全文获取类型
收费全文 | 7156篇 |
免费 | 370篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 85篇 |
儿科学 | 149篇 |
妇产科学 | 170篇 |
基础医学 | 919篇 |
口腔科学 | 508篇 |
临床医学 | 510篇 |
内科学 | 1614篇 |
皮肤病学 | 130篇 |
神经病学 | 455篇 |
特种医学 | 150篇 |
外科学 | 1057篇 |
综合类 | 28篇 |
一般理论 | 1篇 |
预防医学 | 913篇 |
眼科学 | 108篇 |
药学 | 408篇 |
中国医学 | 56篇 |
肿瘤学 | 294篇 |
出版年
2023年 | 49篇 |
2022年 | 145篇 |
2021年 | 243篇 |
2020年 | 133篇 |
2019年 | 201篇 |
2018年 | 244篇 |
2017年 | 177篇 |
2016年 | 157篇 |
2015年 | 209篇 |
2014年 | 320篇 |
2013年 | 309篇 |
2012年 | 457篇 |
2011年 | 578篇 |
2010年 | 297篇 |
2009年 | 241篇 |
2008年 | 392篇 |
2007年 | 418篇 |
2006年 | 373篇 |
2005年 | 349篇 |
2004年 | 342篇 |
2003年 | 237篇 |
2002年 | 214篇 |
2001年 | 166篇 |
2000年 | 172篇 |
1999年 | 134篇 |
1998年 | 43篇 |
1997年 | 28篇 |
1996年 | 33篇 |
1995年 | 40篇 |
1994年 | 23篇 |
1993年 | 30篇 |
1992年 | 82篇 |
1991年 | 62篇 |
1990年 | 61篇 |
1989年 | 43篇 |
1988年 | 57篇 |
1987年 | 54篇 |
1986年 | 49篇 |
1985年 | 39篇 |
1984年 | 24篇 |
1983年 | 28篇 |
1982年 | 21篇 |
1981年 | 23篇 |
1980年 | 25篇 |
1979年 | 26篇 |
1978年 | 21篇 |
1975年 | 19篇 |
1973年 | 16篇 |
1968年 | 17篇 |
1967年 | 18篇 |
排序方式: 共有7555条查询结果,搜索用时 0 毫秒
91.
Gabrielle R. Sena Tiago P. F. Lima Suely A. Vidal Maria do Carmo M. B. Duarte Patrícia G. M. Bezerra Eduardo J. Fonseca Lima Cynthia Braga Lívia B. de Andrade Mecneide M. Lins Leuridan C. Torres Jurema T. O. Lima Maria Julia G. Mello 《The American journal of tropical medicine and hygiene》2021,104(4):1507
92.
Rogério Tavares Ribeiro Rita Andrade Dulce Nascimento do Ó Ana Filipa Lopes João Filipe Raposo 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2021,31(4):1267-1275
Background and aimsBlinded retrospective continuous glucose monitoring (rCGM) provides detailed information about real-life glycaemic profile. In persons with type 2 diabetes without adequate glycaemic control, the structured introduction of rCGM may be beneficial to sustain improvements in diabetes management.Methods and results102 individuals with insulin-treated type 2 diabetes, age less than 66 years old and HbA1c >7.5%, were recruited. Participants performed a 7-day blinded rCGM (iPro2) every four months for one year. Biochemical, anthropometric, and rCGM data was collected. Participants' and healthcare professionals’ perceptions were assessed.90 participants completed the protocol. HbA1c was 9.1 ± 0.1% one year prior to enrolment and 9.4 ± 0.1% at enrolment (p < 0.01). With the rCGM-based intervention, a decrease in HbA1c was achieved at 4 months (8.4 ± 0.1%, p < 0.0001), and 12 months (8.1 ± 0.1%, p < 0.0001). A significant increase in time-in-range was observed (50.8 ± 2.4 at baseline vs 61.5 ± 2.2% at 12 months, for 70–180 mg/dL, p < 0.001), with no difference in exposure time to hypoglycaemia. After 12 months, there was an increase in self-reported diabetes treatment satisfaction (p < 0.05).ConclusionIn persons with type 2 diabetes and poor metabolic control, specific data from blinded rCGM informed therapeutic changes and referral to targeted education consultations on nutrition and insulin administration technique. Therapeutic changes were made more frequently and targeted to changes in medication dose, timing, and/or type, as well as to lifestyle. Together, these brought significant improvements in clinical outcomes, effective shared decision-making, and satisfaction with treatment.Registration numberNCT04141111. 相似文献
93.
