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991.
Yuto Sato Kazuhisa Okamoto Masahide Fukuda Yuzo Oyama Yoshihiko Kondo Haruto Nishida Tsutomu Daa Kazumi Togo Akira Sonoda Kensuke Fukuda Osamu Matsunari Ryo Ogawa Koichi Honda Kazuhiro Mizukami Tadayoshi Okimoto Masaaki Kodama Kazunari Murakami 《Internal medicine (Tokyo, Japan)》2021,60(6):839
Cholesterol crystal embolization (CCE) shows a poor prognosis and it can cause ischemic organ damage due to a cholesterol embolism from atherosclerotic lesions in large blood vessels. Such an embolism mainly affects the kidneys and skin, although cases involving digestive organs have also been reported. We encountered an autopsy case of CCE with damage mainly to the digestive organs, including the pancreas. The patient had non-specific abdominal symptoms or image findings. Symptomatic therapy failed to save him. CCE can involve the digestive organs, and so must be differentiated from abdominal pathologies. Moreover, conventional treatments may be ineffective, and new treatments might thus be necessary. 相似文献
992.
993.
Madoka Yanagawa Hiroyuki Umegaki Tomoko Uno Khookhor Oyun Naoko Kawano Hitoshi Maeno Kunio Yamanouchi Yuzo Sato 《Geriatrics & Gerontology International》2011,11(3):341-347
Aim: The number of elderly with cognitive dysfunction has been increasing in developed countries. Several studies have shown that diabetes is a risk factor for declines in cognitive function and, recently, numerous studies have demonstrated that exercise improves insulin resistance (IR). However, no studies have been undertaken to examine the relationship between IR and cognitive dysfunction. Methods: Sixteen elderly diabetic patients participated in this study (mean age 70.9 ± 3.7 years). They were divided into control and training groups, and the training group was instructed to exercise 4 days per week for 12 weeks using horse riding simulation equipment (JOBA). Insulin sensitivity was measured by the euglycemic clamp technique and several tests to assess cognitive function, such as the Mini‐Mental State Examination (MMSE), were performed. Results: There were no statistically significant differences between the control and training groups in the baseline data. The differences of glucose infusion rate values and delayed word list scores, between baseline and the follow up, were significantly correlated (P = 0.024). In addition, changes in fasting blood sugar (FBS) and in the Trail Making Test B (TMT‐B) score were also correlated (P = 0.035). Conclusion: The current study showed that a 12‐week exercise intervention program did not significantly improve IR in elderly diabetic patients. However, changes in IR were associated with improvements in memory function, and reduced FBS was associated with improvements in TMT‐B. Geriatr Gerontol Int 2011; 11: 341–347. 相似文献
994.
Masashi Utsumi Yuzo Umeda Hiroshi Sadamori Takeshi Nagasaka Akinobu Takaki Hiroaki Matsuda Susumu Shinoura Ryuichi Yoshida Daisuke Nobuoka Daisuke Satoh Tomokazu Fuji Takahito Yagi Toshiyoshi Fujiwara 《Transplant international》2013,26(8):842-852
Acute renal injury (ARI) is a serious complication after liver transplantation. This study investigated the usefulness of the RIFLE criteria in living donor liver transplantation (LDLT) and the prognostic impact of ARI after LDLT. We analyzed 200 consecutive adult LDLT patients, categorized as risk (R), injury (I), or failure (F), according to the RIFLE criteria. ARI occurred in 60.5% of patients: R‐class, 23.5%; I‐class, 21%; and F‐class, 16%. Four patients in Group‐A (normal renal function and R‐class) and 26 patients in Group‐B (severe ARI: I‐ and F‐class) required renal replacement therapy (P < 0.001). Mild ARI did not affect postoperative prognosis regarding hospital mortality rate in Group A (3.2%), which was superior to that in Group B (15.8%; P = 0.0015). Fourteen patients in Group B developed chronic kidney disease (KDIGO stage 3/4). The 1‐, 5‐ and 10‐year survival rates were 96.7%, 90.6%, and 88.1% for Group A and 71.1%, 65.9%, and 59.3% for Group B, respectively (P < 0.0001). Multivariate analysis revealed risk factors for severe ARI as MELD ≥20 [odds ratio (OR) 2.9], small‐for‐size graft (GW/RBW <0.7%; OR 3.1), blood loss/body weight >55 ml/kg (OR 3.7), overexposure to calcineurin inhibitor (OR 2.5), and preoperative diabetes mellitus (OR 3.2). The RIFLE criteria offer a useful predictive tool after LDLT. Severe ARI, defined beyond class‐I, could have negative prognostic impact in the acute and late postoperative phases. Perioperative treatment strategies should be designed and balanced based on the risk factors for the further improvement of transplant prognosis. 相似文献
995.
