全文获取类型
收费全文 | 2183篇 |
免费 | 94篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 20篇 |
妇产科学 | 67篇 |
基础医学 | 284篇 |
口腔科学 | 18篇 |
临床医学 | 172篇 |
内科学 | 655篇 |
皮肤病学 | 20篇 |
神经病学 | 288篇 |
特种医学 | 36篇 |
外科学 | 221篇 |
综合类 | 16篇 |
一般理论 | 3篇 |
预防医学 | 106篇 |
眼科学 | 59篇 |
药学 | 169篇 |
中国医学 | 5篇 |
肿瘤学 | 121篇 |
出版年
2023年 | 6篇 |
2022年 | 74篇 |
2021年 | 100篇 |
2020年 | 18篇 |
2019年 | 17篇 |
2018年 | 49篇 |
2017年 | 33篇 |
2016年 | 28篇 |
2015年 | 49篇 |
2014年 | 68篇 |
2013年 | 80篇 |
2012年 | 148篇 |
2011年 | 183篇 |
2010年 | 96篇 |
2009年 | 68篇 |
2008年 | 120篇 |
2007年 | 185篇 |
2006年 | 159篇 |
2005年 | 155篇 |
2004年 | 134篇 |
2003年 | 143篇 |
2002年 | 131篇 |
2001年 | 5篇 |
2000年 | 13篇 |
1999年 | 7篇 |
1998年 | 8篇 |
1997年 | 10篇 |
1996年 | 10篇 |
1995年 | 16篇 |
1994年 | 9篇 |
1993年 | 6篇 |
1991年 | 9篇 |
1990年 | 4篇 |
1989年 | 10篇 |
1988年 | 9篇 |
1987年 | 8篇 |
1986年 | 12篇 |
1985年 | 10篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 10篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1976年 | 5篇 |
1973年 | 4篇 |
1971年 | 4篇 |
1967年 | 6篇 |
排序方式: 共有2285条查询结果,搜索用时 15 毫秒
31.
Tomasz Skowerski Katarzyna Nabrdalik Hanna Kwiendacz Maciej Pajak Katarzyna Mizia-Stec Zbigniew Gasior Janusz Gumprecht 《Archives of Medical Science》2022,18(3):624
IntroductionAngiopoietin-2 (Ang-2) is a novel marker of coronary artery disease (CAD) and diabetes (DM). The aim was to evaluate Ang-2 as a potential new biomarker of non-ST elevation myocardial infarction (NSTEMI) in patients with or without type 2 DM (T2DM).Material and methodsThis was a multi-center, prospective study that included 138 (males: 91/66%) consecutive patients hospitalized due to NSTEMI, T2DM, or different cardiac disorders. The subjects were divided into four study groups: group A: 28 patients with NSTEMI and T2DM; group B: 47 patients with NSTEMI without T2DM; group C: 31 patients with T2DM, without a history of CAD; group D: 32 patients as a control group. Patients with NSTEMI underwent urgent coronarography. Clinical characteristics including biomarkers (hs-CRP, hsTnT, NT-proBNP, VEGF, HbA1c), SYNTAX SCORE, type of intervention (PCI vs. CABG), and number of implanted stents were taken into account in the analysis.ResultsSerum Ang-2 concentrations were significantly higher in patients with NSTEMI (group A: 1769 pg/ml; group B: 1757 pg/ml) and patients with T2DM (group C: 1993 pg/ml) as compared to the patients without CAD and without T2DM (group D: 866.8 pg/ml; p < 0.05). The prognostic accuracy of Ang-2 in NSTEMI diagnosis was determined with the area under the ROC curve (area under curve (AUC) = 0.63).ConclusionsAngiopoietin-2 serum concentration is elevated in the presence of NSTEMI in patients with and without T2DM and does not correspond to the degree of myocardial injury and hemodynamic status. Ang-2 remains elevated also in patients with T2DM without a history of CAD. 相似文献
32.
