无痛胃镜检查的配合及护理

目的对于无痛胃镜检查的临床效果进行探讨。方法将100例患者随机分为两组,一组在进行胃镜检查前注射丙泊酚并做出相应护理,一组则不作配合护理,然后对两组患者在检查过程中的血压、心率、检查反应以及血氧饱和度等变化进行观察比较。结果使用静脉注射丙泊酚的一组患者的镇静作用良好,不良反应较低,血压、心率没有明显变化,另一组患者则有明显的血压升高、心率加快表现。结论无痛胃镜与有效护理能明显提高患者对检查的耐受性,使患者得到较好的、痛楚较小的检查。     

主动脉夹层18例误诊分析

目的 分析主动脉夹层的误诊情况以提高对该病的认识。方法 选取3l例主动脉夹层中18例误诊病例的相关资料，对临床表现、确诊方法及误诊情况进行回顾性分析。结果 误诊疾病为急性脑血管病、急性心梗、大动脉炎、急腹症、急性肾衰、下肢动脉栓塞、急性胰腺炎、肾性高血压等．总误诊率58％。结论 主动脉夹层病情复杂、进展迅速、误诊率高、预后差。临床医生，特别是非心血管医生应提高对此病的认识，以期早诊断、早治疗。     

一种治疗翼状胬肉的新术式

翼状胬肉治疗方法很多,却很难有效控制其复发。笔者采用彻底切除翼状胬肉根部的方法,治疗146例,经长期随访观察,效果满意。报告如下。对象与方法1.对象:本文以门诊及住院的翼状胬肉患者134人(146眼)为治疗观察对象。男93人,女41人。年龄18—74岁。双眼发病12     

人参总皂苷对大鼠脑外伤后神经细胞凋亡的影响

目的 研究人参总皂苷对脑外伤大鼠神经细胞凋亡的影响,探讨其抑制创伤性脑损伤(TBI)后继发性损伤的作用机制.方法 采用改良的Feeney自由落体法建立脑外伤模型,将Sprague-Dawley大鼠54只按照随机数字表法分为假手术组、脑外伤组、人参总皂苷治疗组(治疗组),每组18只.模型建立后24h处死大鼠,采用干湿重法测量脑水含量,光镜下观察尼氏染色海马细胞形态,凋亡细胞原位末端标记法(TUNEL)和免疫组织化学方法观察大脑皮质、海马神经细胞凋亡及凋亡基因bax、bcl-2、caspase-3的蛋白表达情况.结果 与脑外伤组比较,人参总皂苷治疗后的治疗组脑含水量明显减低,损伤侧海马病理学改变明显减轻,神经细胞凋亡减少,bcl-2的表达增高,bax、caspase-3的表达减少,差异均有统计学意义(P＜0.05).结论 人参总皂苷可以减轻脑外伤后继发性损伤,其机制可能是升高bcl-2的表达,抑制bax、caspase-3的表达,从而阻滞TBI后神经细胞凋亡.     

HMBA在肿瘤诱导分化治疗中的研究进展

HMBA(hexamethylene bisacetamide,环六亚甲基双乙酰胺)是一种小相对分子质量的平面极性化合物,对红白血病、神经母细胞瘤、胃癌等多种肿瘤细胞具有明显的诱导分化作用,是已经试用于临床的少数分化诱导剂之一.随着对肿瘤诱导分化研究的逐步深入、寻求诱导分化药物的需求与日俱增,近年来发现了许多具有临床价值的、诱导肿瘤细胞分化的新药,关于HMBA在肿瘤诱导分化治疗中的研究也取得一定的进展.     

脂氧素A4对心肌缺血再灌注损伤的保护作用

Objective To investigate the roles of lipoxin A4, an endegenous lipid mediator with wide anti-inflammatory fea- tures, in attenuating myocardial ischemia-reperfusion injury and the possible mechanisms. Methods Thirty male KM mice were divid- ed randomly into three groups, 10 in each: ischemia-reperfusion group (group A), lipoxin A4 (0.1 mg/kg) group (group B) and Zn- PP (Zinc protoporphyrin Ⅸ, 25 mg/kg)phus lipoxin A4 (0.1 mg/kg)group (group C). A ischemia-reperfusion heart model was de- veloped by ligating the lift anterior descending branch of the coronary artery. A dine of 10% dehydrated alcohol in 0.2 ml for group A, a dose of isochoric lipoxin A4 for group B and a dose of isochoric ZnPP + lipoxin A4 for group C was infused into the ascending aorta through a catheter, which was kpassing the right common carotid artery, 30 minutes after reperfusion. The concentration of serum TNF-α, activities of serum crestine kinase(CK) and lactate dehydrogenase (LDH), activities of myeloperoxidase (MPO) and malond- ialdehyde (MDA) and the cell apoptosis rate in the myocardial tissue were measured 5 hours after reperfusion. Pathological features of the inflammatory infiltration in the myocardium were also observated.Results As compared with group A, the inflammatoryry infiltra- tion in the ischemic and necrotic regions tithe myocardium was reduced, with group C in the intermediate range. The serum activities of CK and LDH wine significantly lower in group B and C than that in group A, and the lowest activities were detected in group B. Similar findings were observed for MPO, an indicator for neutrophil infiltration, and MDA, an indictor for cell injury caused by oxy- gen radicals, in the myocardium. The concentration of TNF-α and the rate of cadiocyte apoptosis were decreased significantly in group B(P < 0.01). ZnPP, an inhibitor of heine oxygenase (HO)-1, attenusted the above protective effects of lipoxin A4 significantly (P<0.05). Conclusion Lipoxin A4 has protective effects against myocardial ischemia-reperfusion injury, and HO-1 may have a potential role in the protectve mechanisms of lipoxin A4, probably pertly by means of reducing the production of reactive oxygen spe- cies and TNF-α, decreasing the activation and infiltration of neutrophils, alleviating inflammatory damage and avoiding apoptosis.     

193 nm氟化氩激光应用于屈光性角膜切削的精确性及预测性

1975年有学者发现了准分子激光并将它应用于角膜屈光性手术,使屈光手术有了重大突破,成为现代眼科学中发展最快的领域之一。波长为193 nm的氟化氩激光可以使角膜组织分子气化,故准确度非常高,而且对于被照射部位旁边的组织不产生热效应,对角膜的构造不会产生不良的效应。目前准分子激光已成功应用于角膜放射状切开术、准分子激光屈光角膜切削术、准分子激光原位角膜磨镶术、准分子激光角膜上皮瓣下磨镶术及机械法准分子上皮下角膜磨镶术等。随着对准分子激光认识的不断深入,以及临床经验的不断积累,新的、精确度高的、预测性好的准分子激光屈光性角膜手术方式将不断涌现。     

高兴就好

半夜十二点到家,掏出钥匙正要开门,身后有动静.回身一看,是对门张大哥. 张大哥四十多岁,土建工程师,黑胖,秃顶.     

针刺治疗癔病、焦虑症50例临床分析

本文报道了采用针刺疗法,治疗急诊科临床常见的癔病、焦虑症,见于昏厥型、狂躁型和症状转换型患者共50例,均收到了良好的效果,前两型可于当天治愈,后一型最少2天,最多4天治愈。