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排序方式: 共有380条查询结果,搜索用时 31 毫秒
371.
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373.
F. Wang J. He S. Chen F. Qin B. Dai W. Zhang FM. Zhu HJ. Lv 《International journal of immunogenetics》2014,41(1):13-19
Umbilical cord blood (UCB) is a widely accepted source of progenitor cells, and now, many cord blood banks were established. Here, we analysed the HLA‐A, HLA‐B and HLA‐DRB1 allele and haplotype frequencies, HLA matching possibilities for searching potential donors and outcome of UCB transplantations in Zhejiang cord blood bank of China. A total of 6384 UCB units were characterized for 17 HLA‐A, 30 HLA‐B and 13 HLA‐DRB1 alleles at the first field resolution level. Additionally, B*14, B*15 and B*40 were typed to the second field level. A total of 1372 distinct A‐B‐DRB1 haplotypes were identified. The frequencies of 7 haplotypes were more than 1%, and 439 haplotypes were <0.01%. A*02‐B*46‐DRB1*09, A*33‐B*58‐DRB1*03 and A*30‐B*13‐DRB1*07 were the most common haplotypes, with frequencies of 4.4%, 3.3%, and 2.9%, respectively. Linkage disequilibrium(LD) analysis showed that there were 83 A‐B, 106 B‐DRB1, 54 A‐DRB1 haplotypes with positive LD, in which 51 A‐B, 60 B‐DRB1, 32 A‐DRB1 haplotypes exhibited a significant LD (P < 0.05). In 682 search requests, 12.9%, 40.0% and 42.7% of patients were found to have 6 of 6, 5 of 6 and 4 of 6 HLA‐A, HLA‐B and HLA‐DRB1 matching donors, respectively. A total of 30 UCB units were transplanted to 24 patients (3 patients not evaluated due to early death); 14 of 21 patients (66.7%) engrafted. This study reveals the HLA distribution and its transplantation application in the cord blood bank of Zhejiang province. These data can help to select potential UCB donors for transplantation and used to assess the scale of new cord blood banking endeavours. 相似文献
374.
Russell IJ Holman AJ Swick TJ Alvarez-Horine S Wang YG Guinta D;Sodium Oxybate - FM Study Group 《Pain》2011,152(5):1007-1017
This 14-week, phase 3, double-blind, randomized, controlled trial evaluated sodium oxybate (SXB) 4.5 and 6g per night versus placebo in patients with fibromyalgia (FM). SXB is the sodium salt of γ-hydroxybutyrate (GHB). GHB is an endogenous compound, synthesized from γ-aminobutyric acid (GABA) and found broadly in the central nervous system and body. Among 548 randomized patients, a ≥30% reduction in pain was experienced by 54.2% and 58.5% of patients treated with SXB 4.5 and 6g, respectively, versus 35.2% for placebo with a 100-mm Visual Analog Scale (VAS) (P<0.001 for both comparisons). Relative to placebo, both SXB doses significantly reduced fatigue (with a 100-mm VAS; P<0.001) and sleep disturbance (with the Jenkins Sleep Scale; P<0.001), and resulted in significant improvements in function as measured by the FM Impact Questionnaire (P=0.003 and P=0.001 for 4.5 and 6 g per night, respectively). On the Short-Form 36 Health Survey, SXB-related improvement was significant on the Physical, but not the Mental, Component Scale. The proportion of patients who reported a global improvement of "much" or "very much" better on the Patient Global Impression of Change was significantly greater in both SXB groups versus placebo (P<0.001). Headache, nausea, dizziness, vomiting, diarrhea, anxiety, and sinusitis were the most commonly reported adverse events, with an incidence at least twice that of placebo. These results expand the evidence from previous clinical trials suggesting that SXB is effective and safe in FM. 相似文献
375.
