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71.
Traditionally, diatoms have been regarded as providing the bulk of the food that sustains the marine food chain and important
fisheries. However, this view was challenged almost two decades ago on the basis of laboratory and field studies showing that
when copepods, the principal predators of diatoms, feed on certain diatom diets, they produce abnormal eggs that either fail
to develop to hatching or hatch into malformed (i.e. teratogenic) nauplii that die soon afterwards. Over the years, many explanations
have been advanced to explain the causes for reproductive failure in copepods and other marine and freshwater invertebrates
including diatom toxicity, or nutritional deficiency and poor assimilation of essential compounds in the animal gut. Here
we review the literature concerning the first possibility, that diatoms produce cytotoxic compounds responsible for growth
inhibition and teratogenic activity, potentially sabotaging future generations of grazers by inducing poor recruitment. The
cytotoxic compounds responsible for these effects are short chain polyunsaturated aldehydes (PUAs) and other oxygenated fatty
acid degradation products such as hydroxides, oxo-acids, and epoxyalcohols (collectively termed oxylipins) that are cleaved
from fatty acid precursors by enzymes activated within seconds after crushing of cells. Such toxins are suggested to have
multiple simultaneous functions in that they not only deter herbivore feeding but some also act as allelopathic agents against
other phytoplankton cells, thereby affecting the growth of competitors, and also signalling population-level cell death and
termination of blooms, with possible consequences for food web structure and community composition. Some oxylipins also play
a role in driving marine bacterial community diversity, with neutral, positive or negative interactions depending on the species,
thereby shaping the structure of bacterial communities during diatom blooms. Several reviews have already been published on
diatom-grazer interactions so this paper does not attempt to provide a comprehensive overview, but rather to consider some
of the more recent findings in this field. We also consider the role of diatom oxylipins in mediating physiological and ecological
processes in the plankton and the multiple simultaneous functions of these secondary metabolites. 相似文献
72.
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74.
Donna M. McDonald‐McGinn Don La Rossa David McGain Noah Federman Adrianna Vlachos Bertil E. Glader Steven E. McKenzie Jeffrey M. Lipton Elaine H. Zackai 《American journal of medical genetics. Part A》2001,101(3):268-274
We report on maternal first cousins with bilateral microtia, micrognathia, cleft palate and hematologic findings of Diamond‐Blackfan anemia (DBA). The similarity of findings shared between our cases and a female reported by Hasan and Inoue [ 1993 ] suggests that this is a distinctive syndrome, rather than a chance association. DBA is a heterogeneous disorder, caused in about 25% of cases by heterozygous mutations in the RPS19 gene (DBA1). Mutation analysis in our cases did not show an RPS19 mutation, and 2 alleles were present in each. Segregation analysis for DBA1 on chromosome 19 and DBA2 on 8p23 was not consistent with linkage. We conclude that this syndrome of microtia, cleft palate and DBA is not allelic to known DBA loci. © 2001 Wiley‐Liss, Inc. 相似文献
75.
Agnieszka Tkaczyk Piotr Jedziniak ukasz Zielonka Micha Dbrowski Piotr Ochodzki Adrianna Rudawska 《Toxins》2021,13(11)
This study applied multi-mycotoxin liquid chromatography with tandem mass spectrometric detection (LC-MS/MS) methods to determine the biomarkers of exposure in urine and serum samples from a dose-response study with pigs. The 24 studied pigs were divided into three groups: a control and two experimental ones (with different levels of feed contamination). They were exposed to feed prepared from cereals contaminated with deoxynivalenol (DON), zearalenone (ZEN), ochratoxin A (OTA) and citrinin (CIT) for 14 days. After that, both experimental groups received the same feed as the control group for the next 14 days to determine the kinetics of the disappearance of mycotoxin biomarkers. Urine samples were collected daily in the morning and blood samples—eight-times during the experiment. The study reported herein was the first prolonged exposure experiment for multiple mycotoxins like OTA and CIT in pigs. The urinary and serum levels of all biomarkers correlated well with the respective toxin intake; thereby demonstrating that they are suitable biomarkers of exposure in pigs. Urine is a good candidate to monitor DON, ZEN, OTA, CIT exposure while serum may be used to monitor DON, OTA and CIT. Additionally, OTA has even been quantified in both matrices in the experimental groups two weeks after changing the contaminated feed back to the control, this result differed from those produced by the other mycotoxins which were only quantified during the first two weeks. Therefore both matrices are suitable candidates to monitor prolonged OTA exposure in pigs. 相似文献
76.
