全文获取类型
收费全文 | 306481篇 |
免费 | 14428篇 |
国内免费 | 9167篇 |
专业分类
耳鼻咽喉 | 2136篇 |
儿科学 | 8434篇 |
妇产科学 | 4380篇 |
基础医学 | 28599篇 |
口腔科学 | 4097篇 |
临床医学 | 30993篇 |
内科学 | 46347篇 |
皮肤病学 | 2275篇 |
神经病学 | 20930篇 |
特种医学 | 13419篇 |
外国民族医学 | 44篇 |
外科学 | 38861篇 |
综合类 | 31477篇 |
现状与发展 | 40篇 |
一般理论 | 8篇 |
预防医学 | 30680篇 |
眼科学 | 6340篇 |
药学 | 24706篇 |
234篇 | |
中国医学 | 11320篇 |
肿瘤学 | 24756篇 |
出版年
2024年 | 541篇 |
2023年 | 2066篇 |
2022年 | 5223篇 |
2021年 | 6545篇 |
2020年 | 5383篇 |
2019年 | 3985篇 |
2018年 | 25712篇 |
2017年 | 21685篇 |
2016年 | 23109篇 |
2015年 | 7183篇 |
2014年 | 8505篇 |
2013年 | 8681篇 |
2012年 | 18725篇 |
2011年 | 33309篇 |
2010年 | 28258篇 |
2009年 | 19426篇 |
2008年 | 28142篇 |
2007年 | 30011篇 |
2006年 | 7959篇 |
2005年 | 8737篇 |
2004年 | 7717篇 |
2003年 | 8346篇 |
2002年 | 5757篇 |
2001年 | 2854篇 |
2000年 | 2579篇 |
1999年 | 1824篇 |
1998年 | 1161篇 |
1997年 | 1195篇 |
1996年 | 833篇 |
1995年 | 729篇 |
1994年 | 683篇 |
1993年 | 397篇 |
1992年 | 354篇 |
1991年 | 385篇 |
1990年 | 388篇 |
1989年 | 282篇 |
1988年 | 252篇 |
1987年 | 217篇 |
1986年 | 137篇 |
1985年 | 118篇 |
1984年 | 64篇 |
1983年 | 62篇 |
1982年 | 39篇 |
1980年 | 46篇 |
1938年 | 60篇 |
1937年 | 25篇 |
1935年 | 22篇 |
1934年 | 30篇 |
1932年 | 56篇 |
1930年 | 46篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
102.
103.
李松林副主任医师将肾小球肾炎的病机概括为湿、热、毒、瘀、虚等方面,在中医辨证的基础上,结合现代医学对其病因和发病机理的认识及中草药药理作用,针对不同的病理机制和临床表现,提出清热解毒法,活血化瘀法,调补脾肾法,扶正固本法,并视症有机结合,恰当治疗,疗效显著。 相似文献
104.
淋巴瘤样肉芽肿与韦格内肉芽肿临床特点的比较 总被引:2,自引:0,他引:2
目的 总结淋巴瘤样肉芽肿病(lym phom atoid granulom atosis,LG)与韦格内肉芽肿( egener granulo Wm atosis,W G)的临床特点,从临床上加以鉴别。 方法 回顾性总结我院与北京协和医院 1989 年以来收治的 6 例 LG和20 例 W G 患者的临床资料,并进行比较。 结果 发热、咳嗽及呼吸困难在 LG 中较常见,流涕、鼻衄及关节痛以W G 为多,肺受累以 LG 为多,耳鼻喉、眼及肾病变在 W G 中明显增多,皮肤受损两者相似。W G 患者常有 c-ANCA 阳性及尿沉渣异常。 LG X 线胸片为双侧多发结节,边界不清,多无肺门、纵隔淋巴结肿大; G 则为双侧多发边界清晰W的结节, 易形成空洞, 肺门和纵隔淋巴结可肿大。LG 病理改变为血管中心性淋巴增生性病变, 浸润的细胞主要是小淋巴细胞和不同数量大的不典型淋巴细胞; 而在 W G 中可见坏死性血管炎及大量中性白细胞、浆细胞及少量嗜酸细胞浸润形成的肉芽肿, 部分有多核巨细胞。W G 经治疗后, 多数患者病情缓解; 则疗效不佳。 结论 LG 和 W G 在临 LG床表现、实验室检查、 影像及病理诸方面的差异有利于两者的鉴别诊断。 相似文献
105.
