The effect of cardiovascular morbidity on clinical response provided by tadalafil in patients with erectile dysfunction

We aimed to investigate the association between erectile dysfunction and severity of cardiovascular morbidity and to assess clinical responses to tadalafil of patients in different cardiovascular risk groups. Between November 2019 and August 2020, a total of 258 male patients aged 45–70 years with ED were included. They were divided into three groups according to the Framingham risk score: low-risk (n: 86, 33.3%), intermediate-risk (n: 103, 39.9%) and high-risk (n: 69, 26.8%). At admission, all domains of the International Index of Erectile Function score were worse in high-risk group compared to other risk groups (p < .001). After a 12-week follow-up, a more significant improvement was observed in all domains of erectile function in all risk groups, but high-risk group had lower sexual scores (p < .001). The lowest rate for complete responsiveness to tadalafil was observed in the high-risk group (37.7%). The rate of failure in complete responsiveness was found to be 4.127 times greater with higher Framingham score and 3.102 times greater with higher erectile dysfunction severity at admission. Our preliminary findings show that more severe sexual disorders are observed in high-risk patients with cardiovascular morbidity. Individualised treatment may be important in high-risk group since they may benefit less from tadalafil, and failure in complete responsiveness can be more common in this group.     

Microsurgical versus endoscopic trans-sphenoidal approaches for clivus chordoma: a pooled and meta-analysis

Neurosurgical Review - Chordoma is a rare slow-growing neoplastic bone lesion. However, they show an invasive local growth and high recurrence rate, leading to an overall survival rate of 65% at 5...     

化痰祛瘀法治疗肝豆状核变性研究进展

肝豆状核变性(WD)在西医学上是铜代谢障碍导致全身多器官损害等为主要临床特征的常染色体隐性单基因遗传疾病,病变影响肝、脑、肾、角膜等重要脏器。中医通过对WD患者临床症状及病理改变的认识,认为WD的基本病理因素为痰浊、瘀血,二者相互作用而发病,以痰瘀互结为主要的病机,贯穿疾病发展始终,故而运用化痰祛瘀法治疗WD在临床中常见。众多研究表明运用中药汤剂、中医外治法化痰祛瘀治疗可以有效缓解WD患者临床症状,发挥排铜优势、改善肝纤维化、改善脑流动力学、抑制炎症和抗氧化应激作用,进而延缓疾病进程,控制疾病发展。现结合新近研究成果,对化痰祛瘀法在WD的临床应用予以综述,以期为临床治疗WD提供中西医结合治疗有效的方案及依据。     

Synthesis of sulphonic acids and sultam derivatives

Reaction of propane-1,3-sultone with amines gave N-substituted aminosulphonic acids2a?i. Dehydration of2a?c with POCl₃ gave the corresponding sultams3a?c. Propane-1,3-sultone1 reacted with tertury amines to give the betaiene salts4–11. 2,4-Dimethyl-1,3-butadiene-1,4-sultone12 condensed with amines to give N-substituted-2,4-dimethyl-1,3-butadiene-1,4-sultams13a and13b. The reaction of3a, 13a with hydrazine hydrate gave acid hydrazides3d or13c. Compounds3d, 13c reacted with isocyanates to yield urea derivatives14a?c, 15a?c.     

计算机辅助的心血管信号检测和处理系统的研究

【目的】研制一个计算机辅助的心血管信号检测和处理系统。【方法】本系统的硬件设计采用奔腾 Ⅱ / 2 33多媒体微机系统 ,多路模 /数转换器和心电电极、心音传感器、脉搏波传感器及由运算放大器等构成相关的放大器及滤波器。本系统采用可视化编程环境构建系统结构和功能模块设计的方法 ,基于多媒体技术和小波变换原理 ,在 32位Windows平台下 ,利用可视化编程语言VisualC 6 0和多媒体著作工具Authorware等进行系统的软件设计。【结果】本系统能完成心电、心音、脉搏波信号检测和处理 ,并将结果以图、文、声并茂的形式显示、打印或播放 ,还具有病案管理和心音听诊多媒体计算机辅助教学功能。【结论】它是一个新型的多功能心血管信号检测和处理系统。     

100例重庆市汉族儿童哮喘α1-抗糜蛋白酶基因突变初探

目的：了解儿童哮喘α１－抗糜蛋白酶（α１－ａｎｔｒｉｃｈｙｍｏｔｒｙｐｓｉｎ,α１－ＡＣＴ）基因点突变情况。方法：应用聚合酶链反应（ＰＣＲ）和限制性酶切图谱分析技术,对１００全重庆市汉族儿童哮喘α１－ＡＣＴ基因外显子（ｅｘｏｎ）Ⅱ和Ⅲ进行检测。结果：所有研究对象均未发现Ｂｏｎｎ－１及Ｂｏｃｈｕｍ－１变异体。结论：Ｂｏｎｎ－１和Ｂｏｃｈｕｍ－１变异体与１００全重庆市汉族儿童哮喘发病无平行关系。     

甲硝唑磷酸酯钾的家兔药物动力学研究

:目的 :研究甲硝唑磷酸酯钾 (PMP)及甲硝唑 ((MTZ)在家兔血中的药物动力学参数。方法 :家兔iv和im等量的PMP、MTZ(10 0 μmol/kg)后 ,用HPLC苦味酸内标法测定家兔血浆中PMP和MTZ的浓度。 结果 :家兔iv等量PMP和MTZ后 ,其家兔血中PMP和MTZ药 -时曲线均符合二室开放模型 ,但其PMP释出的MTZ药 -时曲线较MTZ的药 -时曲线稍低 ,前者的AUC为后者的 47 4%。家兔im等量PMP和MTZ后 ,PMP释出的MTZ药 -时曲线为一室模型 ,MTZ的药 -时曲线为二室模型。前者的Cmax较后者低 ,其AUC为后者的38 9%。结论 :家兔ivPMP和MTZ后 ,二者末端的消除速率接近 ;家兔imPMP和MTZ后 ,二者的Tp 相近。     

丝光绿蝇饲养初步研究

目的通过对丝光绿蝇的室内饲养,观察其驯化以及饲养的生物学。方法采用煮熟的鲢鱼引诱丝光绿蝇产卵,收集其卵块,置于室内采用人工配制饲料进行驯化饲养。结果丝光绿蝇第１代从卵发育至成蝇需１４天,其中三龄期约５天,蛹期约６天。成蝇产卵前期约７天,卵散产。第２代从卵发育至成蝇约需１３天,其中三龄期约４天,蛹期约６天。结论丝光绿蝇室内驯养在温度２６℃～３１℃,相对湿度７５％条件下,从卵到蝇历期为１３～１４天,驯养初期,其生物学与自然条件下相比有所改变。     

Anthropometric measurements and body composition of selected national athletes

This study was conducted to determine the anthropometric measurements and body composition of selected national athletes. A total of 84 male athletes from 10 different types of sports and 24 female athletes from 5 types of sports were studied. The height and body weight of subjects were measured using the SEGA weighing balance with height attachment. Skinfold thickness measurements were taken using the Harpenden Calipers at 4 sites (biceps, triceps, subscapular and suprailiac). Percentage of body fat was calculated from the sum of 4 measurements of skinfold thickness. Based on body mass index (BMI), most of the male (68 subjects or 81%) and female (19 subjects or 79%) athletes were classified as normal. The percentage average body fat for both male and female athletes were 13.8 ± 4.5% and 24.7 ± 5.3%, respectively. The male and female athletes also had lower percentage of body fat when compared to non-athletes, however these athletes had slightly higher percentage of body fat when compared to those in selected countries.