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991.
Murakami K Sasaki S Takahashi Y Uenishi K;Japan Dietetic Students' Study for Nutrition Biomarkers Group 《The British journal of nutrition》2008,100(3):642-651
Mild metabolic acidosis, which can be caused by diet, may adversely affect cardiometabolic risk factors, possibly by increasing cortisol production. Methodologies for estimating diet-induced acid-base load using dietary-intake information have been established. To our knowledge, however, the possible association between dietary acid-base load and cardiometabolic risk factors has not been investigated. We cross-sectionally examined associations between dietary acid-base load and cardiometabolic risk factors in a free-living population. The subjects were 1136 female Japanese dietetic students aged 18-22 years. Dietary acid-base load was characterized as the potential renal acid load (PRAL), which was determined using an algorithm including dietary protein, P, K, Ca and Mg, as well as the ratio of dietary protein to K (Pro:K). Estimates of each nutrient were obtained from a validated comprehensive self-administered diet history questionnaire. Body height and weight, waist circumference and blood pressure were measured. Fasting blood samples were collected. After adjustment for potential confounding factors, higher PRAL and Pro:K (more acidic dietary acid-base loads) were associated with higher systolic and diastolic blood pressure (P for trend = 0.028 and 0.035 for PRAL and 0.012 and 0.009 for Pro:K, respectively). PRAL was also independently positively associated with total and LDL-cholesterol (n 1121; P for trend = 0.042 and 0.021, respectively). Additionally, Pro:K showed an independent positive association with BMI and waist circumference (P for trend = 0.024 and 0.012, respectively). In conclusion, more acidic dietary acid-base load was independently associated with adverse profile of several cardiometabolic risk factors in free-living young Japanese women. 相似文献
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993.
Yoshiko Kagimoto Kenshi Yamasaki Ryoko Shimada‐Ohmori Liu Nan Yukikazu Numata Setsuya Aiba 《The Journal of dermatology》2017,44(6):690-694
Cutaneous leiomyomas are benign smooth muscle tumors that are occasionally painful. The mechanism of pain related to leiomyoma is not fully understood. To investigate the possible involvement of algoneic factors in pain from cutaneous leiomyomas. We present a case of cutaneous leiomyoma with severe, diffused pain in a large area and collected 10 more specimens of cutaneous leiomyoma with or without pain in patient histories. We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE2, BDKRB2, VR1 and CGRP. We compared the pain area and expression of algoneic factors to reveal possible correlations. We describe here a patient with a cutaneous leiomyoma 1‐cm in diameter, which caused severe pain diffused throughout an area of 20‐cm around the tumor. The pain completely resolved after surgical excision of the leiomyoma. We observed that the leiomyoma cells expressed CGRP, PGE2 and VR1 in this case. We found a positive correlation between VR1 and PGE2 expression in the leiomyoma cells and areas with pain around the tumors among 11 specimens in total. VR1 and PGE2 might be key algogenic substances in painful leiomyoma. 相似文献
994.
Cortical neurons are known to be noisy encoders of information, showing large response variabilities with repeated presentations of identical stimuli. These spike count variabilities are correlated over the cell population and their neuronal mechanism and functional significance have not been well understood. Recently there has been much debate over the magnitude of the population mean of the correlation, ranging from 0.1 to 0.2 down to nearly zero. We performed multi‐neuron recordings on the cat visual cortex and found that the population mean did not necessarily represent the nature of correlated variabilities because the spike count correlation showed significant diversity and heterogeneity. Although the population mean was relatively small (0.06), the correlations of individual unit pairs were distributed over a broad range, extending to both positive and negative values. In most of the recording sessions of local cell populations (83%), significantly positive correlations coexisted with significantly negative ones in different unit pairs. Furthermore, nearly 20% of the unit pairs showed significant variation in the spike count correlation for different stimulus orientations. Correlation analysis between the spike count correlation and the firing activity of the unit pair suggested that the orientation tuning properties of the two quantities were unlikely to have originated from a common neuronal mechanism. Diversity, heterogeneity and context‐dependent variation suggests that the correlated spike count variabilities originate not from fixed anatomical connections but rather from the dynamic interaction of neuronal networks. 相似文献
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998.
