全文获取类型
收费全文 | 1315篇 |
免费 | 46篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 46篇 |
妇产科学 | 6篇 |
基础医学 | 152篇 |
口腔科学 | 9篇 |
临床医学 | 80篇 |
内科学 | 344篇 |
皮肤病学 | 71篇 |
神经病学 | 168篇 |
特种医学 | 23篇 |
外科学 | 140篇 |
综合类 | 2篇 |
预防医学 | 19篇 |
眼科学 | 76篇 |
药学 | 145篇 |
肿瘤学 | 83篇 |
出版年
2022年 | 13篇 |
2021年 | 35篇 |
2020年 | 14篇 |
2019年 | 22篇 |
2018年 | 15篇 |
2017年 | 15篇 |
2016年 | 21篇 |
2015年 | 25篇 |
2014年 | 39篇 |
2013年 | 42篇 |
2012年 | 52篇 |
2011年 | 63篇 |
2010年 | 32篇 |
2009年 | 26篇 |
2008年 | 49篇 |
2007年 | 56篇 |
2006年 | 58篇 |
2005年 | 59篇 |
2004年 | 71篇 |
2003年 | 61篇 |
2002年 | 42篇 |
2001年 | 49篇 |
2000年 | 49篇 |
1999年 | 43篇 |
1998年 | 15篇 |
1997年 | 15篇 |
1996年 | 14篇 |
1995年 | 12篇 |
1994年 | 7篇 |
1993年 | 4篇 |
1992年 | 25篇 |
1991年 | 32篇 |
1990年 | 34篇 |
1989年 | 38篇 |
1988年 | 27篇 |
1987年 | 26篇 |
1986年 | 35篇 |
1985年 | 34篇 |
1984年 | 20篇 |
1983年 | 14篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1977年 | 6篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1974年 | 4篇 |
1972年 | 7篇 |
1969年 | 8篇 |
1967年 | 3篇 |
1965年 | 4篇 |
排序方式: 共有1370条查询结果,搜索用时 0 毫秒
41.
Predictors of left ventricular remodeling in patients with acute myocardial infarction participating in cardiac rehabilitation. 总被引:9,自引:0,他引:9
Takagi Shuichi Sakuragi Satoru Baba Takeshi Takaki Hiroshi Aihara Naohiko Yasumura Yoshio Sumida Hitoshi Nonogi Hiroshi Goto Yoichi 《Circulation journal》2004,68(3):214-219
BACKGROUND: This study was designed to determine the factors influencing the development of left ventricular (LV) remodeling in patients participating in a comprehensive cardiac rehabilitation (CR) program after acute myocardial infarction (AMI), with special reference to exercise intensity and frequency. METHODS AND RESULTS: A total of 72 patients with AMI participated in CR consisting of exercise training of moderate intensity (heart rate reserve 40-60%) and education for 12 weeks. Plasma concentration of brain natriuretic peptide (BNP) was measured at the beginning and the end of CR. Echocardiography was performed before and 1 year after CR. An increase in LV end-diastolic dimension (delta-LVDd) from baseline was used as an index of remodeling. Delta-LVDd was significantly greater in patients with an anterior AMI than with other infarct locations (p<0.05) and correlated significantly with baseline BNP concentration (p<0.05). Delta-LVDd >5 mm occurred exclusively in patients with baseline BNP >150 pg/ml. Variables representing the intensity and frequency of exercise training did not correlate with delta-LVDd. CONCLUSIONS: In patients with AMI participating in CR, those having both anterior infarction and baseline BNP concentration >150 pg/ml are at high risk for subsequent LV remodeling, whereas neither exercise intensity nor participation frequency in CR appears to be associated with LV remodeling. 相似文献
42.
Yagi S Akaike M Fujimura M Ise T Yoshida S Sumitomo Y Ikeda Y Iwase T Aihara K Azuma H Kurushima A Ichikawa Y Kitagawa T Kimura T Nishiuchi T Matsumoto T 《Internal medicine (Tokyo, Japan)》2008,47(12):1113-1116
Lactobacillus (LB) is a gram-positive rod-shaped bacterium that inhabits the oral cavity, gastrointestinal tract, vagina and nasal cavity. Although LB plays a role in the prevention of infections caused by pathogenic bacteria, it causes some critical infectious diseases such as infective endocarditis (IE). IE due to LB is rare; however, early diagnosis and early treatment are important because of its high mortality rate. We report the onset of IE after otologic treatment in a heavy drinker of alcohol, the second case of IE due to LB in Japan. 相似文献
43.
Gisele Aihara HARAGUSHIKU Eduardo Donato Eing Engelke BACK Paulo Henrique TOMAZINHO Flares BARATTO FILHO Adilson Yoshio FURUSE 《Journal of applied oral science : revista FOB》2015,23(4):437-441
Objective
This study evaluated the effect of root canal disinfectants on the elimination of bacteria from the root canals, as well as their effect on glass-fiber posts bond strength.Material and Methods
Fifty-three endodontically treated root canals had post spaces of 11 mm in length prepared and contaminated with E. faecalis. For CFU/ml analysis, eight teeth were contaminated for 1 h or 30 days (n=4). Teeth were decontaminated with 5% NaOCl, 2% CHX, or distilled water. As control, no decontamination was conducted. After decontamination, sterile paper points were used to collect samples, and CFU/ml were counted. For push-out, three groups were evaluated (n=15): irrigation with 2.5% NaOCl, 2% CHX, or sterile distilled water. A bonding agent was applied to root canal dentin, and a glass-fiber post was cemented with a dual-cured cement. After 24 h, 1-mm-thick slices of the middle portion of root canals were obtained and submitted to the push-out evaluation. Three specimens of each group were evaluated in scanning electron microscopy (SEM). Data were analyzed with one-way ANOVA and Dunnett’s T3 test (α=0.05).Results
The number of CFU/ml increased from 1 h to 30 days of contamination in control and sterile distilled water groups. Decontamination with NaOCl was effective only when teeth were contaminated for 1 h. CHX was effective at both contamination times. NaOCl did not influence the bond strength (p>0.05). Higher values were observed with CHX (p<0.05). SEM showed formation of resin tags in all groups.Conclusion
CHX showed better results for the irrigation of contaminated root canals both in reducing the bacterial contamination and in improving the glass-fiber post bonding. 相似文献44.
