全文获取类型
收费全文 | 5136篇 |
免费 | 260篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 162篇 |
妇产科学 | 33篇 |
基础医学 | 595篇 |
口腔科学 | 88篇 |
临床医学 | 327篇 |
内科学 | 1384篇 |
皮肤病学 | 36篇 |
神经病学 | 327篇 |
特种医学 | 203篇 |
外科学 | 1169篇 |
综合类 | 10篇 |
预防医学 | 133篇 |
眼科学 | 67篇 |
药学 | 260篇 |
中国医学 | 9篇 |
肿瘤学 | 606篇 |
出版年
2023年 | 36篇 |
2022年 | 73篇 |
2021年 | 126篇 |
2020年 | 74篇 |
2019年 | 93篇 |
2018年 | 144篇 |
2017年 | 91篇 |
2016年 | 130篇 |
2015年 | 103篇 |
2014年 | 145篇 |
2013年 | 174篇 |
2012年 | 265篇 |
2011年 | 287篇 |
2010年 | 213篇 |
2009年 | 171篇 |
2008年 | 257篇 |
2007年 | 305篇 |
2006年 | 288篇 |
2005年 | 249篇 |
2004年 | 303篇 |
2003年 | 288篇 |
2002年 | 289篇 |
2001年 | 116篇 |
2000年 | 116篇 |
1999年 | 105篇 |
1998年 | 71篇 |
1997年 | 52篇 |
1996年 | 53篇 |
1995年 | 44篇 |
1994年 | 51篇 |
1993年 | 39篇 |
1992年 | 64篇 |
1991年 | 74篇 |
1990年 | 66篇 |
1989年 | 59篇 |
1988年 | 41篇 |
1987年 | 49篇 |
1986年 | 50篇 |
1985年 | 31篇 |
1984年 | 39篇 |
1983年 | 28篇 |
1982年 | 22篇 |
1981年 | 16篇 |
1980年 | 13篇 |
1979年 | 19篇 |
1978年 | 15篇 |
1977年 | 11篇 |
1976年 | 12篇 |
1975年 | 10篇 |
1973年 | 8篇 |
排序方式: 共有5433条查询结果,搜索用时 0 毫秒
21.
22.
Koichi Akamatsu Soichiro Miyauchi Kenji Ohshima Shunji Okita Yoshifumi Yasuhara Hiroshi Mogami Yasuyuki Ohta Ken Hamamoto 《Cancer chemotherapy and pharmacology》1989,23(Z1):S59-S64
Transcatheter arterial embolization (TAE) with the concurrent use of caerulein was assessed for the purpose of preventing gallbladder complications often seen after TAE of hepatic carcinoma. Ninety-six cases with primary hepatic carcinoma, who had undergone TAE in the right hepatic arterial region over the past 4 years, were divided into three groups: 22 cases for which embolization was possible on a selective basis by passing the catheter to the peripheral side beyond the bifurcated region of the cystic artery; 40 cases who had undergone TAE in which caerulein was not administered, from the central side of the bifurcated region of the cystic artery; and 34 cases given 20 g caerulein 15–30 min before TAE. A comparison was made using the abdominal pain, pyrexia, rate of leukocytosis and the US findings of the gallbladder as the indices of the gallbladder complications. As a result, it become evident that it was possible to prevent or alleviate gallbladder complications if caerulein were administered before TAE in cases where the embolizing substances were infused in the right hepatic artery from the central side of the bifurcated region of the cystic artery. It was conclusively shown that the gallbladder blood flow decreases if the organ is contracted by caerulein, which in turn causes a decrease in the inflow of the embolizing substances whereby complications are alleviated. 相似文献
23.
24.
25.
Suzuki T Muraki Y Yasukochi T Zhang H Kori Y Wakamatsu E Hayashi T Goto D Ito S Tsutsumi A Sumichika H Sumida T Matsumoto I 《Autoimmunity reviews》2005,4(7):475-478
Anti-glucose-6-phosphate isomerase (GPI) antibodies (Abs) solely induce arthritis in mice. High titers of anti-GPI Abs are found in some patients with rheumatoid arthritis (RA), but their pathogenic role remains elusive. The aim of this study was to evaluate the pathogenic role of anti-GPI Abs in cynomolgus monkeys. IgG fractions were separated from sera of anti-GPI Abs-positive RA patients and healthy subjects and directly injected into the metacarpophalangeal joints of 4 cynomolgus monkeys. At day 16, the joints were harvested and examined histologically and immunohistochemically. The expression of C5a receptor (C5aR) molecule in the synovium was quantified by real-time PCR using cDNA from monkey joints. In monkey joints, IgG including anti-GPI Abs resulted in recruitment of granulocytes and mononuclear cells, strong deposition of human IgG on the articular surface, and overexpression of C5aR, but no joint swelling. No infiltrated cells or IgG deposition were observed in monkeys injected with IgGs from healthy subjects. Our results suggest that IgG fraction from RA patients including anti-GPI Abs may play a crucial role in the generation of synovitis in monkeys, although the pathogenesis of anti-GPI Abs in RA patients is still uncertain. 相似文献
26.
