股骨颈骨折不同角度固定的生物力学比较研究

本文通过测量２０个股骨上段标本，Ｘ线片的压力骨小梁系统，按照其骨小梁系统采用低角度固定其股骨颈骨折标本，以临床常用角度固定的股骨颈骨折标本作为对照组，进行静力学测定。股骨上段骨小梁系统与股骨纵轴线所成角度均数为１５４．７±１．９度，骨小梁系统与股骨外侧骨皮质交点到大转子距离均数为７．３±１．０ｃｍ。低角度固定组承载力及最大承载力明显大于对照组（Ｐ＜０．０５），且有更小的旋转移位（Ｐ＜０．０５）。本研究将低角度固定概念量化，对股骨颈骨折内固定的使用有显著的临床指导意义。     

Primary study of iontophoresis of zinc ion in treatment of retinitis pigmentosa

We report here the preliminary effects of zinc iontophoresis in treatment of 26 Rp patients who had decreased zinc serum level or abnormal ratio of serum copper to zinc. Through more than 20 to 30 times of therapy, the vision of 15.38% eyes increased more than "3 lines", 4% eyes increased more than 5 degrees in the visual field, 13.46% eyes improved in dark adaptation threshold (greater than 1.0), the visual functions of the rest eyes were slightly improved or unimproved. The fundus didn't change before & after treatment. There were no changes of ERG in 8 eyes of 4 cases. In addition, the advantages and disadvantages between Zn iontophoresis and Zn compound taken orally, the improvement of vision by direct electric current therapy, the relationship between the metabolism of Zn element and Vit A and influence of Zn over the mechanism of dark adaptation were also briefly discussed.     

国产羟苯磺酸钙的药效研究

实验证实羟苯磺酸钙能显著性降低兔血小板聚集比率、血小板粘附性、血浆与血清粘度。能增强微循环、使高分子右旋糖酐造成兔眼结膜微循环障碍的血液流态得到充分的改善。     

鼻咽癌茎突后间隙侵犯的临床意义探讨

目的 探讨鼻咽癌茎突后间隙侵犯的临床意义。方法 １９９２年１２月～１９９３年１２月１９８Ⅰ－Ⅳａ期鼻咽癌住院初治患者接受受根治性放射治疗。按茎突后间隙有无侵犯分为茎后侵犯组和茎后无侵犯组。应用Ｋａｐｌａｎ－Ｍｅｉｅｒ,Ｌｏｇ－Ｒａｎｋ及卡方检验等方法对两组患者５年生存率、局部控制率和无远处转移生存率进行分析和评价。结果两组患者口咽侵犯率分别为７２．１％和１６．８％（Ｐ〈０．００１）,后组颅神经侵犯     

The Regulatory Action of the Modified Yu Ping Feng Tang on Cellular Immunity in Mice under Amputation-Induced Stress

To approach the action of modified Yu Ping Feng Tang(玉屏风汤 Jade-Screen Decoction)on cellularimmunity,an experiment was conducted in mice under amputation-induced stress.On the 3rd dayafter amputation,acute atrophy was found in the thymus,the reactivities of T-and B-lymphocytes toCon-A and LPS were decreased,the IL-2 content and its activity reduced and the activity of NK cellslowered.The high,moderate and low concentrations of the modified Yu Ping Feng(YPF)Decoction allhave antagonistic action on the above manifestations of immune inhibition.     

KATP通道开放剂KRN2391对离体大鼠心肌梗死范围的影响

目的：探讨ＡＴＰ敏感性钾通道（ＫＡＴＰ通道）开放剂ＫＲＮ２３９１（ＫＲＮ）对离体大鼠心功能及心肌梗死范围的影响。方法：用Ｌａｎｇｅｎｄｏｒｆｆ装置,观察不同浓度ＫＲＮ对冠脉灌流量及左心室压力的影响。应用离体大鼠双冠脉分别灌注芊４５ｍｉｎ缺血及２ｈ再灌注,观察药物对心肌梗死面积的影响。结果：ＫＲＮ在达到１ｕｍｏｌ／Ｌ浓度后冠脉灌流量明显增加,达２０ｕｍｏｌ／Ｌ时左室收缩压明显下降,用１ｕｍｏｌ／ＬＫ     

Adenovirus-mediated p53 gene therapy in nasopharyngeal cancer

EBV-associated nasopharyngeal cancer (NPC) occurs with high frequency in China and is a major cause of morbidity and mortality. To explore the potential use of adenovirus-mediated tumor suppressor p53 gene therapy In NPC, we first examined the in vitro effects of p53 introduced into the NPC cell lines RPMI 2650, Fadu and Detroit 562. p21(WAF1/CIP1) induction by chemotherapy was used as a functional assay which revealed that RPMI 2650 expresses wild-type p53 whereas Fadu and Detroit 562 encode mutant p53. Infection with p53-expressing adenovirus (Ad-p53) induced apoptosis and inhibited cell growth in all three NPC cell lines, regardless of the endogenous p53 status. Adenovirus infectivity was greatest in RPMI 2650 cells, with 100% of the cells expressing beta-galactosidase following Ad-LacZ infection using an MOI of 100, as compared to 20-30% infectivity with the other NPC lines. Using RPMI 2650 cells injected into nude mice, we developed an animal model for nasopharyngeal cancer. Established tumors (0.6-0.8 cm) were injected with 5x10(9) PFU Ad-LacZ, Ad-p53 or PBS in a 100 mu l volume. We found evidence for in vivo expression of beta-galactosidase or p53 and p21 up to two weeks following Ad-LacZ or Ad-p53 virus injection respectively. Objective regression of tumor size was observed at two weeks in 4/6 Ad-p53-treated tumors, but not in Ad-LacZ or PBS-treated tumors. The results provide an animal model for human nasopharyngeal cancer, and indicate a potential use of p53 in its therapy in vivo.     

论医疗事故赔偿纠纷的法律适用

由于我国医疗事故赔偿纠纷处理的有关法律、行政法规及司法解释之间存在着不统一、不配套的矛盾。因此,在审理医疗事故赔偿纠纷案件中的分歧颇大 这既不利于正确地维护医患双方的合法权益,也不利于医疗纠纷的顺利解决及社会秩序的稳定。因此,正确地认识与解决医疗事故赔偿纠纷法律适用中的矛盾,具有十分重要的意义。     

Recurrent respiratory papillomatosis: altered CD8(+) T-cell subsets and T(H)1/T(H)2 cytokine imbalance

Human papillomaviruses (HPVs) cause benign papillomas and squamous cell carcinomas in the genital and respiratory tracts. Recurrent respiratory papillomas (RRP) generate a high level of morbidity and significant mortality because of their location, resistance to treatment, and relentless recurrence that can vary in frequency in a given patient and between patients. We have found that T-cells from these patients, when exposed to or isolated from autologous papilloma tissue, have an elevated percentage of CD8(+), CD28(-) T-cells, and that T-cells from many of these patients express an increase in T(H)2-like cytokine mRNA in response to autologous papilloma tissue. Furthermore, both of these immunologic findings correlate with disease severity. These observations suggest that patients with RRP, and possibly others with refractory HPV-induced lesions, are unable to manage their disease with an appropriate and effective HPV-specific, T-cell response. This immune imbalance may be responsible for the development and severity of HPV-induced respiratory papillomatosis.