Adrianna Kamiska Piotr Midlicki Karolina Kiebasa Jarosaw Serafin Joanna Srescek-Nazzal Rafa Jan Wrbel Agnieszka Wrblewska 《Materials》2021,14(24)
The work presents the synthesis of FeCl3-modified carbonaceous catalysts obtained from waste orange peel and their application in the oxidation of alpha-pinene in solvent-free reaction conditions. The use of waste orange peel as presented here (not described in the literature) is an effective and cheap way of managing this valuable and renewable biomass. FeCl3-modified carbonaceous materials were obtained by a two-stage method: in the first stage, activated carbon was obtained, and in the second stage, it was modified by FeCl3 in the presence of H3PO4 (three different molar ratios of these two compounds were used in the studies). The obtained FeCl3-modified carbon materials were subjected to detailed instrumental studies using the methods FT-IR (Fourier-transform Infrared Spectroscopy), XRD (X-ray Diffraction), SEM (Scanning Electron Microscope), EDXRF (Energy Dispersive X-ray Fluorescence) and XPS (X-ray Photoelectron Spectroscopy), while the textural properties of these materials were also studied, such as the specific surface area and total pore volume. Catalytic tests with the three modified activated carbons showed that the catalyst obtained with the participation of 6 M of FeCl3 and 3 M aqueous solutions of H3PO4 was the most active in the oxidation of alpha-pinene. Further tests (influence of temperature, amount of catalyst, and reaction time) with this catalyst made it possible to determine the most favorable conditions for conducting oxidation on this type of catalyst, and allowed study of the kinetics of this process. The most favorable conditions for the process were: temperature of 100 °C, catalyst content of 0.5 wt% and reaction time 120 min (very mild process conditions). The conversion of the organic raw material obtained under these conditions was 40 mol%, and the selectivity of the transformation to alpha-pinene oxide reached the value of 35 mol%. In addition to the epoxy compound, other valuable products, such as verbenone and verbenol, were formed while carrying out the process. 相似文献
77.
Agnieszka Wrblewska Jadwiga Grzeszczak Piotr Midlicki Karolina Kiebasa Marcin Kujbida Adrianna Kamiska Beata Michalkiewicz 《Materials》2021,14(24)
The work presents the results of studies on α-pinene oxidation over the TS-1 catalysts with different Ti content (in wt%): TS-1_1 (9.92), TS-1_2 (5.42), TS-1_3 (3.39) and TS-1_4 (3.08). No solvent was used in the oxidation studies, and molecular oxygen was used as the oxidizing agent. The effect of titanium content in the TS-1 catalyst, temperature, reaction time and amount of the catalyst in the reaction mixture on the conversion of α-pinene and the selectivities of appropriate products was investigated. It was found that it is most advantageous to carry out the process of α-pinene oxidation in the presence of the TS-1 catalyst with the titanium content of 5.42 wt% (TS-1_2), at the temperature of 85 °C, for 6 h and with the catalyst TS-1 content in the reaction mixture of 1 wt%. Under these conditions the conversion of α-pinene amounted to 34 mol%, and the selectivities of main products of α-pinene oxidation process were: α-pinene oxide (29 mol%), verbenol (15 mol%) and verbenone (12 mol%). In smaller quantities also campholenic aldehyde, trans-pinocarveol, myrtenal, myrtenol, L-carveol, carvone and 1,2-pinanediol were also formed. These products are of great practical importance in food, cosmetics, perfumery and medicine industries. Kinetic studies were also performed for the studied process. 相似文献
78.