Shirai M Shimouchi A Ikeda S Oya H Min KY Kawaguchi AT Mori H Ninomiya I 《The Japanese journal of physiology》2001,51(3):395-398
We measured internal diameter (ID) changes in resistance and conduit pulmonary arteries of 1- and 2-week hypoxic rats and normoxic control rats in response to nitric oxide synthase (NOS) inhibitors in vivo. At 2 weeks of hypoxic exposure, the ID reduction as a result of NOS inhibition was enhanced within the resistance arteries, but not at 1 week of hypoxia. 相似文献
27.
28.
Suguru Yonezawa Yoshifumi Matsushita Hisako Muramatsu Yuko Arita Takao Nakamura Takashi Muramatsu Eiichi Sato 《Pathology international》1987,37(8):1249-1261
Using the surgically extirpated specimens from 9 patients with colorectal carcinoma, fucosyltransferase activities in the carcinoma tissue and the normal mucosa were measured and were compared with the hlstochemical findings of glycoconjugates which were shown by staining with lectins reacting with blood group antigens and related substances. The fucosyltransferase activities of the carcinoma tissue were well correlated with the overall findings of lectin stainings after neuraminidase treatment. The more intense the carcinoma tissue was stained, the higher the fucosyltransferase activity was shown. However, there were marked differences in the fucosyltransferase activities by the portions measured, depending upon the relative amount of carcinoma tissue and Interstitial tissue; in the invasive portion with less carcinoma tissue, the activity was generally low in comparison with that in the surface area where carcinoma tissue was rather abundant. Thus, the morphological and lectin hlstochemical finding are of paramount importance for the eveluation of glycosyltransferase activity in human colorectal carcinoma. 相似文献
29.
Kuniaki Tanaka Yoshifumi Tomita Mari Tsuruta Fumiko Konishi Masao Okuda Kunisuke Himeno Kikuo Nomoto 《Immunopharmacology and immunotoxicology》1990,12(2):277-291
Chlorella vulgaris, an unicellular green algae, or its acetone-extract (Ac-Ex) were administered orally to Meth A tumor bearing BALB/c or (BALB/c DBA/2)F1 (CDF1) mice. When CDF1 mice were fed daily with 10% dried powder of Chlorella vulgaris (CVP) containing diet before and after Meth A tumor inoculation, the growth of rechallenged Meth A tumor was significantly suppressed in an antigen-specific manner. Augmentation of antitumor resistance was exhibited also by Winn assay using lymph node cells of tumor-bearing mice orally administered with CVP or Ac-Ex. Antigen-specific concomitant immunity in these mice were mediated by cytostatic T cells but not by cytotoxic T cells. Natural killer cells seemed not to contribute in antitumor resistance in this system. 相似文献
30.
Murakami T Ohtsuka A Matsuoka H Taguchi T Murakami T Abe K Ninomiya Y 《Archives of histology and cytology》2001,64(1):45-50
Ferric chloride, when boiled with ammonium thiocyanate, ammonia and cacodylic acid, is converted into a fine anionic iron colloid which consists of 1.0-1.5 nm electron dense granules and gives a distinct Prussian blue reaction (OHTSUKA and MURAKAMI, 1986). Light microscopy of tissue sections stained with this fine anionic iron colloid at pH values of 6.0, 7.0 and 8.0 showed that the healthy adult rat brain contains a considerable number of neurons which possess an intensely positively charged perineuronal net. This net was most clearly demonstrable by staining with the anionic iron colloid at a pH value of 8.0, at which ionizations of almost all cationic sites of the tissue elements were obliterated. Transmission electron microscopy of ultrathin sections stained at a pH value of 8.0 showed that the anionic iron colloid was preferentially deposited in the perineuronal tissue spaces. These findings indicate that the intensely positively charged perineuronal net contains some strongly basic substances such as guanidino compounds, and occupies the perineuronal (perisynaptic) tissue space. 相似文献