Longatto-Filho A Naud P Derchain SF Roteli-Martins C Tatti S Hammes LS Sarian LO Eržen M Branca M de Matos JC Gontijo R Maeda MY Lima T Costa S Syrjänen S Syrjänen K 《Virchows Archiv : an international journal of pathology》2012,460(6):577-585
We sought to evaluate the performance of diagnostic tools to establish an affordable setting for early detection of cervical cancer in developing countries. We compared the performance of different screening tests and their feasibility in a cohort of over 12,000 women: conventional Pap smear, liquid-based cytology, visual inspection with acetic acid (VIA), visual inspection with Iodine solution (VILI), cervicography, screening colposcopy, and high-risk human papillomavirus (HPV) testing (HR-HPV) collected by physician and by self-sampling. HR-HPV assay collected by the physician has the highest sensitivity (80 %), but high unnecessary referrals to colposcopy (15.1 %). HR-HPV test in self-sampling had a markedly lower (57.1 %) sensitivity. VIA, VILI, and cervicography had a poor sensitivity (47.4, 55, and 28.6 %, respectively). Colposcopy presented with sensitivity of 100 % in detecting CIN2+, but the lowest specificity (66.9 %). Co-testing with VIA and VILI Pap test increased the sensitivity of stand-alone Pap test from 71.6 to 87.1 % and 71.6 to 95 %, respectively, but with high number of unnecessary colposcopies. Co-testing with HR-HPV importantly increased the sensitivity of Pap test (to 86 %), but with high number of unnecessary colposcopies (17.5 %). Molecular tests adjunct to Pap test seems a realistic option to improve the detection of high-grade lesions in population-based screening programs. 相似文献
376.
SUETONIA C PALMER SANKAR D NAVANEETHAN GIOVANNI FM STRIPPOLI 《Nephrology (Carlton, Vic.)》2010,15(2):158-164
A systematic review provides the best summary of evidence for clinical decision‐making in nephrology by summarizing all the primary studies that evaluate a specific clinical question. By using rigorous and pre‐specified methods, conclusions about the overall effect of an intervention can be more reliable, precise and comprehensive in a systematic review than those derived from individual studies. In this article, we describe the key components of a systematic review and meta‐analysis. We summarize the features of a systematic review that should be looked for when considering the accuracy and validity of its results – particularly when applying the outcomes of a systematic review to a clinical question. 相似文献
377.
Daisy JA Janssen Martijn A Spruit Joan D Does Jos MGA Schols Emiel FM Wouters 《BMC palliative care》2010,9(1):6
COPD is nowadays the main indication for lung transplantation. In appropriately selected patients with end stage COPD, lung
transplantation may improve quality of life and prognosis of survival. However, patients with end stage COPD may die while
waiting for lung transplantation. Palliative care is important to address the needs of patients with end stage COPD. This
case report shows that in a patient with end stage COPD listed for lung transplantation offering palliative care and curative-restorative
care concurrently may be problematic. If the requirements to remain a transplantation candidate need to be met, the possibilities
for palliative care may be limited. Discussing the possibilities of palliative care and the patient's treatment preferences
is necessary to prevent that end-of-life care needs of COPD patients dying while listed for lung transplantation are not optimally
addressed. The patient's end-of-life care preferences may ask for a clear distinction between the period in which palliative
and curative-restorative care are offered concurrently and the end-of-life care period. This may be necessary to allow a patient
to spend the last stage of life according to his or her wishes, even when this implicates that lung transplantation is not
possible anymore and the patient will die because of end stage COPD. 相似文献
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379.
Ibrahim Al-Nasser Ashraf M Anwar Youssef FM Nosir Mohammed AR Chamsi-Pasha Aref Ajam Aymen Alqiriaqri Hassan Chamsi-Pasha 《Journal of cardiovascular magnetic resonance》2008,10(1):1-3
Aims
to investigate the association between admission hyperglycemia and myocardial damage in patients with ST-segment elevation myocardial infarction (STEMI) using Cardiac Magnetic Resonance (CMR).Methods
We analyzed 113 patients with STEMI treated with successful primary percutaneous coronary intervention. Admission hyperglycemia was defined as a glucose level ≥ 7.8 mmol/l. Contrast-enhanced CMR was performed between 3 and 7 days after reperfusion to evaluate left ventricular function and perfusion data after injection of gadolinium-DTPA. First-pass images (FP), providing assessment of microvascular obstruction and Late Gadolinium Enhanced images (DE), reflecting the extent of infarction, were investigated and the extent of transmural tissue damage was determined by visual scores.Results
Patients with a supramedian FP and DE scores more frequently had left anterior descending culprit artery (p = 0.02 and <0.001), multivessel disease (p = 0.02 for both) and hyperglycemia (p < 0.001). Moreover, they were characterized by higher levels of HbA1c (p = 0.01 and 0.04), peak plasma Creatine Kinase (p < 0.001), left ventricular end-systolic volume (p = 0.005 and <0.001), and lower left ventricular ejection fraction (p = 0.001 and <0.001). In a multivariate model, admission hyperglycemia remains independently associated with increased FP and DE scores.Conclusion
Our results show the existence of a strong relationship between glucose metabolism impairment and myocardial damage in patients with STEMI. Further studies are needed to show if aggressive glucose control improves myocardial perfusion, which could be assessed using CMR. 相似文献380.