In this paper, a new type of nitrogen-doped carbon fiber/molybdenum disulfide (N-CFs/MoS2) hybrid electrode materials are prepared via a certain concentration in solvothermal synthesis followed by a high-temperature carbonization process and using the carboxymethylcellulose ammonium (CMC-NH4) as a structure-directing agent for MoS2 nanosheet growth during the solvothermal synthesis process. The addition of CMC-NH4 effectively prevents the agglomeration of MoS2 nanosheets to increase the specific surface area. Moreover, it not only serves as a carbon source to provide conductive pathways, but also introduces N atoms to improve the conductivity of the CFs and promote the transfer of electrons and ions. This ultimately increases the conductivity of the electrode materials. Thus, the as-prepared N-CFs/MoS2 hybrids exhibit excellent electrochemical performance. The specific capacitance is up to 572.6 F g−1 under a current density of 0.75 A g−1 and the specific capacitance retained 98% of the initial capacitance after 5000 cycles of charge–discharge tests at a current density of 2.5 A g−1. Moreover, the hybrids show a maximum energy density of 19.5 W h kg−1 at a power density of 94 W kg−1. Therefore, the as-prepared N-CFs/MoS2 hybrids with remarkable electrochemical properties, low cost and environment protection show potential for practical application in the development of high-performance electrochemical energy storage devices.Novel CMC-NH4-derived nitrogen-doped CFs/MoS2 hybrid electrode materials are prepared using CMC-NH4 as a structure-directing agent for MoS2 nanosheets.相似文献
Background: The effect of nucleos(t)ide analogs (NAs) versus interferon (IFN) on the occurrence of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) is controversial. We assessed whether antiviral strategy affected HCC development in CHB patients at different HCC risks.
Methods: 1112 CHB patients with antiviral therapy were included in this retrospective study. Patients treated with NAs only were classified into NAs group (n = 682) while those received IFN treatment with or without NAs were defined as IFN group (n = 430). Propensity score matching (PSM) was applied to minimize baseline differences.
Results: Totally, 31 patients developed HCC during follow-up (median 5.41 years). The cumulative HCC incidence at 10 years was significantly lower in the IFN group than NAs group (2.7% vs 8.0%, p < 0.001). Similar results were obtained in the PSM-cohort. Patients with IFN-based treatment were less likely to develop HCC than those with NAs (Hazard ratio = 0.15; 95% CI 0.04–0.66; p = 0.012). Subgroup analyses demonstrated that this superiority of IFN in reducing HCC development was obvious in patients at high- but not low-risk of HCC.
Conclusions: Reduction of HCC development was more significant in CHB patients at higher HCC risk with IFN-based therapy than NAs treatment. 相似文献
5‐Fluorouracil (5‐FU) has broadly been applied to treat colorectal cancer as one of the most effective chemotherapeutic agents. However, it frequently causes intestinal mucosal injury and related side effects, such as abdominal pain and diarrhoea, which limit the use of 5‐FU in a clinic setting. Polaprezinc has gradually become known as a mucosal protective agent for the management of gastric ulcer. This study aimed to investigate the prophylactic efficacy of Polaprezinc administered orally against intestinal mucositis induced by 5‐FU in mice on the condition that the antitumour effect could not be compromised. We induced intestinal mucositis in SPF‐grade ICR mice with 5‐FU, and evaluated intestinal damage in the absence or presence of Polaprezinc. We examined the score of diarrhoea and the loss of weight after the 5‐FU treatment and assessed the integrity of villus and the proliferation of small intestine crypt cells by haematoxylin and eosin staining and PCNA immunohistochemical detection. The antitumour effect of 5‐FU on colorectal cancer was assessed with or without Polaprezinc in a xenograft model. The result showed that Polaprezinc significantly reduced the elevated diarrhoea score and the body‐weight loss caused by 5‐FU abolished histological abnormality and crypt cell hypoproliferation in a dose‐dependent manner, without affecting 5‐FU efficacy on colon xenograft tumour in mice. We conclude that Polaprezinc could inhibit 5‐FU‐induced diarrhoea and alleviate the weight loss during 5‐FU chemotherapy, as a possible candidate for treatment and prevention of intestinal mucositis, through protecting intestinal mucosa and improving the quality of life after chemotherapy. 相似文献
Brain Imaging and Behavior - To date, our understanding of the role of abnormal hippocampal volume in imaging studies of insomnia disorders (ID) has remained in apparent contradiction. Given that... 相似文献