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排序方式: 共有176条查询结果,搜索用时 31 毫秒
81.
82.
Kibar Y Irkilata HC Coban H Yildirim I Dayanç M 《International urology and nephrology》2007,39(3):775-778
The approach for the intravesical suspicious lesions or stones in the preadolescent children especially in boys is still a
challenging problem. Open surgery, percutaneous suprapubic endoscopy or transurethral endoscopic approaches are the treatments
of choice in children. However, there is a group in children between the ages of 10 and 12 years, which can be named as grey
zone population; the length of the instruments is insufficient for transurethral intervention such as endoscopic stone extraction,
transurethral bladder tumor resection especially for the lesion at the posterior bladder wall in this group. The aim of this
study is to describe a new technique using laparoscopic instruments for percutaneous bladder stone and tumoral lesion and
determines the efficacy of this procedure. Satisfactory results have been obtained in patients with these pathologies. In
selected cases, operation time, urethral and mucosal damage, hospital stay, and cost can be decreased to a minimum with this
simple technique. 相似文献
83.
Murat Dayanc Yusuf Kibar Ali U. Ural Onder Onguru Oguzhan Yildiz Hasan C. Irkilata Ferit Avcu Burak C. Soner Cunay Ulku Melik Seyrek 《Stem cell reviews》2012,8(4):1245-1253
Objectives
We researched the survival of bone marrow-derived mesenchymal stem cells (MSCs) and the results of MSCs’ injected into decompensated bladders in a rabbit model.Methods
Partial bladder neck obstruction (PBNO) and subsequent decompensation of the bladder was achieved by wrapping the bladder neck with autologous rectus fascia. In the first aspect of the experiment 18 rabbits underwent MSC injection into the decompensated bladder to prove the survivability of injected MSCs. For this purpose MSCs were isolated, transfected with Green Fluorescent Protein (GFP), and injected into the detrusor layer. Once viability was assessed in the first phase, an additional 10 rabbits underwent PBNO in the second phase. Five of these animals underwent subsequent MSC injection (group 3, stem cell) and 5 did not (group 2, obstruction). Both groups were compared to 5 controls (group 1). Urodynamics were performed in all groups. After the animals were sacrificed the groups were compared via morphometric analysis, contractile response to carbachol and KCl, and muscarinic receptor type analysis.Results
On morphometric analysis, collagenous area rates were 43, 53 and 37 % in group 1, 2 and 3, respectively. There was no statistically significant difference between groups in terms of bladder weight, bladder capacity and vesical pressure. The contractile effects of KCl and muscarinic agonist carbachol were significantly higher in groups 1 and 3 than group 2. The response to carbachol was antagonized by muscarinic M1 and M3 receptor antagonist pirenzepine and abolished by muscarinic M3 receptor antagonist 4-DAMP in all groups.Conclusions
The injection of MSCs decreased the collagenous area, increased detrusor contractility. Functional M3 receptors were also expressed in MSCs-injected bladder smooth muscle as well as in control group. 相似文献84.
D'Amours G Kibar Z Mathonnet G Fetni R Tihy F Désilets V Nizard S Michaud JL Lemyre E 《Clinical genetics》2012,81(2):128-141
Despite a wide range of clinical tools, the etiology of mental retardation and multiple congenital malformations remains unknown for many patients. Array-based comparative genomic hybridization (aCGH) has proven to be a valuable tool in these cases, as its pangenomic coverage allows the identification of chromosomal aberrations that are undetectable by other genetic methods targeting specific genomic regions. Therefore, aCGH is increasingly used in clinical genetics, both in the postnatal and the prenatal settings. While the diagnostic yield in the postnatal population has been established at 10-12%, studies investigating fetuses have reported variable results. We used whole-genome aCGH to investigate fetuses presenting at least one major malformation detected on ultrasound, but for whom standard genetic analyses (including karyotype) failed to provide a diagnosis. We identified a clinically significant chromosomal aberration in 8.2% of tested fetuses (4/49), and a result of unclear clinical significance in 12.2% of tested fetuses (6/49). Our results document the value of whole-genome aCGH as a prenatal diagnostic tool and highlight the interpretation difficulties associated with copy number variations of unclear significance. 相似文献
85.
Elbek O Börekçi S Dikensoy E Kibar Y Bayram H Bakir K Dikensoy O 《Tüberküloz ve toraks》2008,56(1):87-91
Catamenial hemoptysis is a rare condition that is associated with the presence of intrapulmonary or endobronchial endometrial tissue. We describe a case of endobronchial endometriosis with catamenial hemoptysis. The patient was a 22 years-old girl presented with recurrent hemoptysis episodes for the last two years. Bronchoscopic examination was performed within first days of menses, and indicated multiple purplish-red submucosal patches in distal one third of trachea and bilateral bronchial trees that bled easily when touched. The cytological evaluation of the bronchial brushing specimens demonstrated clusters of small cuboidal cells consistent with an endometrial origin. Follow-up bronchoscopic examination at the end of the menstrual cycle revealed that the previous tracheobronchial lesions disappeared. The patient was treated with Gonadotropin-Releasing Hormone (GnRH) analogues and hormones including estrogen and progesterone therapy. Recurrent hemoptysis stopped following the medical treatment. 相似文献
86.
