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排序方式: 共有8433条查询结果,搜索用时 15 毫秒
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Autism Spectrum Disorders (ASDs) and Attention Deficit and Hyperactivity Disorder (ADHD) are the most common comorbid conditions associated with childhood epilepsy. The co-occurrence of an epilepsy/autism phenotype or an epilepsy/ADHD phenotype has a complex and heterogeneous pathogenesis, resulting from several altered neurobiological mechanisms involved in early brain development, and influencing synaptic plasticity, neurotransmission and functional connectivity. Rare clinically relevant chromosomal aberrations, in addition to environmental factors, may confer an increased risk for ASDs/ADHD comorbid with epilepsy. The majority of the candidate genes are involved in synaptic formation/remodeling/maintenance (NRX1, CNTN4, DCLK2, CNTNAP2, TRIM32, ASTN2, CTNTN5, SYN1), neurotransmission (SYNGAP1, GABRG1, CHRNA7), or DNA methylation/chromatin remodeling (MBD5). Two genetic disorders, such as Tuberous sclerosis and Fragile X syndrome may serve as models for understanding the common pathogenic pathways leading to ASDs and ADHD comorbidities in children with epilepsy, offering the potential for new biologically focused treatment options. 相似文献
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Characterization of four Latin American families confirms previous findings and reveals novel features of acid‐labile subunit deficiency 下载免费PDF全文
Paula A. Scaglia Ana C. Keselman Débora Braslavsky Lucía C. Martucci Liliana M. Karabatas Sabina Domené Mariana L. Gutiérrez María G. Ballerini María G. Ropelato Angela Spinola‐Castro Adriana A. Siviero‐Miachon Juliana Saito Tartuci María Sol Rodríguez Azrak Rodolfo A. Rey Héctor G. Jasper Ignacio Bergadá Horacio M. Domené 《Clinical endocrinology》2017,87(3):300-311
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Isabel Adler Andrea Muio Silvia Aguas Laura Harada Mariana Diaz Adriana Lence Mario Labbrozzi Juan Manuel Muio Boris Elsner Alejandra Avagnina Valeria Denninghoff 《World journal of gastroenterology : WJG》2014,20(29):9922-9935
Helicobacter pylori(H.pylori)has been found in the oral cavity and stomach,and its infection is one of the most frequent worldwide.We reviewed the literature and conducted a Topic Highlight,which identified studies reporting an association between H.pylori-infection in the oral cavity and H.pylori-positive stomach bacterium.This work was designed to determine whether H.pylori is the etiologic agent in periodontal disease,recurrent aphthous stomatitis(RAS),squamous cell carcinoma,burning and halitosis.Record selection focused on the highest quality studies and meta-analyses.We selected 48 articles reporting on the association between saliva and plaque and H.pylori-infection.In order to assess periodontal disease data,we included 12 clinical trials and 1 meta-analysis.We evaluated 13 published articles that addressed the potential association with RAS,and 6 with squamous cell carcinoma.Fourteen publications focused on our questions on burning and halitosis.There is a close relation between H.pylori infection in the oral cavity and the stomach.The mouth is the first extra-gastric reservoir.Regarding the role of H.pylori in the etiology of squamous cell carcinoma,no evidence is still available. 相似文献
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Adriana Benavides-Lara María de la Paz Barboza-Arguello Mauricio Gonzlez-Elizondo Marcela Hernndez-deMezerville Helena Brenes-Chacn Melissa Ramírez-Rojas Catalina Ramírez-Hernndez Nereida Arjona-Ortegn Shana Godfred-Cato Diana Valencia Cynthia A. Moore Alejandra Soriano-Fallas 《Emerging infectious diseases》2021,27(2):360
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