Estibaliz Romaratezabala Fábio Yuzo Nakamura Daniel Castillo Ilargi Gorostegi-Anduaga 《Research in sports medicine (Print)》2018,26(2):230-243
The purpose of the study was to analyse the effect of two warm-up protocols of different duration on physical performance, perceived load and perception of being ready for a match in handball players. Eighteen handball players were randomly divided into two groups (Wup34min, warm-up protocol of 34 min, Wup17min, warm-up protocol of 17 min). Before and after the warm-up protocols, they performed a battery of physical tests and recorded their perception of feeling ready for a match. At the end of the warm-up protocols, all the players evaluated their differentiated perceived effort (dRPE). The results showed that neither of the protocols significantly modified (p > 0.05) the players’ physical performance. However, the Wup34min group showed higher values in the differentiated warm-up perceived load (dRPE-WL) (p < 0.01, TE = 0.97–1.27, high) than the Wup17min group. The players with a greater perceived muscular load (RPEMUSC) experienced a greater decrease in their acceleration capacity (r = 0.48–0.49, p < 0.05). In spite of the fact that neither of the warm-up protocols significantly modified the players’ physical performance, a greater perceived muscular load may cause a greater decrease in acceleration capacity. 相似文献
996.
Yasuo Iwadate Tomoo Matsutani Yuzo Hasegawa Natsuki Shinozaki Yoshinori Higuchi Naokatsu Saeki 《Journal of neuro-oncology》2011,102(3):443-449
Despite the accumulating evidences of high chemosensitivity especially in anaplastic oligodendrogliomas with loss of chromosomes
1p and 19q, the optimal management strategy for low-grade tumors using the 1p/19q information remains controversial. We have
treated all low-grade oligodendrogliomas by a chemotherapy-preceding strategy without radiotherapy, and here we analyzed the
survival outcomes of 36 consecutive patients in relation to 1p/19q status. The treatment protocol was as follows: (1) simple
observation after gross total resection, and (2) modified PCV chemotherapy for postoperative residual tumors or recurrence
after total resection. The 1p and 19q status were analyzed by fluorescence in situ hybridization. The median follow-up period
was 7.5 years and no patient was lost during the follow-up periods. 1p/19q co-deletion was observed in 72% of the patients,
and there was no significant association between 1p/19q co-deletion and chemotherapy response rate. The 5- and 10-year progression-free
survival (PFS) rate was 75.1 and 46.9%, respectively, and the median PFS was 121 months for 1p/19q-deleted tumors and 101 months
for non-deleted tumors (log-rank test: P = 0.894). Extent of surgery did not affect PFS (P = 0.685). In contrast, the elder patients (>50) had significantly shorter PFS (P = 0.0458). Recurrent tumors were well controlled by chemotherapy irrespective of 1p/19q status, and 35 out of 36 patients
survived without receiving radiotherapy. The 5- and 10-year overall survival rates were 100 and 93.8%, respectively. Two of
the patients in their sixties (29%) suffered from severe cognitive dysfunctions and marked brain atrophy following chemotherapy
alone. These results show that low-grade oligodendrogliomas could be successfully treated by surgical resection and nitrosourea-based
chemotherapy alone without radiotherapy irrespective of 1p/19q status. 相似文献
997.
Tomokazu Fuji Yuzo Umeda Akihiro Nyuya Fumitaka Taniguchi Takashi Kawai Kazuya Yasui Toshiaki Toshima Kazuhiro Yoshida Toshiyoshi Fujiwara Ajay Goel Takeshi Nagasaka 《International journal of cancer. Journal international du cancer》2019,144(9):2169-2180
Because of the different forms of circulating miRNAs in plasma, Argonaute2 (Ago2)-miRNAs and extracellular vesicles (EV-miRNAs), we examined the two forms of extracellular miRNAs in vitro and developed a unique methodology to detect circulating Ago2-miRNAs in small volumes of plasma. We demonstrated that Ago2-miR-21 could be released into the extracellular fluid by active export from viable cancer cells and cytolysis in vitro. As miR-21 and miR-200c were abundantly expressed in both metastatic liver sites and primary lesions, we evaluated Ago2-miR-21 as a candidate biomarker of both active export and cytolysis while Ago2-miR-200c as a biomarker of cytolysis in plasma obtained from colorectal cancer (CRC) patients before treatment and in a series of plasma obtained from CRC patients with liver metastasis who received systemic chemotherapy. The measurement of Ago2-miR-21 allowed us to distinguish CRC patients from subjects without CRC. The trend in ΔCt values for Ago2-miR-21 and -200c during chemotherapy could predict tumor response to ongoing treatment. Thus, capturing circulating Ago2-miRNAs from active export can screen patients with tumor burdens, while capturing them from passive release by cytolysis can monitor tumor dynamics during chemotherapy treatment. 相似文献
998.
Masafumi Seki MD Katsuyoshi Koh MD Takeshi Inoue MD Yuzo Tomita MD PhD Motohiro Kato MD PhD Masaki Shimizu MD PhD Eriko Morishita MD PhD Ryoji Hanada MD 《Pediatric blood & cancer》2013,60(3):503-505
Prothrombin (Factor II, FII) deficiency is an extremely rare autosomal recessive condition with an estimated incidence of 1:2 million. As severe and life‐threatening bleeding is rare in FII deficiency, on demand therapy with administration of prothrombin complex concentrates (PCCs) or fresh frozen plasma is generally performed, and prophylactic therapy for FII deficiency has been reported in only three cases. Thus, its optimal dosage and schedule has remained uncertain. Here we report a case of severe prothrombin deficiency with a novel frameshift mutation of the F2 gene, who was started on prophylactic administration. Pediatr Blood Cancer 2013; 60: 503–505. © 2012 Wiley Periodicals, Inc. 相似文献
999.
1000.