Drio C. Sobral Filho Pedro L. do Rêgo Aquino Guilherme de Souza Silva Caroline B. Fabro 《Current Cardiology Reviews》2021,17(2):209
Left ventricular noncompaction (LVNC) is a congenital pathology that directly affects the lining walls of myocardial tissue, causing trabeculations with blood filling in the inner wall of the heart, concomitantly with the development of a mesocardial thinning. Although LVNC was described for the first time as long ago as 1984, our understanding of the disease with regard to its genetic pattern, diagnosis, clinical presentation and treatment is still scanty. LVNC can present as an isolated condition or associated with congenital heart disease, genetic syndromes or neuromuscular disease. This suggests that LVNC is not a distinct form of cardiomyopathy, but rather a morphological expression of different diseases. Recognition of the disease is of fundamental importance because its clinical manifestations are variable, ranging from the absence of any symptom to congestive heart failure, lethal arrhythmias and thromboembolic events. The study of this disease has emphasized its genetic aspects, as it may be of sporadic origin or hereditary, in which case it most commonly has an autosomal dominant inheritance or one linked to the X chromosome. Echocardiography is the gold standard for diagnosis, and magnetic resonance imaging may refine the identification of the disease, especially in those patients with non-conclusive echocardiography. This article sets out to review the main characteristics of LVNC and present updates, especially in the genetic pattern, diagnosis and treatment of the disease. 相似文献
94.
95.
Ibon Jaunarena Ruben Ruiz Mikel Gorostidi Paloma Cobas Marisa Avila David Del Valle Juan Cespedes Arantza Lekuona 《Journal of minimally invasive gynecology》2019,26(5):954-959
Study ObjectiveTo assess the efficacy of Tissucol Duo (Baxter AG, Vienna, Austria) fibrin sealant in decreasing the incidence of lymphocele (LC) after pelvic laparoscopic lymph node dissection using harmonic shears.DesignRandomized controlled trial (Canadian Task Force classification level I).SettingTertiary referral and educational center.PatientsSeventy-four patients randomized to the use of sealant per hemipelvis.InterventionFibrin sealant.Measurements and Main ResultsAfter bilateral pelvic lymphadenectomy a fibrin sealant was used in 1 hemipelvis but not the other, applied in 41 patients (55.4%) to the left and 33 patients (44.6%) to the right hemipelvis. The primary outcome was the incidence of LC after surgery in symptomatic and asymptomatic patients. Imaging (ultrasound, computed tomography, and magnetic resonance) was performed to detect LC at 3, 6, and 12 months after surgery. Overall, 26 patients (35.1%) developed LC, and 4 were symptomatic (5.4%). Allowing patients to serve as their own treatment group and control, the hemipelvis treated with Tissucol Duo corresponding to the treatment group and that not treated to the control group, LCs were found in 17 (23%) and 14 (19%) cases, respectively, but the difference was not significant. The mean initial LC maximum diameter was 27.1 mm (standard deviaiotn, 35.2), and LCs tended to decrease in size during the first year to a mean of 8.7 mm.ConclusionApplication of Tissucol Duo fibrin sealant after laparoscopic pelvic lymphadenectomy using ultrasonic shears does not decrease the occurrence of symptomatic or asymptomatic LC. 相似文献
96.
