MCV, MCH, MCHC, iron, ferritin, TIBC, creatinine, BUN and electrolytes at baseline as well as at the end of trial. Adverse events were not serious and occurred with the same frequency in the study groups. Conclusion: Pastopoitin showed comparable efficacy and safety profile with Eprex in anemic patients on hemodialysis. Hence, Pastopoitin may be considered as a rHuEPO with a lower cost and wider availability compared with the innovator product Eprex. 相似文献
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Hassan Malekinejad Soheyl Varasteh Fatemeh Rahmani Hadi Cheraghi Arash Alizadeh Mehdi Behfar 《Toxin reviews》2015,34(2):101-108
This study was conducted to clarify the role of efflux transporter MRP2 in acetaminophen-induced hepatotoxicity in cats. Sixteen mixed bred male cats and four liver samples from mixed breed male dogs were used. The cats were assigned into four groups (n?=?4), received saline and 2, 10 and 50?mg/kg doses of acetaminophen orally for 14 days. Unlike the intact dogs, the MRP2 was not detectable in control cats. MRP2 at mRNA level was expressed in the liver of cats, which received the medium and high doses. Data suggest that the MRP2 expression may involve in the acetaminophen-induced hepatotoxicity in cats. 相似文献
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Somayeh Shahani Mostafa Rostamnezhad Vahid Ghaffari-rad Arash Ghasemi Tayyeb Allahverdi Pourfallah Seyed Jalal Hosseinimehr 《Dose-response》2015,13(1)
The radioprotective effect of Achillea millefolium L (ACM) extract was investigated against genotoxicity induced by ionizing radiation (IR) in human lymphocytes. Peripheral blood samples were collected from human volunteers and incubated with the methanolic extract of ACM at different concentrations (10, 50, 100, and 200 μg/mL) for 2 hours. At each dose point, the whole blood was exposed in vitro to 2.5 Gy of X-ray and then the lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis-blocked binucleated cell. Antioxidant capacity of the extract was determined using free radical-scavenging method. The treatment of lymphocytes with the extract showed a significant decrease in the incidence of micronuclei binucleated cells, as compared with similarly irradiated lymphocytes without any extract treatment. The maximum protection and decrease in frequency of micronuclei were observed at 200 μg/mL of ACM extract which completely protected genotoxicity induced by IR in human lymphocytes. Achillea millefolium extract exhibited concentration-dependent radical-scavenging activity on 1,1-diphenyl-2-picryl hydrazyl free radicals. These data suggest that the methanolic extract of ACM may play an important role in the protection of normal tissues against genetic damage induced by IR. 相似文献