Adrianna Sawiska Magorzata Tyszka-Czochara Pawe Serda Marcin Oszajca Magorzata Ruggiero-Mikoajczyk Katarzyna Pamin Robert Karcz Wiesaw asocha 《Materials》2022,15(1)
Two new organic-inorganic hybrid compounds containing dicarboxylic pyridine acids have been obtained and characterized. Both compounds are potassium oxidodiperoxidomolybdates with 2,6-dicarboxylicpyridine acid or 3,5-dicarboxylicpyridine acid moieties, respectively. The chemical formula for the first one is C14H7K3Mo2N2O18 denoted as K26dcpa, the second C7H4K1Mo1N1O11.5—K35dcpa. Their crystal structures were determined using single crystal (K26dcpa) or XRPD—X-ray powder diffraction techniques (K35dcpa). The purity of the compounds was confirmed by elemental analysis. Their thermal stability was determined with the use of non-ambient XRPD. In addition, they were examined by IR spectroscopy methods and catalytic activity studies were performed for them. Catalytic tests in the Baeyer–Villiger reaction and biological activity have been performed for eight compounds: K26dcpa, K35dcpa, and six peroxidomolybdates previously obtained by our group. The anti-proliferative activity of peroxidomolybdenum compounds after 24 h of incubation was studied in vitro against three selected human tumor cell lines (SW620, LoVo, HEP G2) and normal human cells (fibroblasts). The data were expressed as IC50 values. The structure of the investigated oxodiperoxomolybdenum compounds was shown to have influence on the biological activity and catalytic properties. It has been shown that the newly-obtained compound, K35dcpa, is a very efficient catalyst in the Baeyer–Villiger reaction. The best biological activity results were obtained for Na-picO (previously obtained by us), which is a very effective anti-cancer agent towards SW 620 colorectal adenocarcinoma cells. 相似文献
79.
Anh N. Ly Russell Manzanero Adrianna Maliga Sarah M. Gunter Shannon E. Ronca Emily Zielinski-Gutierrez Francis Morey Kim Bautista Andres Espinosa-Bode Beatriz Lpez Loren Cadena Rafael C. Fuentes Timothy A. Erickson Flor M. Munoz Joy Mackey Gerhaldine Morazn Kristy O. Murray 《Viruses》2022,14(4)
The Acute Febrile Illness (AFI) Surveillance Network in Belize is a country-wide active surveillance program aimed at diagnosing vector-borne, respiratory, and enteric pathogens among patients presenting to 11 participating hospitals and clinics with new onset fever. This study describes the epidemiology of dengue virus (DENV) infections in Belize diagnosed through AFI surveillance in 2020. Of the 894 patients enrolled and PCR-tested for DENV in this period, 44 DENV-positive cases (5%) were identified. All four DENV serotypes were detected, with two cases testing positive for DENV serotype 4, which is the first report of this serotype in Belize since 2004. The majority of DENV cases (66%) were diagnosed in the Belize District, which contains the largest urban center in the country (Belize City). Positive cases were detected between January 2020 and September 2020, with the majority (89%) diagnosed during the dry season between January and April, unlike years prior when cases were more often diagnosed during the wet season. Clinical signs and symptoms varied slightly between DENV serotypes. Active surveillance of DENV among AFI cases provides insight into the epidemiologic and clinical characteristics of DENV in Belize. This information is important for informing public health interventions to mitigate DENV transmission. 相似文献
80.
The significance of beta-3 adrenergic receptor polymorphism in excessive body gain and obesity development in pregnant women 总被引:1,自引:0,他引:1
Seremak-Mrozikiewicz A Drews K Nowocień G Kaluba-Skotarczak A Boć A 《Ginekologia polska》2008,79(1):51-55
The current knowledge allows for the definition of the genetic factors contributing to pathological body mass gain and obesity development. One of the possible candidates is the gene of beta3-adrenergic receptor (ADRB3). Due to the fact that the basic function of this receptor is the induction of thermogenesis process and an increase of energy expenditure, the significance of Trp64Arg polymorphism of ADRB3 gene in disturbances of metabolic processes, which may induce disturbances of adipocytes function and lead to excessive body mass gain, obesity and early beginning of diseases connected with obesity (dyslipidemia, obesity, chronic hypertension, diabetes mellitus type II), has been suggested. The investigations performed in pregnant women concern, in the majority of cases, women with obesity, diabetes mellitus and gestational hypertension. These studies indicate the possible correlation of higher value of body mass index (BMI) with the presence of mutated 64Arg allele. In healthy pregnant women the relationship between Trp64Arg polymorphism of ADRB3 receptor and body gain has been suggested. Additionally, in female carries of the mutated 64Arg allele, a higher placenta mass and birth mass of newborns have been noted. This publication is merely single voice in the discussion because only one cause of excessive body gain and obesity presented here - Trp64Arg polymorphism of ADRB3 receptor. The problem seems to be more complicated and requires an investigation of the influence of other genetic and environmental factors, and the future populate investigations in Trp64Arg polymorphism of ADRB3 receptor. 相似文献