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91.
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醋氨己酸锌在大鼠的药代动力学 总被引:2,自引:1,他引:1
测定了醋氨已酸锌(ZAC)在大鼠体内的药代动力学。结果表明:大鼠poZAC吸收迅速,给药后1.5h即可达峰,其后稍快下降。3个剂量组的吸收峰时及半衰期基本一致,T1/2约在1.5h,峰浓度、AUC及CL/F呈剂量依赖关系。ZAC在大鼠的药代动力学模型为一室模型。组织分布的实验结果表明:服药2h后药物可广泛分布于各组织中,主要集中在胃、肠;肾、肝、血浆及肺次之;心、脾、脑较低;肌肉、子宫未检出。6h后胃中含锌量稍降,肺中含量变化不大,其它组织的药物浓度普遍明显下降,表明该药在组织中不易蓄积。ZACpo后主要经粪排出,尿及胆汁仅排出少量药物。 相似文献
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D L Conine M Yum R C Martz G K Stookey R B Forney 《Toxicology and applied pharmacology》1976,35(1):21-28
For 30 days, groups of 12–19 Wistar rats (divided according to sex) were dosed daily by gavage with distilled water or with 20, 100, or 175 mg/kg sodium pentafluorostannite. On Days 14 and 29, blood was collected from five rats in each group to determine hemoglobin concentration and packed cell volume. On Days 15 and 30, rats were sacrificed, blood collected, and serum urea nitrogen (BUN), direct and total bilirubin, SGOT activity, inorganic phosphorus, calcium and glucose concentrations were determined. A necropsy was performed on each rat, its organs weighed, and sections prepared for microscopic examination. After 15 and 30 days, growth was depressed in a dose-related manner. Serum glucose concentration was also lowered. Microscopic findings in organs were generally unremarkable except for degenerative changes of the proximal tubular epithelium of the kidneys in 15–20% of the animals in the 175-mg/kg groups. Animals that died spontaneously displayed signs suggestive of cardiac failure, including congestion of the liver, spleen, lungs and/or kidneys. In addition, most had moderate to severe renal tubular necrosis. 相似文献
96.
We have studied a case of renal angiomyolipoma by electron microscopy and found juxtaglomerular cells with typical rhomboid and spherical granules, in addition to smooth muscle cells, fat cells, and abnormal blood vessels. To our knowledge, this is the first ultrastructural demonstration of juxtaglomerular cells in renal angiomyolipoma. 相似文献
97.
Kevin J. Lavelle Alan M. Golichowski Lettie C. Neff Moo Nahm Yum 《Immunological investigations》1985,14(1):57-71
Previous studies demonstrated that prostaglandins of the E1 (PGE1) series reduced immune complex (IC) accumulation and inflammation in murine glomeruli in IC glomerulonephritis (GN). This study examines the effect of PGE1 on IC interaction with cultured rabbit glomerular cells and heparan sulfate synthesis by the cells. IC were formed with antigen chemically modified to produce a cationic (CAT) charge or left unmodified (UM). CAT IC binding to cells was greater than UM IC in the absence of PGE1. CAT IC binding to cells was increased by PGE1 while UM IC interaction was not affected. Prolonged exposure of cells to PGE1 enhanced CAT IC binding. Heparan sulfate synthesis by the cells was not affected by the concentrations of PGE1 employed. The findings suggest the benefit provided by PGE1 in murine IC GN may not be due to a direct effect on glomerular cells which reduces glomerular IC accumulation. 相似文献
98.
牛蒡子化学成分的研究 总被引:16,自引:0,他引:16
从牛蒡(Arctium lappa L.)子乙醚和丙酮提取物中,经硅胶柱层析,低压柱层析和制备性薄层层析分离到一个甾体化合物,胡萝卜甙(daucosterol,Ⅰ)和四个已知木脂素:牛蒡子甙元(arctigenin,Ⅱ)、牛蒡子甙(arctiin,Ⅲ)、罗汉松脂素(matairesinol,Ⅳ)和牛蒡酚F(lappaol F,Ⅴ)。一个新木脂素,命名为新牛蒡素乙(neoarctin B,Ⅵ)。根据光谱(UV,IR,1H-NMR,13C-NMR,DEPT,2D-NMR和MS)分析,推定了其化学结构为式Ⅵ。 相似文献
99.
A 30-year-old woman was referred for evaluation of a small nodule of the clitoris. This was subsequently diagnosed as epithelioid hemangioendothelioma. This rare vascular tumor of intermediate malignancy has not been previously described in the vulva. The patient underwent a modified radical vulvectomy and bilateral inguinal lymph node dissection, and subsequently received photon therapy. She is alive with no evidence of disease 27 months after diagnosis. 相似文献
100.