45.
Seishi Aihara Shunsuke Yamada Satoru Shichijo Kento Fukumitsu Mika Kondo Yutaro Hirashima Hideaki Oka Taro Kamimura Atsumi Harada Toshiaki Nakano Kazuhiko Tsuruya Takanari Kitazono 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2020,24(1):34-41
Vascular access intervention therapy (VAIVT) is necessary to maintain vascular access in patients undergoing hemodialysis. VAIVT‐associated vasodilatation is painful. However, few reports have focused on effective pain relief at the time of VAIVT. The present study was performed to determine whether lidocaine‐propitocain cream, a eutectic mixture of local anesthetics (EMLA), effectively reduces VAIVT‐associated pain in patients undergoing hemodialysis. This placebo‐controlled, double‐blind, crossover study was conducted in a single center. Among 210 patients who underwent a total of 437 VAIVT procedures from August 2017 to June 2018, 30 patients were randomly allocated to either the EMLA–placebo arm or placebo–EMLA arm at the time of VAIVT. EMLA application significantly reduced the visual analog scale score compared with placebo (47.0 ± 21.1 vs. 68.6 ± 20.7 mm, respectively; P < 0.05). EMLA is a safe and effective treatment for relief of VAIVT‐associated pain in patients undergoing hemodialysis. 相似文献
46.
47.
Masanori Aihara Hiroya Fujimaki Ryosuke Shintoku Tadashi Osawa Ken Asakura Mizuho Miyazaki Tetsuyoshi Horiuchi Junpei Nitta 《Acta neurochirurgica》2013,155(4):607-609
Background
Superficial temporal artery-to-middle cerebral artery (STA-MCA) anastomosis is a common procedure for neurosurgeons. The surgery necessarily requires accurate and speedy manipulation of microscope, for which a specific training is needed. Unexpected bypass occlusion sometimes happen during surgery.Objective
Generally, conventional interrupted or continuous suture has been used for vascular anastomosis, despite various ideas have been attempted in the other surgery fields. We propose a horizontal mattress suture technique for intracranial microvascular bypass surgery. This is the first report ever published on intracranial vascular anastomosis.Methods
We had four patients of STA-MCA bypass surgery with “mattress anastomosis” from March to May of 2012.Results
During the procedure, there was no bypass occlusion and good patency was confirmed in all cases.Conclusion
Intimae of the recipient and the donor blood vessel contact each other precisely with this technique. Although a long-term assessment of patency is needed, it is useful for the intracranial bypass surgery. 相似文献48.
Aihara H Sato A Takeyasu N Nishina H Hoshi T Akiyama D Kakefuda Y Watabe H Aonuma K;for the ICAS Registry Investigators 《Catheterization and cardiovascular interventions》2012,80(4):556-563
Objectives : The aim of this study was to evaluate whether combination therapy of clopidogrel and proton pump inhibitors (PPIs) causes higher numbers of cardiovascular events than clopidogrel alone in Japanese patients. Background : PPIs are often prescribed in combination with clopidogrel following coronary stenting. PPIs are reported to diminish the effect of clopidogrel because both are metabolized by CYP2C19. However, no reports address the effects of PPIs on cardiovascular events following coronary stenting in the Japanese population. Methods : A total of 1,887 patients treated with clopidogrel following coronary stenting were enrolled in the Ibaraki Cardiac Assessment Study (ICAS) registry. All subjects were classified into two groups according to treatment without (n = 819) or with (n = 1,068) PPI. Propensity score analysis matched 1:1 according to treatment without PPI (n = 500) or with PPI (n = 500). Primary endpoint was the composite of all‐cause death or myocardial infarction. Results : No significant difference was observed in the primary endpoint between the group without PPI and the group with PPI (4.6% vs. 4.6%, P = 0.77). In contrast, a significant difference was found between the group without PPI and with PPI in regard to the incidence of gastrointestinal bleeding at the end of the follow‐up period and the specific PPI prescribed (2.4% vs. 0.8%, adjusted HR = 0.30, 95% Confidence interval 0.08‐0.87, P = 0.026) after propensity score matching. Conclusions : No significant association between PPI use and primary endpoint was observed in the Japanese population, whereas PPI use resulted in a significant reduction in the rate of gastrointestinal bleeding. © 2012 Wiley Periodicals, Inc. 相似文献
49.
Nakajima Kosuke Sakata Rei Ueda Koji Fujita Asahi Fujishiro Takashi Honjo Megumi Shirato Shiroaki Aihara Makoto 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2021,259(8):2309-2316
Graefe's Archive for Clinical and Experimental Ophthalmology - To investigate how the central visual field would be changed after fornix-based trabeculectomy with mitomycin C in Japanese... 相似文献