Katarzyna Miekus Marta Pawlowska Ma?gorzata Seku?a Grazyna Drabik Zbigniew Madeja Dariusz Adamek Marcin Majka 《Oncotarget》2015,6(12):10086-10101
Cervical cancer is one of the leading causes of death among women suffering from tumors. Current treatment options are insufficient. Here, we investigated the MET receptor as a potential molecular target in advanced cervical cancer. Downregulation of MET receptor expression via RNA interference in different cervical carcinoma cell lines dramatically decreased tumor growth and forced tumor differentiation in vivo. MET receptor silencing also led to a dramatic decrease in cell size and a decrease in proliferation rate under normal and stress conditions. MET receptor downregulation also resulted in decreased cyclin D1 and c-myc levels but did not increase apoptosis. Subsequent experiments showed that downregulation of the MET receptor decreased the expression of a key regulator of the epithelial-to-mesenchymal transition, SLUG. and increased the expression of E-cadherin, a hallmark of the epithelial phenotype. Moreover, MET downregulation impairs expression and signaling of CXCR4 receptor, responsible for invasive phenotype.Taken together, our results strongly suggest that the MET receptor influences the oncogenic properties of cervical carcinoma cells in vitro and in vivo. These findings highlight a unique role of the MET receptor in cervical carcinoma cells and indicate the MET receptor as a potential therapeutic target for advanced cervical carcinoma. 相似文献
33.
Therapeutic plasma exchange for thrombotic thrombocytopenic purpura with refractory thrombocytopenia
下载免费PDF全文
![点击此处可从《Journal of clinical apheresis》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Nolan Maloney Isabella Martin Zbigniew M. Szczepiorkowski Nancy M. Dunbar 《Journal of clinical apheresis》2018,33(3):436-438
Thrombotic thrombocytopenic purpura (TTP) is an acute, life‐threatening illness with disseminated platelet‐rich thromboses of small vessels that variably presents with the classic clinical “pentad” of microangiopathic hemolytic anemia, thrombocytopenia, fever, altered mental status, and acute kidney injury. Most cases are caused by an acquired autoantibody to ADAMTS13, a metalloproteinase that cleaves large von Willebrand Factor (vWF) multimers. The mainstay of treatment is daily therapeutic plasma exchange (TPE), sometimes with adjunctive pharmacologic immunosuppression. TPE is generally continued until the platelet count is greater than 150 × 103/µL and the lactate dehydrogenase is near normal for 2‐3 consecutive days. Unfortunately, there is no clear guidance for when thrombocytopenia is refractory for a prolonged period of time. The following case describes such a scenario in which consecutive ADAMTS13 activity and inhibitor levels were used to guide the decision to stop treatment with TPE in a patient who failed to recover their platelet count. 相似文献
34.
Andrzej Nowicki Zbigniew Trawinski Barbara Gambin Wojciech Secomski Michał Szubielski Marzena Parol Robert Olszewski 《Ultrasound in medicine & biology》2018,44(6):1187-1197
A high-frequency scanning system consisting of a 20-MHz linear array transducer combined with a 20-MHz pulsed Doppler probe was introduced to evaluate the degree of radial artery flow-mediated dilation (FMD [%]) in two groups of patients after 5?min of controlled forearm ischemia followed by reactive hyperemia. In group I, comprising 27 healthy volunteers, FMD (mean?±?standard deviation) was 15.26?±?4.90% (95% confidence interval [CI]: 13.32%–17.20%); in group II, comprising 17 patients with chronic coronary artery disease, FMD was significantly less at 4.53?±?4.11% (95% CI: 2.42%–6.64%). Specifically, the ratio FMD/SR (mean?±?standard deviation), was equal to 5.36?×?10?4?±?4.64?×?10?4 (95% CI: 3.54?×?10?4 to 7.18?×?10?4) in group I and 1.38?×?10?4?±?0.89?×?10?4 (95% CI: 0.70?×?10?4 to 2.06?×?10?4) in group II. Statistically significant differences between the two groups were confirmed by a Wilcoxon–Mann–Whitney test for both FMD and FMD/SR (p?<0.01). Areas under receiver operating characteristic curves for FMD and FMD/SR were greater than 0.9. The results confirm the usefulness of the proposed measurements of radial artery FMD and SR in differentiation of normal patients from those with chronic coronary artery disease. 相似文献
35.
