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51.
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Alfredo Vicinanza Anissa Messaaoui Sylvie Tenoutasse Harry Dorchy 《Pediatric diabetes》2019,20(5):584-593
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C1q binding is not an independent risk factor for kidney allograft loss after an acute antibody‐mediated rejection episode: a retrospective cohort study 下载免费PDF全文
Anissa Moktefi Juliette Parisot Dominique Desvaux Florence Canoui‐Poitrine Isabelle Brocheriou Julie Peltier Vincent Audard Tomek Kofman Caroline Suberbielle Philippe Lang Eric Rondeau Philippe Grimbert Marie Matignon 《Transplant international》2017,30(3):277-287
After kidney transplantation, C4d is an incomplete marker of acute antibody‐mediated rejection (AMR) and C1q‐binding donor‐specific antibodies (DSA) have been associated with allograft survival. However, the impact on allograft survival of C1q+ DSA after clinical AMR has not been studied yet. We analysed retrospectively in clinical AMR C4d staining and C1q‐binding impact on allograft survival. We compared clinical, histological and serological features of C4d− and C4d+ AMR, C1q+ and C1q− DSA AMR and analysed C4d and C1q‐binding impact on allograft survival. Among 500 for‐cause kidney allograft biopsies, 48 fulfilled AMR criteria. C4d+ AMR [N = 18 (37.5%)] have significantly higher number class I DSA (P = 0.02), higher microvascular score (P = 0.02) and more transplant glomerulopathy (P = 0.04). C1q+ AMR [N = 20 (44%)] presented with significantly more class I and class II DSA (P = 0.005 and 0.04) and C4d+ staining (P = 0.01). Graft losses were significantly higher in the C4d+ group (P = 0.04) but similar in C1q groups. C4d+ but not C1q+ binding was an independent risk factor for graft loss [HR = 2.65; (1.11–6.34); P = 0.028]. In our cohort of clinical AMR, C4d+ staining but not C1q+ binding is an independent risk factor for graft loss. Allograft loss and patient survival were similar in C1q+ and C1q− AMR. 相似文献
54.
Eric J. Hawkins Aline M. K. Lott Carol A. Malte Anissa N. Frank Brittney Hamilton George G. Sayre 《Journal of addictive diseases》2017,36(3):193-206
Although care management approaches have potential to improve clinical outcomes and reduce high health care costs of patients with complex substance use disorders, characterized by high psychosocial, psychological, and/or medical needs and high acute health care utilization, little is known about patients' perspectives or experiences with these interventions. The objectives of this study were to identify barriers and facilitators to patient engagement in care management services for complex substance use disorders from patients' perspectives. This pilot study invited 22 men with complex substance use disorders and high health care utilization who were enrolled in a 1-year open trial of a Care Management Model to complete semi-structured interviews at 1- and 3-months post-baseline. Interviews were recorded, transcribed, and analyzed using template analysis. Five themes related to engagement were identified: barriers to conventional substance use disorder treatment, facilitators of care management services, patient–provider relationship, patient-related factors, and enhancements to a Care Management Model. Results highlighted the importance of the patient–provider relationship, individual visits with providers, flexible and personalized treatment, and a focus on recovery over abstinence in promoting patient engagement in care management services. Results also highlighted a need for increased outreach and assistance with housing and transit to treatment. Patients' perspectives support key elements of the care management services that are designed to facilitate patient engagement and suggest the need for additional outreach and assistance with obtaining shelter and transportation. Additional research is needed to evaluate if care management approaches enhance retention, improve outcomes, and reduce health care utilization of patients with complex and chronic substance use disorders. 相似文献
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Erwan Salaun Anissa Touil Sandrine Hubert Jean-Paul Casalta Frédérique Gouriet Emmanuelle Robinet-Borgomano Emilie Doche Nadia Laksiri Caroline Rey Cécile Lavoute Sébastien Renard Hervé Brunel Anne-Claire Casalta Julie Pradier Jean-François Avierinos Hubert Lepidi Laurence Camoin-Jau Alberto Riberi Gilbert Habib 《Archives of Cardiovascular Diseases》2018,111(12):712-721
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Intraportal islet transplantation has proven to be efficacious in preventing severe hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes. Multiple islet infusions are often required to achieve and maintain insulin independence. Many challenges remain in clinical islet transplantation, including substantial islet cell loss early and late after islet infusion. Contributions to graft loss include the instant blood-mediated inflammatory reaction, potent host auto- and alloimmune responses, and beta cell toxicity from immunosuppressive agents. Protective strategies are being tested to circumvent several of these events including exploration of alternative transplantation sites, stem cell-derived insulin producing cell therapies, co-transplantation with mesenchymal stem cells or exploration of novel immune protective agents. Herein, we provide a brief introduction and history of islet cell transplantation, limitations associated with this procedure and methods to alleviate islet cell loss as a means to improve engraftment outcomes. 相似文献
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N. Ahbeddou K. El Alaoui Taoussi A. Ibrahimi E.H. Ait Ben Haddou W. Regragui A. Benomar M. Yahyaoui 《Revue neurologique》2018,174(5):313-318
Objective
The aim of this study was to describe the clinical, biological and radiological characteristics of patients with syphilitic vasculitis, and to assess the outcome after treatment.Methodology
A retrospective review was carried out based on the records of patients with ischemic stroke, and reactive CSF TPHA and VDRL results. None of these patients showed symptoms of any other diseases or had received high doses of penicillin.Results
A total of 53 patients with stroke met the diagnostic criteria for syphilitic arteritis. Their average age was 41 ± 12 years. Nine patients had a history of genital ulcer (17%), and the median duration of illness after presenting a chancre was 8 [range: 1–14] years. A prodromal syndrome was seen in 27 patients (50.9%) and included changes in mental status in 14 patients (26.4%), seizures in 10 cases (18.9%), headache in eight (15.1%) and memory loss in seven (13.2%). Neurological events included focal motor deficits in 29 cases (54.7%), ataxia in 11 (20.8%) and movement disorders in 15 (28.3%). HIV serology was performed in 31 patients and proved negative in every case. Disease evolution was generally favorable: 12 patients (22.6%) were autonomous at the time of hospital discharge; 29 (54.7%) had partially recovered; and only seven (13.2%) still had signs of severe sequelae.Conclusion
A diagnosis of syphilitic stroke should be suspected in young patients as a manifestation of syphilis, and tests for neurosyphilis should be routine in neurology departments to make a prompt diagnosis, thereby preventing psychological sequelae. 相似文献59.
Marwa Sayeb PhD Zied Riahi PhD Nadia Laroussi PhD Crystel Bonnet PhD Lilia Romdhane PhD Rahma Mkaouar PhD Anissa Zaouak MD Jihene Marrakchi MD Ghaith Abdessalem PhD Olfa Messaoud PhD Oussema Bouchniba MS Nacer Ghilane MS Mourad Mokni MD Ghazi Besbes MD Houda Yacoub-Youssef PhD Christine Petit MD PhD Sonia Abdelhak PhD 《International journal of dermatology》2019,58(12):1439-1443
60.