本文将我科1974年至1983年收治的148例口腔颌面部恶性肿瘤就性别、年龄、发病部位、肿瘤性质以及所随访的102例口腔领面部恶肿瘤的存活率与肿瘤性质、部位、治疗等的关系进行了统计分析,并评价了冷冻治疗及颈淋巴结根治术。同时阐明了唇癌、皮肤癌淋巴结根治术的指征。 相似文献
106.
Zhang Gu-sheng章谷生 Hu Fang-yuan胡方远 Ye Qing-zhen叶庆祯 Yan Yong-tang严咏棠Immunology Laboratory Shanghai Institute of Biologicat Products Shanghai 《中华医学杂志(英文版)》1986,99(4):343-346
Neurotropin (NSP) is an extract isolated from
the skin of rabbits inoculated with vaccinia virus.
The present study examines the possible action of
NSP on the number and function of immunocompe
tent cells in mice. The experiment showed that NSP
had no effect on both T and B lymphocytes of nor-
malimmunized mouse spleen. The degree of plaque
forming cell reaction and titre of specific antibody
showed no significant differences when the NSP
treated group and controls were compared. How-
ever, NSP exhibited promotive effect on specific
antigen binding cells in the early stage of immune
responses. It was also noted that the rosette forming
capacity of human T lymphocytes in vitro was restor-
ed markedly by NSP. These results suggest that
NSP possesses certain immunostimulating activity,
particularly on the specific antigen binding cells and
human T lymphocytes. 相似文献
107.
Expression of Anion Exchanger 1 Sequestrates p16 in the Cytoplasm in Gastric and Colonic Adenocarcinoma 下载免费PDF全文
Wei-Wei Shen Jun Wu Li Cai Bing-Ya Liu Yan Gao Guo-Qiang Chen Guo-Hui Fu 《Neoplasia (New York, N.Y.)》2007,9(10):812-819
p16INK4A (p16) binds to cyclin-dependent kinase 4/6 and negatively regulates cell growth. Recent studies have led to an understanding of additional biologic functions for p16; however, the detailed mechanisms involved are still elusive. In this article, we show an unexpected expression of anion exchanger 1 (AE1) in the cytoplasm in poorly and moderately differentiated gastric and colonic adenocarcinoma cells and in its interaction with p16, thereby sequestrating the protein in the cytoplasm. Genetic alterations of p16 and AE1 were not detectable. Forced expression of AE1 in these cells sequestrated more p16 in the cytoplasm, whereas small interfering RNA-mediated silencing of AE1 in the cells induced the release of p16 from the cytoplasm to the nucleus, leading to cell death and growth inhibition of tumor cells. By analyzing tissue samples obtained from patients with gastric and colonic cancers, we found that 83.33% of gastric cancers and 56.52% of colonic cancers coexpressed AE1 and p16 in the cytoplasm. We conclude that AE1 plays a crucial role in the pathogenesis of gastric and colonic adenocarcinoma and that p16 dysfunction is a novel pathway of carcinogenesis. 相似文献
108.
109.
110.
Chad G. Ball Andrew W. Kirkpatrick Matthew Smith Robert H. Mulloy Leonard Tse Ian B. Anderson 《European journal of trauma and emergency surgery》2007,33(5):550-552
Abstract We report a case of SMV injury in a critically ill patient. The patient was a 19-year-old woman involved in a motor vehicle
collision. Her injuries included grade II splenic and renal lacerations, devascularized and lacerated right and transverse
colon, a transected transverse mesocolon, a massive shear injury of her abdominal wall, and two partial SMV transections.
At initial damage control laparotomy, the SMV was ligated, the devascularized bowel resected and a temporary abdominal closure
applied. At re-operation, a mesocaval shunt using saphenous vein was employed. The shunt failed and the patient required a
saphenous vein jump graft. Although visceral vascular injuries are rare, ligation of the SMV in a damage control situation
is acceptable. This case study is the first to discuss appropriate treatment when interruption to a patient's collateral visceral
venous drainage limits the surgeon’s ability to ligate. In these situations, bypass shunts may be successful. 相似文献