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51.
Ye Ri Yoon Jiyoun Choi Sang Mi Lee Yeo Joo Kim Hyun Deuk Cho Jeong Won Lee Youn Soo Jeon 《Nuclear Medicine and Molecular Imaging》2015,49(1):69-72
A follow-up 18F-fluorodeoxyglucose (18F-FDG) PET/CT scan of a 57-year-old asymptomatic male who had undergone total thyroidectomy for thyroid cancer revealed a 5.0 × 4.0-cm, well-defined, ovoid-shaped mass around the left adrenal gland without definite FDG uptake. On the adrenal CT scan, the left paraadrenal tumor showed high attenuation on the precontrast scan without enhancement. The average Hounsfield unit (HU) was 58.1 on the precontrast scan and 58.4 on the postcontrast scan. The patient underwent laparoscopic adrenalectomy for resection of the left paraadrenal tumor. The final histopathologic examination revealed a bronchogenic cyst. Although retroperitoneal bronchogenic cysts are rare, they should be considered in the differential diagnosis of retroperitoneal cystic tumors. The preoperative diagnosis is difficult, but a contrast-enhanced CT scan or 18F-FDG PET/CT scan may be useful for differentiating hyperattenuated cysts from other soft tissue masses. 相似文献
52.
Youn TJ Piao H Kwon JS Choi SY Kim HS Park DG Kim DW Kim YG Cho MC 《European journal of heart failure》2002,4(6):713-718
BACKGROUND: The calcineurin-mediated signaling pathway has been implicated as one of the crucial pathways in cardiac hypertrophy. However, the role of calcineurin pathway on cardiac remodeling after myocardial infarction (MI) has not been well defined. METHODS: Infarcted rats (n = 45) were randomized into calcineurin inhibitor, cyclosporin A (CsA) or vehicle groups, 3 days after MI and treated for 2 weeks (early post-MI cardiac remodeling stage), or randomized 17 days after MI and treated for 2 weeks (late remodeling stage). RESULTS: Calcineurin pathway inhibition during the early cardiac remodeling stage attenuated the myocardial hypertrophy after MI (P < 0.05). However, left ventricular dimensions were further increased and fractional shortening deteriorated with calcineurin inhibition during this stage (P < 0.05, each). During late remodeling stage, CsA treatment did not affect myocardial hypertrophy and cardiac dilation following MI. CONCLUSION: Our results strongly support the hypothesis that calcineurin pathway mediates compensatory myocardial hypertrophy during the early remodeling stage after MI. However, the calcineurin pathway does not seem to affect the late remodeling after MI. 相似文献
53.
Duk Youn Cho Si-Woon Park Min Jin Lee Dae Sung Park Eun Joo Kim 《Journal of Physical Therapy Science》2015,27(10):3053-3057
[Purpose] The purpose of this study was to confirm the effect of robot-assisted gait
training on the balance and gait ability of stroke patients who were dependent ambulators.
[Subjects and Methods] Twenty stroke patients participated in this study. The participants
were allocated to either group 1, which received robot-assisted gait training for 4 weeks
followed by conventional physical therapy for 4 weeks, or group 2, which received the same
treatments in the reverse order. Robot-assisted gait training was conducted for 30 min, 3
times a week for 4 weeks. The Berg Balance Scale, Modified Functional Reach Test,
Functional Ambulation Category, Modified Ashworth Scale, Fugl-Meyer Assessment, Motricity
Index, and Modified Barthel Index were assessed before and after treatment. To confirm the
characteristics of patients who showed a significant increase in Berg Balance Scale after
robot-assisted gait training as compared with physical therapy, subgroup analysis was
conducted. [Results] Only lateral reaching and the Functional Ambulation Category were
significantly increased following robot-assisted gait training. Subscale analyses
identified 3 patient subgroups that responded well to robot-assisted gait training: a
subgroup with hemiplegia, a subgroup in which the guidance force needed to be decreased to
needed to be decreased to ≤45%, and a subgroup in which weight bearing was decreased to
≤21%. [Conclusion] The present study showed that robot-assisted gait training is not only
effective in improving balance and gait performance but also improves trunk balance and
motor skills required by high-severity stroke patients to perform activities daily living.
