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排序方式: 共有1033条查询结果,搜索用时 15 毫秒
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Allegretti Jessica R. Kassam Zain Chan Walter W. 《Digestive diseases and sciences》2018,63(1):193-197
Digestive Diseases and Sciences - Fecal microbiota transplantation (FMT) is safe and effective for recurrent Clostridium difficile infection (rCDI) and often involves terminal ileal (TI) stool... 相似文献
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AbstractMycotoxins pose severe health hazards in animals, humans, and poultry birds. More than 400 chemically different mycotoxins have been identified to date. Twenty-five percent of world’s crops are potentially contaminated with mycotoxins. Luckily, nature has provided the ruminants a unique property of inactivating and detoxifying most of the mycotoxins with the help of microflora and microfauna present within their ruminal fluid; however, unfortunately avian species lack such ability putting them at high risk to the deleterious effects of mycotoxins. This review elaborates different strategies for diagnosis, prevention and control of mycotoxins. 相似文献
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Zain Chagla Natasha Aleksova Jaclyn Quirt Joel Emery Christian Kraeker Shariq Haider 《The Canadian Journal of Infectious Diseases & Medical Microbiology》2014,25(4):225-226
Melioidosis is an infection endemic to Southeast Asia and Northern Australia, and is associated with significant morbidity and mortality. The present report describes a case of chronic melioidosis in a returning traveller from the Philippines. Clinical suspicion of this illness is warranted in individuals with a history of travel to endemic regions. Safety in handling clinical specimens is paramount because laboratory transmission has been described. 相似文献
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Activation and expansion in culture with rIL-2 of peripheral blood (PB) and/or bone marrow (BM) specimens derived from children with ALL and ANLL, with active disease (AP) and in remission were studied (RP). Baseline NK cytolytic activity from AP was found to be depressed, whereas RP-derived cells had normal NK activity, as assayed against K562 targets. Culture in rIL-2 significantly enhanced the NK activity of both AP- and RP-derived cells and generated LAK activity, as assayed by 4-hour 51Cr release, against NK-resistant Raji cell line and against fresh, allogeneic, and autologous tumor cells. Lytic activity against fresh, cryopreserved leukemia blasts was of lower than that found against cell lines. In three patients higher lytic activity against autologous than against allogeneic blasts was demonstrated. Expansion in culture with rIL-2 varied from twofold to 120-fold. rIL-2 activation and expansion was better in RP than in AP. The predominant phenotype of activated cells, as determined by flow cytometry, was [mean % (SD)]: CD3- = 54 (12), CD8+ = 55 (17), and NKH1+ = 26 (7). The consistently high level of CD8+ cells was accompanied by very low levels of CD4+ cells: mean = 11% (14). Double-marker analysis showed mean of 33% (10) for CD3+/NKH1+ cells and mean = 32 (11) for CD8+/NKH1+ cells, implying that these populations were overlapping. Kinetics of expression of cell surface markers during 2 to 3 weeks in culture showed that CD8+ and NKH1+ enrichment occurred during the first week and lasted for up to 4 weeks, whereas CD4+ expression decreased after the second week. A significant decrease in the expression of IL-2 receptors (CD25) was observed from the second week of culture. This study shows the feasibility of in vitro generation of killer cells from PB and BM of pediatric leukemia patients. 相似文献
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Epidemiology and Risk Factors for Bloodstream Infections in a Home Parenteral Nutrition Program 下载免费PDF全文
Sam Elfassy MD MBA FRCPC Zain Kassam MD FRCPC Faizan Amin MD Khurram J. Khan MSc MD FRCPC Shariq Haider MD FRCPC FACP DTMH CCST 《JPEN. Journal of parenteral and enteral nutrition》2015,39(2):147-153
Background: An increasing number of patients with intestinal failure are receiving home parenteral nutrition (HPN). Associated complications include bloodstream infections (BSIs), but data on rates and risk factors for HPN‐related BSIs are scarce. Methods: A retrospective review was conducted of patients enrolled in the regional HPN program between 2001 and 2008. Demographic information and data on indication for HPN, duration of PN therapy, type and date of insertion of central venous access device, and blood culture results were recorded. Results: In total, 155 patients (165 courses of HPN) were included for a total of 45,876 catheter days. The mean patient age was 49 years, and 105 (64%) patients were female. A total of 105 organisms were cultured from 93 distinct episodes of BSIs. The rate of BSI was found to be 2.0 per 1000 catheter days, but excluding BSIs with a single positive culture of coagulase‐negative staphylococcus and diphtheroid bacilli, the rate of infection was 1.4 per 1000 catheter days. Male sex and underlying malignancy were significant predictors of BSI, with hazard ratios of 1.69 (95% confidence interval [CI], 1.14–2.60; P = .009) and 2.38 (95% CI, 1.53–3.50; P < .001). Conclusion: In a large heterogeneous group of HPN patients, the BSI rate ranged between 1.4 and 2.0 infections per 1000 catheter days. Isolated organisms were similar to those found in hospitalized patients. Male sex and underlying malignancy were significant risk factors for BSI. These high‐risk patients are likely to benefit from interventions aimed at reducing BSIs. 相似文献
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Virk Zain M. Song Andrew B. Badran Yousef R. Al-Samkari Hanny 《Journal of thrombosis and thrombolysis》2022,54(2):255-259
Journal of Thrombosis and Thrombolysis - Heyde syndrome is characterized by the co-occurrence of aortic stenosis and bleeding gastrointestinal angiodysplasias, often with acquired von Willebrand... 相似文献