Angiogenesis as a predictor of long-term survival for 377 Japanese patients with breast cancer 总被引:3,自引:2,他引:3
Takao Kato Shingo Kameoka Tsunehito Kimura Naohiro Soga Yutaka Abe Toshio Nishikawa Makio Kobayashi 《Breast cancer research and treatment》2001,70(1):65-74
Angiogenesis, as assessed by microvessels, has been a common prognostic indicator for breast cancer in the last decade. However, the significance of angiogenesis remains controversial. This is a retrospective study of 377 Japanese patients selected from 663 breast cancer patients operated on between 1971 and 1987. To evaluate an objective method to quantify microvessel density in angiogenesis, we employed average microvessel count (AMC) per square millimeter. We investigated five factors: angiogenesis, lymph-node status (n), clinical tumor size (T), histological grade (HG), and tumor necrosis (TN), followed for a median of 10 years. Sixty-seven patients (17.8%) had recurrence and 54 patients (14.3%) died of breast cancer. Univariate analysis showed that n, T, HG, and AMC (P=0.0020) were significantly predictive of 20-year relapse-free survival (RFS). n, T, and HG were significantly associated with 20-year overall survival (OS) but AMC was borderline significant (P=0.0630). Multivariate analysis for RFS and OS showed that n, T, HG, and AMC (P<0.0001, P=0.0033, respectively) were all significant and independent prognostic factors. When stratified by T or n, a significant impact of AMC on RFS or OS was seen both in patients with T2 and T3 carcinomas or in node-negative patients, but not in T1 or node-positive patients. Thus, we can confirm angiogenesis as a significant independent prognostic factor associated with long-term survival in Japanese breast cancer patients, especially in node-negative patients and in patients with T2 and T3 carcinomas. 相似文献
999.
Takaaki Konuma Yoshimitsu Shimomura Yukiyasu Ozawa Yasunori Ueda Naoyuki Uchida Makoto Onizuka Megumi Akiyama Takehiko Mori Hirohisa Nakamae Yuju Ohno Souichi Shiratori Yasushi Onishi Yoshinobu Kanda Takahiro Fukuda Yoshiko Atsuta Ken Ishiyama 《Hematological oncology》2019,37(1):85-95
To reduce post‐transplant relapse, acute myeloid leukemia (AML) type remission induction chemotherapy has been attempted to reduce disease burden before allogeneic hematopoietic cell transplantation (HCT) in patients with advanced myelodysplastic syndrome (MDS). However, the efficacy of induction chemotherapy before HCT is unclear. We retrospectively analyzed the Japanese registration data of 605 adult patients, who had received allogeneic HCT for advanced MDS between 2001 and 2016, to compare the post‐transplant relapse between patients who received induction chemotherapy followed by allogeneic HCT and those who received upfront HCT. Propensity score matching identified 230 patients from each cohort. There were no significant differences in overall survival and non‐relapse mortality between the two groups. The cumulative incidence of relapse was significantly higher in patients who received induction chemotherapy than those who received upfront HCT. In the subgroup analyses, upfront HCT had a significantly reduced relapse incidence among patients with poor cytogenetics, those with higher international prognostic scoring system at diagnosis, and those who received reduced‐intensity conditioning. Our results suggested that AML type remission induction chemotherapy before HCT did not improve post‐transplant relapse and survival for adult patients with advanced MDS. Upfront HCT is preferable for patients with a poor karyotype. 相似文献
1000.
Kazuhiro Kitajima Yuko Suenaga Yoshiko Ueno Tomonori Kanda Tetsuo Maeda Satoru Takahashi Yasuhiko Ebina Yoshiya Miyahara Hideto Yamada Kazuro Sugimura 《European journal of radiology》2013