全文获取类型
收费全文 | 122579篇 |
免费 | 47070篇 |
国内免费 | 260篇 |
专业分类
耳鼻咽喉 | 1978篇 |
儿科学 | 5909篇 |
妇产科学 | 1839篇 |
基础医学 | 22808篇 |
口腔科学 | 5755篇 |
临床医学 | 16895篇 |
内科学 | 33840篇 |
皮肤病学 | 8479篇 |
神经病学 | 18660篇 |
特种医学 | 3210篇 |
外科学 | 17570篇 |
综合类 | 297篇 |
现状与发展 | 1篇 |
一般理论 | 64篇 |
预防医学 | 8850篇 |
眼科学 | 2043篇 |
药学 | 9340篇 |
中国医学 | 1135篇 |
肿瘤学 | 11236篇 |
出版年
2024年 | 67篇 |
2023年 | 628篇 |
2022年 | 1126篇 |
2021年 | 3604篇 |
2020年 | 6283篇 |
2019年 | 12233篇 |
2018年 | 11764篇 |
2017年 | 12724篇 |
2016年 | 13518篇 |
2015年 | 13541篇 |
2014年 | 13969篇 |
2013年 | 15074篇 |
2012年 | 8380篇 |
2011年 | 8310篇 |
2010年 | 11077篇 |
2009年 | 7107篇 |
2008年 | 5263篇 |
2007年 | 4123篇 |
2006年 | 3835篇 |
2005年 | 3342篇 |
2004年 | 3156篇 |
2003年 | 2888篇 |
2002年 | 2759篇 |
2001年 | 965篇 |
2000年 | 835篇 |
1999年 | 483篇 |
1998年 | 352篇 |
1997年 | 294篇 |
1996年 | 204篇 |
1995年 | 191篇 |
1994年 | 192篇 |
1993年 | 147篇 |
1992年 | 106篇 |
1991年 | 88篇 |
1990年 | 65篇 |
1989年 | 81篇 |
1988年 | 77篇 |
1987年 | 70篇 |
1986年 | 63篇 |
1985年 | 63篇 |
1984年 | 87篇 |
1983年 | 69篇 |
1982年 | 79篇 |
1981年 | 68篇 |
1980年 | 61篇 |
1979年 | 29篇 |
1978年 | 38篇 |
1977年 | 36篇 |
1976年 | 26篇 |
1974年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 78 毫秒
991.
992.
993.
Nina Streefkerk Marianne J. Heins Jop C. Teepen Elizabeth A. M. Feijen Dorine Bresters Eline van Dulmen‐den Broeder Margriet van der Heiden‐van der Loo Marry M. van den Heuvel‐Eibrink Flora E. van Leeuwen Jacqueline J. Loonen Helena J. H. van der Pal Ccile M. Ronckers A. Birgitta Versluys Wim J. E. Tissing Joke C. Korevaar Leontien C. M. Kremer 《Pediatric blood & cancer》2019,66(8)
994.
995.
996.
Miriam B. G. Morrell Claudia Alvarez‐Florez Aiqian Zhang Eugenie S. Kleinerman Hannah Savage Enrica Marmonti Minjeong Park Angela Shaw Keri L. Schadler 《Pediatric blood & cancer》2019,66(9)
Recent studies in mouse models of cancer have shown that exercise improves tumor vascular function, thereby improving chemotherapy delivery and efficacy. However, the mechanisms underlying this improvement remain unclear and the effect of exercise on Ewing sarcoma (ES), a pediatric bone and soft tissue cancer, is unknown. The effect of exercise on tumor vascular hyperpermeability, which inversely correlates with drug delivery to the tumor, has also not been evaluated. We hypothesized that exercise improves chemotherapy efficacy by enhancing its delivery through improving tumor vascular permeability. We treated ES‐bearing mice with doxorubicin with or without moderate treadmill exercise. Exercise did not significantly alter ES tumor vessel morphology. However, compared to control mice, tumors of exercised mice had significantly reduced hyperpermeability, significantly decreased hypoxia, and higher doxorubicin penetration. Compared to doxorubicin alone, doxorubicin plus exercise inhibited tumor growth more efficiently. We evaluated endothelial cell sphingosine‐1‐phosphate receptors 1 and 2 (S1PR1 and S1PR2) as potential mediators of the improved vascular permeability and increased function afforded by exercise. Relative to tumors from control mice, vessels in tumors from exercised mice had increased S1PR1 and decreased S1PR2 expression. Our results support a model in which exercise remodels ES vasculature to reduce vessel hyperpermeability, potentially via modulation of S1PR1 and S1PR2, thereby improving doxorubicin delivery and inhibiting tumor growth more than doxorubicin alone does. Our data suggest moderate aerobic exercise should be tested in clinical trials as a potentially useful adjuvant to standard chemotherapy for patients with ES. 相似文献
997.