Moreover, subscale analyses identified subgroups that responded well to robot-assisted
gait training.Key words: Stroke, Robotics, Gait 相似文献
54.
Follicular variant of papillary thyroid carcinoma with B‐type RafV600E showing higher frequency of suspicious sonographic features and multifocality 下载免费PDF全文
55.
Inhibition of myeloid cell leukemia‐1: Association with sorafenib‐induced apoptosis in human mucoepidermoid carcinoma cells and tumor xenograft 下载免费PDF全文
56.
Youn Moo Heo Jin Woong Yi Jung Bum Lee Dae Hee Lee Won Keun Park Sun Joong Kim 《Clinics in Orthopedic Surgery》2015,7(2):241-247
Background
Unstable simple elbow dislocation (USED) repair is challenged by the maintenance of joint reduction; hence, primary repair or reconstruction of disrupted ligaments is required to maintain the congruency and allow early motion of the elbow. We evaluated the effectiveness and the outcome of lateral collateral ligament (LCL) complex repair with additional medial collateral ligament (MCL) repair in cases of USED.Methods
We retrospectively reviewed 21 cases of diagnosed USED without fractures around the elbow that were treated with primary ligament repair. In all cases, anatomical repair of LCL complex with or without common extensor origin was performed using suture anchor and the bone tunnel method. Next, the instability and congruency of elbow for a full range of motion were evaluated under the image intensifier. MCL was repaired only if unstable or incongruent elbow was observed. Clinical outcomes were evaluated using the Mayo elbow performance score (MEPS) and radiographic outcomes on last follow-up images.Results
All cases achieved a stable elbow on radiographic and clinical results. LCL complex repair alone was sufficient to obtain the stable elbow in 17 of 21 cases. Four cases required additional MCL repair after restoration of the LCL complex. The overall mean MEPS was 91 (range, 70 to 100): excellent in 12 cases, good in 7 cases, and fair in 2 cases. All 17 cases with LCL complex repair only and 2 of 4 cases with additional MCL repair had excellent or good results by MEPS.Conclusions
USED requires surgical treatment to achieve a congruent and stable joint. If the repair of lateral stabilizer such as LCL complex acquires enough joint stability to maintain a full range of motion, it may not be necessary to repair the medial stabilizer in all cases of USED. 相似文献57.
Park YJ Lee YJ Kim SH Joung DS Kim BJ So I Park do J Cho BY 《Molecular and cellular endocrinology》2008,285(1-2):19-25
Ghrelin regulates cell proliferation through the growth hormone secretagogue receptor (GHS-R). We confirmed the expression of GHS-R in FRTL-5 thyroid cells and investigated the effects of ghrelin in thyrocytes using FRTL-5 cells. Ghrelin increased intracellular calcium levels but not intracellular cyclic AMP levels. Ghrelin activated Erk within 2min, then activated Akt and STAT3. Erk phosphorylation was inhibited by the calcium inhibitor cyclopiazonic acid (CPA). Ghrelin alone did not stimulate FRTL-5 cell proliferation but enhanced the effects of thyroid stimulating hormone (TSH). Pretreatment with TSH potentiates the growth effects of ghrelin in thyroid cells, and p66Shc, a growth factor receptor adaptor protein, might mediate these synergistic effects. Ghrelin phosphorylated TSH-induced p66Shc, which was inhibited by CPA. Ghrelin did not affect the proliferation of ARO cells, which showed no increased expression of p66Shc after TSH treatment. Thus, ghrelin-induced intracellular calcium signaling enhanced the TSH-induced proliferation of thyrocytes, possibly mediated by the p66Shc pathway. 相似文献
58.
