全文获取类型
收费全文 | 5793篇 |
免费 | 388篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 171篇 |
妇产科学 | 147篇 |
基础医学 | 833篇 |
口腔科学 | 83篇 |
临床医学 | 611篇 |
内科学 | 1291篇 |
皮肤病学 | 116篇 |
神经病学 | 555篇 |
特种医学 | 90篇 |
外科学 | 547篇 |
综合类 | 51篇 |
一般理论 | 3篇 |
预防医学 | 745篇 |
眼科学 | 89篇 |
药学 | 398篇 |
中国医学 | 32篇 |
肿瘤学 | 388篇 |
出版年
2024年 | 12篇 |
2023年 | 88篇 |
2022年 | 131篇 |
2021年 | 272篇 |
2020年 | 162篇 |
2019年 | 218篇 |
2018年 | 233篇 |
2017年 | 167篇 |
2016年 | 141篇 |
2015年 | 203篇 |
2014年 | 229篇 |
2013年 | 336篇 |
2012年 | 513篇 |
2011年 | 472篇 |
2010年 | 296篇 |
2009年 | 249篇 |
2008年 | 386篇 |
2007年 | 350篇 |
2006年 | 344篇 |
2005年 | 333篇 |
2004年 | 297篇 |
2003年 | 242篇 |
2002年 | 224篇 |
2001年 | 27篇 |
2000年 | 20篇 |
1999年 | 32篇 |
1998年 | 33篇 |
1997年 | 16篇 |
1996年 | 26篇 |
1995年 | 26篇 |
1994年 | 16篇 |
1993年 | 15篇 |
1992年 | 6篇 |
1991年 | 10篇 |
1990年 | 5篇 |
1989年 | 7篇 |
1988年 | 10篇 |
1987年 | 6篇 |
1986年 | 7篇 |
1985年 | 2篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1971年 | 2篇 |
1961年 | 1篇 |
排序方式: 共有6199条查询结果,搜索用时 15 毫秒
31.
Jeoffrey A. Bispham Allyson S. Hughes Ludi Fan Magaly Perez-Nieves Alicia H. McAuliffe-Fogarty 《Clinical Diabetes》2021,39(2):153
There is a dearth of research characterizing the impact on a caregiver’s sleep when caring for a minor with type 1 diabetes. This study used focus groups of people with type 1 diabetes and caregivers of minors with type 1 diabetes to explore the experience of how diabetes affects sleep. The occurrence of both unanticipated and planned sleep disruptions led to the majority of participants reporting that their sleep was considerably affected by diabetes. Despite the improvement in blood glucose management that diabetes technology devices can provide, people with type 1 diabetes and their caregivers still report sleep disruption and sleep loss resulting from overnight diabetes management.The daily self-management behaviors involved in living with type 1 diabetes can be more difficult overnight for people with type 1 diabetes, caregivers, and other household members and can lead to sleep disruptions and emotional experiences such as worrying about severe hypoglycemia occurring during sleep. On average, people with type 1 diabetes experience nocturnal hypoglycemia 25% of the time (1). Emotional experiences can also include fear of hypoglycemia, which refers to extreme worry and anxiety-like symptoms experienced by people living with type 1 diabetes and their caregivers regarding hypoglycemia. Such feelings can result in negative diabetes management behaviors and negatively affect quality of life (2,3). Disturbances caused by diabetes device alarms and fear of hypoglycemia are common barriers to sleep for people with diabetes (4). Research suggests that interventions should be developed to target overnight glycemic management and fear of hypoglycemia to improve sleep quality (5). 相似文献
32.
Isolation of cross-reactive,subtype-specific monoclonal antibodies against influenza virus HA1 and HA2 hemagglutinin subunits 总被引:5,自引:0,他引:5
Summary The large (HA1) and small (HA2) subunits of influenza virus A/Vict/3/75 hemagglutinin were purified in denatured form by preparative electrophoresis. Both polypeptides were used to immunize mice from which monoclonal antibodies were obtained. These antibodies reacted not only with the corresponding hemagglutinin subunit but also with purified virions. When tested by radioimmunoassay against a panel of human viruses, most anti-HA1 and -HA2 antibodies behaved as subtype-specific, whereas anti-HA antibodies, raised against purified virus, were more restricted. The anti-subunit antibodies were negative in hemagglutination-inhibition and neutralization tests. The interest of these antibodies as reagents for research and diagnosis is discussed. 相似文献
33.
