肝癌肝动脉药物灌注加栓塞治疗引发胆囊炎的探讨

对67例肝癌肝动脉药物灌注加栓塞治疗引发胆囊炎的机理进行了探讨,认为主要原因是影响了胆囊的血供,为避免此并发症,提出了超选择插管及使用血管收缩剂的建议。     

左眼睑骨性迷离瘤一例

患者男性,56岁,自诉左上眼睑肿物10余年,于2007年4月6日收入佳木斯大学附属第一医院眼科.患者于10余年前曾被砂轮崩伤左眼,当时具体治疗情况不详,其后发现左上眼睑出现肿物,无红、肿、热、痛等伴随症状.近2年来,肿物呈渐进性增大.患者既往身体健康,无遗传病、传染病、流行性疾病史.入院查体:体温36.2℃,血压:120/80 mm Hg(1 mm Hg=0.133 kPa).     

延生护心液药理作用及临床观察

延生护心波为沈阳飞龙保健品有限公司推出的保健新药，具有益气活血，养心安神之功效。用于胸痹、胸痛、胸闷、心悸、气短、喘息等症的预防和辅助治疗。1药理作用1．1抗缺氧作用：给小鼠灌胃给予延生护心波7·2、ZI·6g／kg·d，连续川，能显著延长小鼠耐缺氧的存活时间，存活时间（min）分别为43．21士9．42，63·10土15·34；而生理盐水织小鼠存活时间为35·36土6·99（P＜0．of，P＜0．001）。对异丙肾上腺素引起的心脏耗氧量增加的小鼠，其抗缺氧作用尤强，均能明显延长小鼠存活时间（P＜0．of），分别延长80％和136·8％；复方丹参片…     

头孢哌酮钠-舒巴坦钠致血小板减少

1 病例资料 男,52岁.主因车祸致腰部损伤3小时入院.诊断:膀胱直肠瘘;急性肾功能衰竭;消化道损伤;肝功能不全;双肺感染;心功能不全.查血白细胞17.41×109/L,红细胞4.13×1012/L,中性粒细胞0.73,淋巴细胞0.25,血小板237×109/L,血红蛋白133 g/L,血肌酐385μmol/L,尿素20.40 mmol/L,尿酸663μmol/L.予依诺沙星、头孢噻吩及甲硝唑抗感染治疗,入院后第7天改用注射用头孢哌酮钠-舒巴坦钠3g静脉滴注,每天2次.     

自发性肾破裂致结石移位一例

[病例]女,41岁.主因左腰部疼痛10余天入院.10天前无诱因出现左腰腹部疼痛,呈持续性隐痛,无放射痛、发热、尿频、尿急、尿痛、肉眼血尿等,恶心,未呕吐.查体:生命体征平稳,心肺腹(-).双肾区无隆起,无红肿,左肾区叩击痛( ),双侧输尿管行径区无触压痛.血白细胞12.3×109/L,红细胞4.0×1012/L,血红蛋白135 g/L.尿常规未见异常.血尿素5.02 mmol/L,肌酐78.0μmol/L,尿酸267.0μmol/L.     

卡马西平致大疱性表皮松解型药疹

[病例]女,40岁.因偏头痛3个月就诊于我院神经内科,确诊为三叉神经痛.给予卡马西平片(江苏鹏鹞药业有限公司生产,批号0410191)0.1g,口服,每日3次.服药第3天面部及周身皮肤出现片状红色斑疹,未停药,次日自感嗜睡、恶心、腹痛,呕吐、腹泻数次,红色斑疹融合,斑疹表面形成数厘米的不规则大疱,疱壁松弛起皱,伴瘙痒,自行停药.遂收入皮肤科治疗.     

胆囊结石的中药治疗体会

胆囊结石的中西医结合非手术治疗始于上世纪五十年代的排石疗法，最初采用针刺和利胆通等中药促进排石。后来发展到中西医药结合的总攻排石，使排石率有了提高，但与胆管结石的排石率相比，排净率依然很低，胆囊结石排石治疗适应证应是：(1)胆囊病变损害轻，收缩功能良好。(2)胆囊管以及胆总管下端无明显器质性狭窄。(3)肝功无明显异常。(4)结石直径应在1cm以下。     