Marielle E. Yohe Christine M. Heske Elizabeth Stewart Peter C. Adamson Nabil Ahmed Cristina R. Antonescu Eleanor Chen Natalie Collins Alan Ehrlich Rene L. Galindo Berkley E. Gryder Heidi Hahn Sharon Hammond Mark E. Hatley Douglas S. Hawkins Madeline N. Hayes Andrea Hayes‐Jordan Lee J. Helman Simone Hettmer Myron S. Ignatius Charles Keller Javed Khan David G. Kirsch Corinne M. Linardic Philip J. Lupo Rossella Rota Jack F. Shern Janet Shipley Sivasish Sindiri Stephen J. Tapscott Christopher R. Vakoc Leonard H. Wexler David M. Langenau 《Pediatric blood & cancer》2019,66(10)
Overall survival rates for pediatric patients with high‐risk or relapsed rhabdomyosarcoma (RMS) have not improved significantly since the 1980s. Recent studies have identified a number of targetable vulnerabilities in RMS, but these discoveries have infrequently translated into clinical trials. We propose streamlining the process by which agents are selected for clinical evaluation in RMS. We believe that strong consideration should be given to the development of combination therapies that add biologically targeted agents to conventional cytotoxic drugs. One example of this type of combination is the addition of the WEE1 inhibitor AZD1775 to the conventional cytotoxic chemotherapeutics, vincristine and irinotecan. 相似文献
998.
Christiane Al‐Haddad Ziad Bashour Lina Farah Layal Bayram Zeina Merabe Riad Ma'luf Ramzi Alameddine Toufic Eid Fadi Geara Matthew Wilson Rachel Brennan Sima Jeha Khaled Ghanem Rasha Al Yousef Roula Farah Peter Noun Nabil Yassine Adlette Inati Samar Muwakkit Miguel Abboud Nidale Tarek Dima Hamideh Raya Saab 《Pediatric blood & cancer》2019,66(11)
Retinoblastoma is an ocular tumor that occurs in young children, in either heritable or sporadic manner. The relative rarity of retinoblastoma, and the need for expensive equipment, anesthesia, and pediatric ophthalmologic expertise, are barriers for effective treatment in developing countries. Also, with an average age‐adjusted incidence of two to five cases per million children, patient number limits development of local expertise in countries with small populations. Lebanon is a small country with a population of approximately 4.5 million. In 2012, a comprehensive retinoblastoma program was formalized at the Children's Cancer Institute (CCI) at the American University of Beirut Medical Center, and resources were allocated for efficient interdisciplinary coordination to attract patients from neighboring countries such as Syria and Iraq, where such specialized therapy is also lacking. Through this program, care was coordinated across hospitals and borders such that patients would receive scheduled chemotherapy at their institution, and monthly retinal examinations and focal laser therapy at the CCI in Lebanon. Our results show the feasibility of successful collaboration across borders, with excellent patient and physician adherence to treatment plans. This was accompanied by an increase in patient referrals, which enables continued expertise development. However, the majority of patients presented with advanced intraocular disease, necessitating enucleation in 90% of eyes in unilateral cases, and more than 50% of eyes in bilateral cases. Future efforts need to focus on expanding the program that reaches to additional hospitals in both countries, and promoting early diagnosis, for further improvement of globe salvage rates. 相似文献
999.
1000.
Anna M. Hood Allison A. King Melanie E. Fields Andria L. Ford Kristin P. Guilliams Monica L. Hulbert Jin‐Moo Lee Desiree A. White 《Pediatric blood & cancer》2019,66(10)
Individuals with sickle cell disease (SCD) experience cognitive deficits; however, it remains unclear whether medical treatments for SCD improve cognition. Given that executive abilities are typically impaired in individuals with SCD, they were the focus of the current study. Our primary hypothesis was that executive abilities would be higher acutely soon after a blood transfusion in children and young adults with SCD. We used tests from the NIH Toolbox to assess executive abilities in 27 participants with SCD receiving chronic transfusion in comparison to 34 participants with SCD receiving hydroxyurea (HU) and 41 non‐SCD demographically matched controls, all of whom were tested at two time points. Participants in the transfusion group completed cognitive testing within 3 days after a transfusion (soon after transfusion) and then within 3 days before their next transfusion (long after transfusion) over an interval of 3‐7 weeks. We found that executive abilities were significantly poorer for the transfusion and HU groups than for the control group. In support of our primary hypothesis, executive abilities for the transfusion group were significantly better soon after a transfusion compared to long after a transfusion, χ2(1) = 17.8, P < .0001. Our results demonstrate that executive abilities were higher acutely following a blood transfusion. These findings have implications for daily functioning, medical decision making, and academic achievement in children and young adults with SCD. 相似文献