Alicia Aguilar-Martínez Marina Bosque-Prous Helena Gonzlez-Casals Ester Colillas-Malet Susanna Puigcorb Laura Esquius Albert Espelt 《Nutrients》2021,13(5)
Adolescence is a critical period in the consolidation of healthy lifestyles that can last into adulthood. To analyze changes in food consumption and eating behaviors in high-school adolescents during the first confinement, a cross-sectional study was conducted at the end of confinement in Spain. Changes in the frequency or quantity of consumption of different types of food and food-related behaviors were analyzed. Socioeconomic and health-related variables were also considered. To determine whether dietary changes were related to socioeconomic position (SEP), Poisson regression models with robust variance were estimated. Overall, there were some changes towards a healthier diet such as an increase in fruit consumption (38.9%) and a decrease in the consumption of soft drinks (49.8%), sweets and pastries (39.3%), and convenience foods (49.2%). Some changes, however, were related to less healthy behaviors, such as a more irregular pattern of meal distribution (39.9%) or an increase in snacking between meals (56.4%). Changes towards less healthy eating were also related to students’ SEP. The risk of worsening the diet was found to be 21% higher in adolescents from a more disadvantaged SEP. Future public policies could be adapted to avoid increasing nutritional and health inequalities. 相似文献
34.
Camille G. Apple Elizabeth S. Miller Kolenkode B. Kannan Julie A. Stortz Tyler J. Loftus Maria Cecilia Lopez Hari K. Parvataneni Matthew Patrick Jennifer E. Hagen Henry V. Baker Philip A. Efron Alicia M. Mohr 《Surgery》2021,169(5):1206-1212
BackgroundPrevious data has shown that severe traumatic injury is associated with bone marrow dysfunction, which manifests as persistent injury-associated anemia. This study sought to identify whether the expression of erythropoiesis-related microRNAs were altered in the bone marrow of trauma patients to determine if these microRNAs play a role in persistent injury-associated anemia.MethodsBone marrow was collected from severely injured trauma patients who underwent fracture fixation as well as patients who underwent elective hip replacement. There were 27 trauma patients and 10 controls analyzed. Total RNA and microRNA were isolated from CD34-positive cells using the RNeasy Plus Mini kit, and genome-wide microRNA expression patterns were assayed. Genes with significant expression differences were found using BRB-ArrayTools with a significance of P < .01.ResultsThere were marked differences in expression of 108 microRNAs in the trauma group when compared with hip replacement patients. Four of these microRNAs play a role in regulating erythropoiesis: microRNA-150, microRNA-223, microRNA15a, and microRNA-24. These microRNAs were all upregulated significantly, with trauma/hip replacement fold changes of 1.7, 1.8, 1.2, and 1.2 respectively, and all act to suppress or regulate erythropoiesis.ConclusionAssessment of the bone marrow microRNA profile in trauma patients compared to those undergoing elective hip replacement revealed the differential expression of microRNA-150, microRNA-223, microRNA-15a, and microRNA-24. These microRNAs all play a role in decreased erythroid progenitor cell growth and provide important insight to the erythropoietic dysfunction seen after trauma. 相似文献
35.
Bateni Sarah B. Gingrich Alicia A. Kirane Amanda R. Sauder Candice A. M. Gholami Sepideh Bold Richard J. Meyers Frederick J. Canter Robert J. 《Annals of surgical oncology》2021,28(3):428-428
Annals of Surgical Oncology - 相似文献
36.