环境条件对磁螺菌生长的影响

目的了解碳源种类及浓度、氧、还原剂等条件对磁螺菌（Magnetospirillum gryphiswaldense）生长的影响；建立深层培养磁螺菌及磁小体的技术。方法在60ml血清瓶中，将供试菌株在不同种类和浓度的碳源培养基，不同氧浓度等条件下培养，测定OD600nm；在5L自动控制发酵罐（L．E．Marubishi Co．Tokyo，Japan）中，控制pH、温度及转速分别为7．2、30℃、400r／min，通气量为1．0L／min-1．2L／min，氧浓度为0．5％-0．7％的条件下，以乙酸钠-苹果酸培养基和乳酸钠培养基深层培养供试菌株，测定OD60nm.用高效液相色谱等分析培养过程中碳氮源变化规律；用电子显微镜观察磁小体的合成。结果碳源的种类及浓度是影响该菌生长和磁小体合成的重要因素之一；在乙酸钠一苹果酸培养基和乳酸钠培养基中深层培养25h的细胞密度分别为0．7和1．7OD600nm.结论乳酸钠培养基是适合于磁螺菌快速生长的最佳培养基。建立了深层培养磁螺菌及磁小体的技术和方法，该方法的建立对于大量获得细菌磁小体而进行应用开发具有重要意义。     

雷帕霉素纳米粒滴眼液联合环孢素A缓释膜治疗兔高危角膜移植术后免疫排斥反应的研究

Objective To evaluate the combined effect of topical rapamycin (RAPA) eye drop in nanometer vector and poly (lactic acid) (PLA) wafers of cyclospoirne A(CsA) in the prevention of acute allograft rejection after rabbit corneal transplantation. Methods It was an experimental study. RAPA was incorporated into the nanometer particles and CsA was incorporated into PLA wafers. A was syngeneic control whose both donor and recipient are New Zealand rabbit. Gray donor corneas were implanted into the 102 recipients of New Zealand albino rabbits with corneal neovascularization who were randomly divided into B, C, D, E, F, G 6 groups to receive the different types of therapy: B was no therapy control; C was eye drop of nanometer vector but no RAPA twice a day,28 days; D was PLA wafers in the anterior chamber of rabbit eyes but no drugs; E was 0.5% RAPA eye drop of nanometer vector twice a day,28 days; F was PLA wafers of CsA in the anterior chamber of rabbit eyes; G was PLA wafers of CsA in the anterior chamber of rabbit eyes and 0.5% RAPA eye drop of nanometer vector eye drop twice a day for 28 days together. Postoperative evaluation included slit-lamp biomicroscopy, histopathology and immunohistoiogy, Cytokines related with neovascularization and immunosuppression in the corneal tissue by RT-PCR. The graft survival was assessed by One-Way ANOVA and q test. Results Corneal allograft survival time: A (100.00±0.00), B ( 8.44±1.24), C (8.89±2.57), D (8.56±2.30), E (43.11±5.58), F (43.67±9.54), G (72.00±15.34)d. Group G led to a statistically significant prolongation of transplant survival and was superior than group E and F which was a statistical prolongation compared with group B, C and D (qGE=11.42, qGF=11.24,qEB=13.64, qEC=13.38, q<=13.46, qFB=13. 82, qFC=13.56, qFD=13.64; P<0.01). Immunohistopathologically, the grafts were subjected to an immune response contained a dense infiltrate of neutorphils,CD4+ and CD8+ T lymphocytes in the group B ,C and D. This cellular infiltrate was a significant reduction in group E,F,G. RT-PCR showed that the gene expression of IL-2 was inhibited earlier (3 days) in group F, G and VEGF gene expression being suppressed later (14 days) in group E, G. Conclusions Combined therapy with topical application of RAPA eye drop of nanometer vector and CsA PLA wafers can significantly prolong the survival of allograft at high-risk. Moreover, topical combined treatment of them is more effective, lower dosage, less side-effects and cheaper than the treatment with topical individual immunosuppressive drug.     

新生儿和正常青年人瞬态诱发耳声发射的频谱分析

选用短声及短音１ｋＨｚ和２ｋＨｚ作为瞬态刺激声，对１８名正常产新生儿及１８名正常青年人进行诱发耳声发射测试，并将所测得的瞬态诱发耳声发射（ＴＥＯＡＥ）波形进行频域分析。结果表明：两年龄组及三种刺激声的ＴＥＯＡＥ检出率比较差异无显著性，但新生儿组短声ＴＥＯＡＥ检出率（９１．７％）低于国外资料报道，提示生后４天内测试ＴＥＯＡＥ会影响检出率。频谱分析表明：两年龄组及三种刺激声的ＴＥＯＡＥ频谱带宽间比较差异无显著性，但ＴＥＯＡＥ的频谱峰值随刺激声的不同而不同，其频谱特征与刺激声频率间有某种依赖关系，考虑与内耳机械、调谐特性，外耳、中耳谐振等多因素相关。