中医医院内部审核的策划与实施

通过对所在中医医院ISO9001族质量管理体系实施过程中历次内部审核的总结,探索既符合中医医院实际工作又满足标准要求的内部审核模式,形成科学化的内审流程。     

2,7,12,18-四甲基-13,17-二(3-羟基丙基)卟啉的合成及其光敏化活性

由氯化高铁次卟啉经脱铁、酯化、还原合成了光敏剂２，７，１２，１８－四甲基－１３，１７－二（３－羟基丙基）卟啉，并测定其光敏活性     

视盘血管炎——关于混合型的研讨

对６０例（６３眼）视盘血管炎的临床分型进行了探讨，结果表明，除分为Ⅰ、Ⅱ两型外，尚存在混合型，当视盘睫状血管炎性病变波及中央静脉，或两个血管系统同时受炎症侵犯时，即可再现混合型的临床表现，视盘明显水肿，视网膜静脉迂张，散在渗出，出血，动脉狭细。眼底荧光血管造影可见视盘荧光早期充盈明显迟缓，后期渗漏面积〉２．０ＰＤ，视网膜循环时间延长，混合型兼有Ⅰ，Ⅱ两型的临床特征，应作为一个独立类型存在，同时观察     

江苏省肾综合征出血热单价灭活疫苗中期免疫效果观察

观察HFRS单价灭活疫苗中期免疫效果。方法：采用IFAT法及MCPENT法检测荧光抗体及中和抗体。结果：3个试区加强接种人数分别为4052、4407和6354人。加强后，Ⅰ型苗荧光抗体阳性率为72．73％，GMT为14.14；中和抗体阳性率为54．55％，GMT为6．67。D型苗荧光抗体阳性率为75.00％，GMT为11.85；中和抗体阳性率为60％，GMT为9．44。加强后1年，Ⅰ型苗年均保护率为65．52％，Ⅱ型苗则为94．24％。同期，Ⅰ型苗荧光抗体阳性率维持在40％，中和抗体维持在35．00％；Ⅱ型苗荧光抗体阳性率降至10．34％，中和抗体维持在53．85％。结论：两型疫苗均有较好的中期防病效果。     

急性缺氧对飞行员胃液排空功能的影响

为探讨急性缺氧对飞行人员胃液体排空功能的影响，在常压下吸入不同浓度氧（17％、16％、14％、12％、10．5％及9％）的低氧混合气体30min，采用B型超声波在实验前后分别测量了64名男性飞行员的胃液体排空功能。结果表明，吸入17％低氧混合气胃排空延迟，但经统计学处理无显著性差异（P＞0．05），吸入16％以下的低氧混合气后胃排空延迟，经统计学处理有显著性差异（P＜O．01），且随着缺氧程度加重，胃液体排空时间延长更加明显。提示当发生高空缺氧时，应考虑到缺氧对胃排空有抑制作用这一因素。     

急性病毒性肝炎住院患者血清学分型与流行病学分布研究

本文收集了西安市住院急性病毒性肝炎患者血清标本２９３份，用ＥＬＩＳＡ进行分型检测，并作流行病学调查。结果发现：甲肝占６５．１９％，乙肝占１０．９２％，丙肝占４．７８％，丁肝占３．７５％，戊肝占４．４４％，诊断不明者占１０．９２％。结果表明，在西安市住院的急性病毒性肝炎中，甲肝为主要类型；与以往结果比较，甲肝患者的发病年龄明显后移；除乙肝外，各型肝炎中男性均多于女性，尤以丁肝和戊肝为著；甲肝有明显的     

Outbreaks of smallpox due to variolation in China, 1962-1965

In 1985, previously unknown outbreaks of smallpox were uncovered which had occurred in Shanxi Province and Nei Monggol Autonomous Region in northern China during 1962-1965, several years after smallpox transmission was thought to have been interrupted. During field investigation, the authors learned that most of the cases were known to local health officials but had not been officially reported to national authorities. All were among persons who had been variolated or were their close contacts. Variolation is an ancient method of protection against naturally acquired smallpox that was officially proscribed in the early 1950s but was renewed in remote areas when smallpox vaccination activities were interrupted during the three-year famine of 1959-1962, following the "great leap forward" program of 1958. It was found that the variolators in Shanxi Province and Nei Monggol Autonomous Region inoculated persons with the use of powdered smallpox scabs mixed with human milk, and that they obtained fresh supplies of scabs every 6-12 months by variolating relatives and friends. The health authorities responded by capturing the variolators, confiscating their variolation material and equipment, and vaccinating the population. The last known cases occurred in 1965, and the practice of variolation is now believed to be extinct.     

脆性X综合征的遗传学诊断与产前诊断

脆性X综合征( fragile X syndrome,FraX )是一种常见的遗传性智力低下综合征,其发病率仅次于Down综合征,呈X连锁遗传,占X连锁智力低下的40%[1].1992年,Erster SH等报道其发病率男性为1/1250,女性约为1/2000;1997年,De Vries BB等报道其发病率男性为1/4000,女性为1/6000[2-3].发病率下降的原因可能是随着诊断技术的提高,减少误诊的结果.     

Deletion spanning the 5′ ends of both the COL4A5 and COL4A6 genes in a patient with Alport's syndrome and leiomyomatosis

Alport's syndrome is characterized clinically by a nonimmune glomerulopathy, often accompanied by sensorineural hearing loss and lens abnormalities, frequently due to mutations in the COL4A5 gene. The association of AS with diffuse leiomyomatosis, a benign proliferation of smooth muscle that occurs most often in the esophagus, trachea, and female genitalia, has been reported. Recently, a deletion involving both the COL4A5 and COL4A6 genes has been reported in four unrelated families. We report an additional case with Alport's syndrome associated with leiomyomatosis carrying a deletion of both COL4A5 and COL4A6 genes. A detailed characterization of the genomic region involved in the deletion event has been performed. Our results demonstrate that the deletion removed exon l of COL4A5 and exons l and 2 of COL4A6. © 1994 Wiley-Liss, Inc.