芳香酶抑制剂依西美坦(Exemestane)的合成

目的：合成依西美坦并改进合成工艺。方法：以雄甾烯一酮为原料，经Mannich反应、溴化、脱溴等数步反应制得依西美坦。结果：所得产物经元素分析。柴外光谱，红外光谱，核磁共振谱及质谱等确证了结构。结论：此路线是可行的。     

抗有机磷酸酯药物的合成及其构效关系的研究

本文报道一类双吡啶季铵盐化合物,对抗小鼠有机磷酸酯化合物中毒有效,其中一些化合物的抗毒效价超过了文献报道的HI-6,HGG-42的水平。为探讨其构效关系,用EHMO方法计算了23个化合物的分子轨道指数,从中发现吡啶环Ⅱ和羰基可能是化合物的活性部位,影响抗毒作用的因素有二个,并再次设计合成了二个新化合物,量化计算预测的抗毒效价与药理结果一致。化合物与胆碱N受体结合有较强的选择性,根据计算,提出了其可能的作用模式,推测N受体活性部位除有文献报道的阴离子部位、亲酯中心、疏水区域外,还可能有轨道作用部位。     

年龄及人参皂甙 Rg1 对大鼠大脑皮层 NO 释放的影响

探讨了NO与衰老的关系及与Rg1抗衰老机制的关系。用Griess法,³H-L-精氨酸转化法分别研究大鼠大脑皮层细胞NO含量及NOS活性,观察其随龄变化及人参皂甙Rg1(Rg1)对老年鼠NO及NOS的影响。实验表明,成年鼠(9月龄)与青年鼠(3月龄)NO含量及NOS活性无显著性差异。老年鼠(27月龄)脑皮层NO含量明显高于青年鼠和成年鼠,NOS活性也明显增高。老年鼠给予Rg1后可显著减少大脑皮层NO含量和降低NOS活性。结果提示,NO与衰老关系密切,Rg1的抗衰老作用与其对NOS活性的抑制有关。     

肠易激综合征重叠功能性消化不良患者的临床症状、生存质量及精神心理状态分析

目的 研究肠易激综合征（IBS）重叠功能性消化不良（FD）患者的临床症状、生存质量、焦虑抑郁状态及就医情况,为临床诊治提供依据。 方法 选取2012年9月至2013年5月就诊于四川大学华西医院消化门诊的IBS患者,根据是否重叠FD症状分为2组,选10名健康志愿者作为正常对照组。通过发放胃肠道症状评估量表（GSRS）、汉化版IBS-生存质量量表（ChIBS-QOL）以及汉密尔顿焦虑量表（HAMA）14项及汉密尔顿抑郁量表（HAMD）17项版本,比较所有受试者的临床症状、生存质量、焦虑抑郁状态及就医情况。 结果 60例IBS患者中25例（41.7%）重叠FD症状（IBS-FD）。IBS-FD患者的GSRS评分高于单纯IBS患者及健康志愿者,差异有统计学意义（P<0.05）;IBS-FD患者就医次数多于单纯IBS患者,差异有统计学意义（P<0.05）。健康志愿者无焦虑及抑郁发生,单纯IBS患者多见轻度焦虑及抑郁,IBS-FD患者多见中-重度焦虑及抑郁;IBS-FD患者焦虑及抑郁发病率高于单纯IBS患者（分别为80.0%比51.4%,76.0%比48.6%）,差异有统计学意义（P<0.05）。进一步分型提示重叠FD症状的便秘型IBS（IBS-C-FD）患者的GSRS评分最高、焦虑发病率最高及ChIBS-QOL评分最高。 结论 IBS-FD患者尤其IBS-C-FD患者较单纯IBS患者的胃肠道症状更严重、焦虑抑郁程度更重,生存质量更差。     

Localization of the gene for rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration to chromosome 17q21

Rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration (PPND) is a neurodegenerative disorder which begins later in life (> 30 years of age) and is characterized by rapidly progressive parkinsonism, dystonia, dementia, perservative vocalizations and pyramidal tract dysfunction. The disease is observed in a large American family that includes almost 300 members in nine generations with 34 affected individuals. In this kindred evidence for linkage to chromosome 17q21 was obtained with a maximum lod score of 9.08 for the D17S958 locus. Multilocus analysis positions the disease gene in an approximately 10 cM region between D17S250 and D17S943. Notably, the disease locus for a clinically distinct familial neurodegenerative disease named 'disinhibition-dementia-parkinsonism- amyotrophy complex' (DDPAC) was recently mapped to the same region of chromosome 17, suggesting that PPND and DDPAC may possibly originate from mutations in the same gene.      

Sarcomatous transformation in diaphyseal aclasis

Multiple hereditary exostosis (or diaphyseal aclasis) is a condition characterized by the development of multiple osteochondromas. The tendency for malignant transformation into chondrosarcoma is well known. Malignancy typically arises from the cartilaginous cap of the osteochondroma. Radiographs supplemented by computed tomography have an important role in the diagnosis of this condition. Magnetic resonance imaging shows the features of sarcomatous change and aids in differentiating malignancy from pseudotumours.