F.E. Fernández Suárez R. del Valle Fernández A. González Alvarez J. Sánchez Lasheras L. Fernández Sánchez L. Argüelles Tamargo 《Revista espa?ola de anestesiología y reanimación》2013,60(8):440-447
ObjectiveTo analyze the experience and anesthetic management in the transcatheter implantation of the CoreValve® self-expanding aortic valve, in a university tertiary hospital.Material and methodsObservational analytical review of data incorporated into a prospectively maintained database of 142 patients diagnosed with severe aortic stenosis who underwent implantation of a CoreValve® aortic self-expanding aortic valve between December 2007 and December 2012.ResultsThe mean age of patients was 82.5 ± 6.1 years and the logistic EuroSCORE was 14.9 ± 11.2. General anesthesia was used in 107 patients (75.3%), with local anesthesia with sedation in 35 (24.6%). Local anesthesia and sedation was associated with a lower requirement of vasoactive drugs (P = .003) during implantation. No statistically significant differences were found between the 2 anesthetic techniques in the duration of the procedure, hospital stay, or morbimortality. The success rate was 97.1%. The most common complication was conduction disorders that required implantation of a permanent pacemaker in 46 patients (32.3%). There was no intraoperative mortality, and all-cause mortality at 30 days was 6.3%, with a one-year survival estimated by the Kaplan-Meier of 83.1%.ConclusionsThis study confirms that in patients with severe aortic stenosis and high surgical risk, transcatheter implantation of aortic valve is a safe and effective alternative. Both, general anesthesia and local anesthesia with sedation are valid options, depending on the experience of the team. 相似文献
97.
Bernard Salame Gemaque Alex Junior Souza de Souza Manoel do Carmo Pereira Soares Andreza Pinheiro Malheiros Andrea Lima Silva Max Moreira Alves Michele Soares Gomes-Gouvêa Jo?o Renato Rebello Pinho Heriberto Ferreira de Figueiredo Djacy Barbosa Ribeiro Jonan Souza da Silva Leopoldo Augusto Moraes Ana Silvia Sardinha Ribeiro Washington Luiz Assun??o Pereira 《Emerging infectious diseases》2014,20(12):2180-2182
98.
Joaquín Valle Alonso Motiur Chowdhury Raju Borakati Upali Gankande 《The American journal of emergency medicine》2017,35(12):1986.e3-1986.e4
Swimming Induced Pulmonary Edema, or SIPE, is an emerging condition occurring in otherwise healthy individuals during surface swimming or diving that is characterized by cough, dyspnea, hemoptysis, and hypoxemia. It is typically found in those who spend time in cold water exercise with heavy swimming and surface swimming, such as civilian training for iron Man, triathalon, and military training. We report the case of a highly trained young female swimmer in excellent cardiopulmonary health, who developed acute alveolar pulmonary oedema in an open water swimming training diagnosed in the emergency department using POCUS ultrasound. 相似文献
99.
Bisi Melissa Cláudia do Prado Aline Defaveri Piovesan Deise Marcela Bredemeier Markus da Silveira Inês Guimarães Mendonça José Alexandre Staub Henrique Luiz 《Clinical rheumatology》2018,37(3):855-855
Clinical Rheumatology - The original version of this article, unfortunately, contained an error. One of the author's name on this article was incorrectly spelled as “José Alexandre... 相似文献
100.
Ewelyne M. de Lima Andrews M. do Nascimento Girlandia A. Brasil Placielle F. Filete Ieda C. Kalil Dominik Lenz Denise C. Endringer Nazaré S. Bissoli Tadeu U. de Andrade 《Fundamental & clinical pharmacology》2016,30(4):316-326
This study evaluated the effects of the isolated use of a low dose of methyltestosterone (MT) on cardiovascular reflexes and hormonal levels and its geno‐ and cytotoxic safety in ovariectomized rats. Female Wistar rats were divided into four groups (n = 6), respectively: SHAM (received vehicle methylcellulose 0.5%), SHAM + MT (received MT 0.05 mg/kg), OVX (received vehicle), and OVX + MT (received MT). Twenty‐one days after ovariectomy, treatment was given orally daily for 28 days. The Bezold–Jarisch reflex (BJR) was analyzed by measuring the bradycardic and hypotensive responses elicited by phenylbiguanide (PBG) administration. The baroreflex sensitivity (BRS) was evaluated by phenylephrine and sodium nitroprussite. Myocyte hypertrophy was determined by morphometric analysis of H&E stained slides. Biochemical data were analyzed, as well as micronucleus assay. MT improved BRS and increased testosterone values, but did not change estradiol in the OVX group. MT did not promote changes in mean arterial pressure, heart rate, BJR, serum concentrations of troponin I, weight and histopathology of the heart. MT was able to restore the BRS in OVX rats. The geno‐ and cytotoxic safety of the MT was demonstrated by the absence of an increase in the micronucleus (PCEMN) or change in the ratio between normochromatic erythrocytes and polychromatic erythrocytes (NCE/PCE). 相似文献