Kilciler M Bedir S Erdemir F Ors O Kibar Y Dayanc M 《The Kaohsiung journal of medical sciences》2008,24(1):25-30
Inverted papilloma (IP) of the urothelium accounts for 2.2% of urothelial neoplasms. The aim of this study was to report the results of 13 patients with urinary IP, pointing out the clinical features, presentations, treatment options and outcomes. The mean age and mean follow-up periods of the patients were 60.23 +/- 3.25 (range, 44-81) years and 30 (range, 6-42) months, respectively. There was no coexistence of urothelial carcinoma with IP at presentation. Cystoscopy showed a solitary papillary tumor in the bladders of 11 patients and solid pedunculated tumors in the remaining two patients. The site of development was the bladder in 12 cases (92%) and ureter in one (8%) case. Transurethral bladder tumor resection was performed in 12 cases. For the case with IP in the ureter, nephroureterectomy was performed. Pathologic examination demonstrated that seven of the 13 cases were of the trabecular type and six were of the glandular type. Of the 13 cases, two (7%) had recurrence, at 1 year and 1 month and 1 year and 5 months from initial resection. The male to female ratio was 5.5:1. Initial symptoms included macroscopic hematuria in five cases, microscopic hematuria in four, and dysuria and microscopic hematuria in three; one case was asymptomatic. IPs of the urinary bladder are benign tumors that can be treated successfully by transurethral resection and fulguration of the tumor bed. In addition, these lesions must be followed up closely for recurrence and malignant transformation. 相似文献
87.
Pulmonary arterial hypertension in a child with stage‐IV neuroblastoma after autologous hematopoietic stem cell transplantation and review of the literature
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Derya Özyörük Ayşe Esin Kibar Murat Sürücü Emine Azak Suna Emir İbrahim İlker Çetin Bahattin Tunç Namık Yaşar Özbek 《Pediatric transplantation》2015,19(7):E185-E188
PH is a rare condition with high mortality rate after pediatric HSCT. As clinical presentation is non‐specific and may mimic other conditions, a high degree of suspicion is required for diagnosis. Here, we present a patient with stage‐IV neuroblastoma who developed PAH after autologous HSCT. After exclusion of other causes of PH, we regarded that this condition was secondary to HSCT. 相似文献
88.
Sevket Balli Mehmet Zafer Aydın Vedat Gerdan İbrahim Ece Mehmet Burhan Oflaz Ayse Esin Kibar Eylem Sen Dalkiran 《Pediatric cardiology》2014,35(2):374-379
We sought to investigate whether echocardiography with tissue Doppler imaging identifies myocardial dysfunction in children with benign joint hypermobility syndrome (BJHS). This cross-sectional study enrolled 75 children with BJHS and 70 healthy children. We performed detailed echocardiography in individuals with BJHS without inherited connective tissue disorders. Any congenital or acquired cardiac disease was excluded by clinical and echocardiographic examination. Both groups were similar in terms of age, sex, and body mass index. The diameter of the aortic annulus and sinus valsalva were wider in patients with BJHS. There was no significant differences in ejection fraction or mitral and tricuspid annular plane systolic excursion between the two groups. Pulsed-wave Doppler-derived E/A ratios in mitral and tricuspid valves were similar in both groups. Deceleration time of early mitral inflow was prolonged in patients with BJHS. Mitral and tricuspid annulus Ea velocity were significantly lower in children with BJHS. Ea, Aa, and Ea/Aa ratios in the interventricular septum, left ventricle posterior wall, and right ventricle free wall were lower in patients with BJHS than in the control group. The E/Ea ratio was greater in patients with BJHS than in the control group. Isovolumic relaxation time and right-ventricular (RV) and left-ventricular (LV) myocardial performance indices (MPIs) were greater in patients with BJHS. This study showed the diastolic dysfunction in patients with BJHS. In addition, we detected increased LV and RV MPI. We believe that BJHS may affect proteins of the myocardial cytoskeleton and extracellular matrix. 相似文献
89.
90.
Safak Ozturk Mutlu Unver Burcin Kibar Ozturk Osman Bozb?y?k Varl?k Erol Eyup Kebabc? Mustafa Olmez Nihat Zalluhoglu Umit Bayol 《International journal of surgery case reports》2014,5(7):350-353