Maria Ruden Christopher H. Olivares Mathew Q. Fakhoury Alicia Roston Patricia P. Vidal Courtney M.P. Hollowell Sarah P. Psutka 《Urologic oncology》2021,39(1):73.e19-73.e25
PurposeTo compare the clinical presentation, treatment receipt, and oncologic outcomes between human immunodeficiency virus-seropositive (HIV+) and seronegative (HIV?) men with prostate cancer (CaP) matched by age, clinical stage, and race.Materials and methodsA retrospective review of 3,135 men treated for CaP from 2000 to 2016 was performed. HIV+ patients (N = 46) were matched 1:2 to 3 to HIV? men (N = 137) by age, race, and clinical stage. Clinicopathologic features and primary treatment received were compared between cohorts. Associations between HIV status and progression-free, cancer-specific, and overall survival were compared by HIV status using the Kaplan-Meier method and Cox proportional hazards analysis.ResultsAfter matching, men with and without HIV were similar with respect initial prostate-specific antigen, Gleason Sum, and Eastern Cooperative Oncology Group (ECOG) performance status. Among HIV+ men, 67.4% had a history of acquired immune deficiency syndrome, and 91.3% were on highly active antiretroviral therapy at CaP diagnosis. Among men with localized disease, HIV+ men were more likely to receive radiation (59.5% vs. 44.8%) or no therapy (13.5% vs. 4.3%) and less likely to receive surgery (16.2% vs. 30.2%), or to initiate active surveillance (10.8% vs. 16.4%; P = 0.04 overall). There were no differences in rates of clinical progression, development of castration resistance, or CaP death by HIV status. However, HIV+ status was associated with inferior overall survival (hazard ratio 2.89, P = 0.04).ConclusionsWhile most HIV+ patients had a history of acquired immune deficiency syndrome; HIV was well controlled in the majority of patients at the time of CaP diagnosis. While oncologic outcomes were similar between HIV+ and HIV? men, significant differences in treatment selection were observed. Further research is necessary to understand differences in treatment election by HIV status and to define optimal CaP treatment selection in men with HIV. 相似文献
37.
Daniel López-Padilla Francisco García-Río Adolfo Alonso-Arroyo Nuria Arenas Valls Alicia Cerezo Lajas Marta Corral Blanco Virginia Gallo González Milagros Llanos Flores María Martínez Redondo Natalia Martos Gisbert Elena Ojeda Castillejo Marta Padilla Bernáldez Marta Pérez Gallán Vania Prudencio Ribera Luis Puente Maestu Beatriz Recio Moreno Elena Rodríguez Jimeno Ana Sánchez Azofra José Ignacio de Granda-Orive 《Archivos de bronconeumologia》2021,57(2):146-147
38.
39.
Sautter FJ Brailey K Uddo MM Hamilton MF Beard MG Borges AH 《Journal of traumatic stress》1999,12(1):73-88
Symptoms of posttraumatic stress disorder (PTSD), psychosis, general psychopathology, role functioning, violence potential, and cognitive and emotional aspects of psychotic states were compared in three groups of veterans. Groups were defined on the basis of their DSM-IV diagnoses: Psychotic disorder and war-related PTSD, war-related PTSD without psychotic symptoms, and psychotic disorder without PTSD. Veterans with PTSD and a comorbid psychotic disorder showed significantly higher levels of positive symptoms of psychosis, general psychopathology, paranoia, and violent thoughts, feelings, and behaviors than the other two groups. These data show that patients with comorbid PTSD and psychotic disorder show levels of cognitive, emotional, and behavioral disturbance that far exceed the levels of disturbance seen in patients with PTSD without psychosis or in patients with psychotic disorder. 相似文献
40.
Fernandez AP Aronson S Toledano A Winkelmann J Saldivar J Feinstein SB 《Echocardiography (Mount Kisco, N.Y.)》1996,13(5):489-498
Videodensitometric analysis of myocardial contrast echocardiography is traditionally performed off line. Recently, an online contrast ultrasound analysis system, Acoustic Densitometry (Hewlett-Packard), was introduced. We compared pixel intensities acquired with Acoustic Densitometry to pixel intensities derived from videodensitometry. A tissue phantom was imaged in phase I using three transducer frequencies (2.5, 3.5, and 5.0 MHz). In phase II, an in vitro flowing tube model with various concentrations of Albunex® was imaged at two flow rates, 0.6 and 1.2 m/sec, and at two transducer frequencies, 2.5 and 3.5 MHz. The relationship between pixel intensities yielded by the two systems for identical ultrasound signals was determined with linear regression. Intensities derived with Acoustic Densitometry strongly correlated with those derived from the offline videodensitometry system. The intensities were related by a predictive multiplicative factor based on display characteristics of the two systems. These results suggest that semiquantitative, online perfusion analysis with Acoustic Densitometry is as sensitive as analysis offline with videodensitometry. 相似文献