Determinants of reflux perception in patients with non-erosive reflux disease who have reflux-related symptoms on potassium-competitive acid blocker therapy

Esophagus - This study investigated potential determinants of reflux perception in patients with non-erosive reflux disease (NERD) who had reflux-related symptoms on potassium-competitive acid...     

Hepatocellular carcinoma with direct invasion to the stomach causing gastrointestinal hemorrhage

A 54-year-old man had undergone transcatheter arterial embolization (TAE) three times to treat hepatitis B virus-related hepatocellular carcinoma (HCC), but recurrence was found in June 2005. A large tumor in the left lateral portion of the liver showed extrahepatic growth and was attached to the gastric wall. TAE was performed a forth time. In September 2005, the patient was admitted with worsening anemia. Computed tomography and upper gastrointestinal endoscopy revealed that the HCC had directly invaded the stomach and caused gastrointestinal hemorrhage. Endoscopic hemostasis was effective, but the patient died because of worsening hepatic failure.     

Validity and reliability of the Karitane Parenting Confidence Scale among Japanese mothers

The Karitane Parenting Confidence Scale is a valid and reliable measure used to assess perceived parental self‐efficacy, which is a critical component in facilitating adaptation to parenthood. In the current study, we translated the original version of the scale, developed in Australia, into Japanese and examined the validity and reliability of the translation, including its factor structure. A Web‐based survey was administered to 316 mothers of children aged 0–12 months between May and June 2016. The results revealed that the Japanese version had a two factor structure: “self‐efficacy for infant care” and “self‐efficacy for parental role”. The concurrent/convergent validity of the Japanese version was examined with an acceptable Cronbach's alpha coefficient for each subscale. The present findings indicate that the Japanese version of the Karitane Parenting Confidence Scale is a valid and reliable measure to assess parenting self‐efficacy among Japanese mothers of infants. The results suggest further assessment of parental self‐efficacy by using each subscale. Additionally, future studies should replicate the factor structures across varied or large populations.     

Paraneoplastic Opsoclonus-myoclonus Syndrome with Anti-Hu and Anti-SOX-1 Antibodies after Immune-checkpoint Inhibitor Treatment Combined with Chemotherapy in a Patient with Small-cell Lung Cancer

A 69-year-old man with advanced small-cell lung cancer achieved partial remission after 3 courses of immunochemotherapy that included atezolizumab. Ten days after the last treatment, he developed paraneoplastic opsoclonus-myoclonus syndrome and required mechanical ventilation. Serology testing detected anti-Hu and anti-SOX-1 antibodies. Despite steroid pulse therapy, various anticonvulsants, continuous intravenous sedation, and a fourth course of chemotherapy without atezolizumab, his condition failed to improve. Paraneoplastic opsoclonus-myoclonus syndrome with autoantibodies after immune-checkpoint inhibitor treatment has not been reported previously. Although a causal relationship between immune-checkpoint inhibitors and paraneoplastic syndromes has been suggested, the mechanism remains unknown.