36.
Beata Krasińska MD PhD Maciej Banach PhD Małgorzata Karolczak-Kulesza MD PhD Zbigniew Krasiński PhD Jerzy Głuszek PhD Andrzej Tykarski PhD 《Journal of clinical hypertension (Greenwich, Conn.)》2012,14(10):701-710
J Clin Hypertens (Greenwich). 2012;14:701–710. ©2012 Wiley Periodicals, Inc. The authors aimed to determine the effect of the time of hypotensive drug administration on the progress of degenerative changes within the optic nerve in patients with hypertension and glaucoma. Two groups were included in the study: group A comprised patients-dippers taking drugs in the mornings, and group B comprised patients-nondippers taking drugs both in the mornings and in the evenings. After 6 months, group B showed significant drops in nocturnal diastolic blood pressure (BP) (month 1=73.27 mm Hg vs month 6=67.50 mm Hg), nocturnal mean BP (89.34 vs 84.65 mm Hg), and minimum diastolic BP (50.74 vs 44.03 mm Hg). Group B also showed significant reductions in nocturnal ocular perfusion pressure (43.0 vs 39.73), retinal nerve fiber layer thickness (131.31 vs 113.12 μm), and flow in the eye vessels. Taking hypotensive drugs in the evening may significantly decrease blood flow in the eye arteries, cause degenerative changes within the optic nerves, and result in greater loss in the field of vision. 相似文献
37.
Piotr Skórczewski Zbigniew Jan Mudryk Justyna Miranowicz Piotr Perlinski Marta Zdanowicz 《Oceanological and hydrobiological studies.》2014,43(1):41-48
Antibiotic resistance of Staphylococcus-like organisms (STLO) isolated from a recreational sea beach located on the southern coast of the Baltic Sea was studied. The results of the present study showed that STLO inhabiting sand and seawater of the beach strongly differed in the resistance level to tested antibiotics. These microorganisms were most resistant to ampicillin, penicillin, oxytetracycline and susceptible to gentamicin, neomycin and streptomycin. Moreover, the level of antibiotic resistance among bacteria isolated from different parts of the beach also differed. Bacteria inhabiting the seawater, shoreline and the middle part of the beach were more antibiotic-resistant than bacteria isolated from the dune. The majority of bacteria inhabiting the seawater and sand were resistant to 3–8 antibiotics out of 12 tested in this study. Generally, there was no difference in antibiotic resistance between Staphylococcus-like organisms isolated from the surface and subsurface sand layers. STLO strains isolated from Ustka Beach were most resistant to β-lactam and tetracycline antibiotics, and most susceptible to aminoglycosides. 相似文献
38.
Rakowski Tomasz Siudak Zbigniew Dziewierz Artur Plens Krzysztof Kleczyński Paweł Dudek Dariusz 《Journal of thrombosis and thrombolysis》2018,45(1):151-157
Journal of Thrombosis and Thrombolysis - According to guidelines, it is recommended to give P2Y12 inhibitors (preferably ticagrelor or prasugrel) at the time of first medical contact in patients... 相似文献
39.
40.
Anna Zawadzka Iwona Łozińska Zuzanna Molęda Mirosława Panasiewicz Zbigniew Czarnocki 《Journal of pineal research》2013,54(4):435-441
Novel inhibitors of cholinesterases, especially butyrylcholinesterase (BuChE), were obtained by coupling melatonin–tacrine heterodimers via the carbamate bond. Compounds 14a‐i possessed potent cholinesterase inhibitory activity (with IC50 values as low as 1.18 nm for acetylcholinesterase (AChE) and 0.24 nm for butyrylcholinesterase (BuChE)). These heterodimers exhibit selectivity toward BuChE, being from 4‐ to 256‐fold more active toward BuChE than AChE, but still acting as better AChE inhibitors than tacrine 4 . 相似文献