Joo An Hwang Kee Bum Kim Min Jae Yang Sun Gyo Lim Jae Chul Hwang Jae Youn Cheong Sung Won Cho Soon Sun Kim 《Clinical and molecular hepatology》2015,21(2):131-140
Background/Aims
To determine the efficacies of entecavir (ETV) in nucleos(t)ide analogue (NA)-naïve chronic hepatitis B (CHB) patients and in those with prior lamivudine (LAM) use who did not develop resistance.Methods
We retrospectively enrolled 337 patients with CHB who were treated with ETV (0.5 mg daily) for at least 30 months. The study included 270 (80.1%) NA-naïve patients and 67 (19.9%) LAM-use patients. Ten of the LAM-use patients were refractory to LAM therapy without developing resistance.Results
Genotypic resistance to ETV developed more frequently in the LAM-use group (13.1%) than in the NA-naïve group (2.6%) at 60 months (P=0.009). In subgroup analysis, after excluding the 10 patients who were refractory to LAM therapy, the cumulative probability of ETV resistance did not differ significantly between the two groups (P=0.149). Prior LAM refractoriness and a higher hepatitis B virus DNA level at month 12 were independent predictive factors for the development of ETV resistance.Conclusions
ETV resistance developed more frequently in LAM-use patients with CHB. However, prior LAM use without refractoriness did not affect the development of ETV resistance. The serum hepatitis B virus DNA level at month 12 was a major predictor for the development of ETV resistance. 相似文献59.
Song-I Yang Byoung-Ju Kim So-Yeon Lee Hyo-Bin Kim Cheol Min Lee Jinho Yu Mi-Jin Kang Ho-Sung Yu Eun Lee Young-Ho Jung Hyung Young Kim Ju-Hee Seo Ji-Won Kwon Dae Jin Song GwangCheon Jang Woo-Kyung Kim Jung Yeon Shim Soo-Young Lee Hyeon Jong Yang Dong In Suh Seo Ah Hong Kil-Yong Choi Youn Ho Shin Kangmo Ahn Kyung Won Kim Eun-Jin Kim Soo-Jong Hong COCOA Study Group 《Allergy, asthma & immunology research》2015,7(6):573-582
Purpose
To investigate whether prenatal exposure to indoor fine particulate matter (PM2.5) and environmental tobacco smoke (ETS) affects susceptibility to respiratory tract infections (RTIs) in infancy, to compare their effects between prenatal and postnatal exposure, and to determine whether genetic factors modify these environmental effects.Methods
The study population consisted of 307 birth cohort infants. A diagnosis of RTIs was based on parental report of a physician''s diagnosis. Indoor PM2.5 and ETS levels were measured during pregnancy and infancy. TaqMan was used for genotyping of nuclear factor erythroid 2-related factor (Nrf2) (rs6726395), glutathione-S-transferase-pi (GSTP) 1 (rs1695), and glutathione-S-transferase-mu (GSTM) 1. Microarrays were used for genome-wide methylation analysis.Results
Prenatal exposure to indoor PM2.5 increased the susceptibility of lower RTIs (LRTIs) in infancy (adjusted odds ratio [aOR]=2.11). In terms of combined exposure to both indoor PM2.5 and ETS, prenatal exposure to both pollutants increased susceptibility to LRTIs (aOR=6.56); however, this association was not found for postnatal exposure. The Nrf2 GG (aOR=23.69), GSTM1 null (aOR=8.18), and GSTP1 AG or GG (aOR=7.37) genotypes increased the combined LRTIs-promoting effects of prenatal exposure to the 2 indoor pollutants. Such effects of prenatal indoor PM2.5 and ETS exposure were not found for upper RTIs.Conclusions
Prenatal exposure to both indoor PM2.5 and ETS may increase susceptibility to LRTIs. This effect can be modified by polymorphisms in reactive oxygen species-related genes. 相似文献60.
Acceleration of Bone Regeneration by BMP‐2‐Loaded Collagenated Biphasic Calcium Phosphate in Rabbit Sinus 下载免费PDF全文