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Biomedical Engineering - Techniques for spectral processing of electrocardiographic and electroencephalographic signals using spectral processors of different types are considered. A new technique... 相似文献
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Zaichenko K. V. Kordyukova A. A. Logachev E. P. Luchkova M. N. 《Biomedical engineering》2021,55(1):31-35
Biomedical Engineering - Radar technologies of signal processing have been used to implement a highly effective new proprietary technique for studying the bioelectric activity of the heart —... 相似文献
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Given the limited success of clinical HIV vaccine trials, new vaccine strategies are needed for the HIV pipeline. The present study explored the novel concept that a live enteric virus, with limited disease potential, is a suitable vaccine vector to elicit HIV-specific immune responses in the gut mucosa of immunized mice. Two coxsackievirus B4 (CVB4) vaccine vectors were designed to induce HIV-specific B or T cell responses. A B cell immunogen, CVB4/gp41(2F5), was constructed by expressing an epitope from the membrane proximal external region (MPER) of gp41 as a structural peptide within a surface loop of a capsid protein of CVB4. The T cell immunogen, CVB4/p24(73(3)), was constructed previously by expressing a gag p24 sequence as a non-structural peptide at the amino-terminus of the CVB4 polyprotein. The CVB4/gp41(2F5) recombinant was antigenic in mice and elicited anti-gp41 antibodies in both the mucosal and systemic compartments. The route of immunization affected the antibody response since oral delivery of CVB4/gp41(2F5) induced anti-gp41 antibodies in the mucosal but not in the systemic compartment while parenteral delivery induced anti-gp41 antibodies in both compartments. In contrast, oral immunization with CVB4/p24(73(3)) elicited both mucosal and systemic gag p24-specific T cell responses. Since coxsackieviruses are ubiquitous in the human population, a key question is whether pre-existing vector immunity will inhibit the ability of a CVB4-based vaccine to induce HIV-specific immune responses. We show that pre-existing vector immunity did not preclude the development of mucosal anti-gp41 antibodies or gag p24-specific T cell responses after oral immunization with the CVB4/HIV recombinants. We suggest that the CVB4/HIV recombinants have the potential to be a viable vaccine product because of ease of delivery, safety, immunogenicity, ease of large-scale production, and storage conditions requiring cold-chain temperatures provided by refrigeration. 相似文献
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Pavlova I. V. Rysakova M. P. Zaichenko M. I. Broshevitskaya N. D. 《Neuroscience and behavioral physiology》2020,50(1):126-136
Neuroscience and Behavioral Physiology - Behavior in rats with different levels of freezing in a classical defensive conditioned reflex was compared on acquisition of conditioned passive and active... 相似文献
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