全文获取类型
收费全文 | 7279篇 |
免费 | 498篇 |
国内免费 | 43篇 |
专业分类
耳鼻咽喉 | 63篇 |
儿科学 | 173篇 |
妇产科学 | 105篇 |
基础医学 | 1087篇 |
口腔科学 | 124篇 |
临床医学 | 516篇 |
内科学 | 1589篇 |
皮肤病学 | 391篇 |
神经病学 | 525篇 |
特种医学 | 314篇 |
外科学 | 1181篇 |
综合类 | 162篇 |
一般理论 | 4篇 |
预防医学 | 365篇 |
眼科学 | 263篇 |
药学 | 327篇 |
中国医学 | 28篇 |
肿瘤学 | 603篇 |
出版年
2024年 | 11篇 |
2023年 | 62篇 |
2022年 | 113篇 |
2021年 | 204篇 |
2020年 | 137篇 |
2019年 | 175篇 |
2018年 | 195篇 |
2017年 | 167篇 |
2016年 | 218篇 |
2015年 | 235篇 |
2014年 | 332篇 |
2013年 | 304篇 |
2012年 | 555篇 |
2011年 | 515篇 |
2010年 | 284篇 |
2009年 | 263篇 |
2008年 | 388篇 |
2007年 | 367篇 |
2006年 | 336篇 |
2005年 | 390篇 |
2004年 | 330篇 |
2003年 | 270篇 |
2002年 | 303篇 |
2001年 | 236篇 |
2000年 | 224篇 |
1999年 | 180篇 |
1998年 | 68篇 |
1997年 | 49篇 |
1996年 | 48篇 |
1995年 | 47篇 |
1994年 | 38篇 |
1993年 | 25篇 |
1992年 | 78篇 |
1991年 | 76篇 |
1990年 | 71篇 |
1989年 | 80篇 |
1988年 | 91篇 |
1987年 | 64篇 |
1986年 | 50篇 |
1985年 | 44篇 |
1984年 | 35篇 |
1983年 | 39篇 |
1982年 | 7篇 |
1981年 | 10篇 |
1980年 | 6篇 |
1979年 | 24篇 |
1978年 | 10篇 |
1977年 | 16篇 |
1974年 | 9篇 |
1969年 | 6篇 |
排序方式: 共有7820条查询结果,搜索用时 15 毫秒
101.
102.
Hee Seung Hong Jiwon Baek Jae Chul Park Ho-Su Lee Dohoon Park A-Ran Yoon Soo Jung Park Sung Noh Hong Seong-Joon Koh Chang Kyun Lee Bo-In Lee Sung Wook Hwang Sang Hyoung Park Seung-Jae Myung Suk-Kyun Yang Kyuyoung Song Byong Duk Ye 《Gut and liver》2022,16(6):942
Background/AimsChronic enteropathy associated with SLCO2A1 gene (CEAS), an inherited disease characterized by nonspecific intestinal ulcers, has emerged in the Japanese population via loss-of-function mutations in the SLCO2A1 gene. We aimed to investigate the clinical and genetic characteristics of Korean patients diagnosed with CEAS.MethodsFrom July 2018 to July 2021, we performed Sanger sequencing of the SLCO2A1 gene in 46 patients with chronic intestinal ulcers. CEAS was confirmed based on known SLCO2A1 mutations. We summarized the clinical characteristics of patients with confirmed CEAS.ResultsFourteen out of 46 patients (30.4%) had genetically confirmed CEAS, and two SLCO2A1 variants were detected (splicing site variant c.940+1G>A and nonsense mutation [p.R603X] in SLCO2A1). Twelve patients (85.7%) were females and the median age at diagnosis of CEAS was 44.5 years. All patients presented with abdominal pain, and 13 patients (92.9%) presented with anemia (median hemoglobin, 9.6 g/dL). Ten patients (71.4%) had hypoalbuminemia (median, 2.7 g/dL). The most commonly involved site was the ileum (13/14, 92.9%). Manifestations of primary hypertrophic osteoarthropathy (PHO), such as digital clubbing, pachydermia, and periostosis were observed in five patients (28.6%) and two male patients and one female patient satisfied all major PHO diagnostic criteria.ConclusionsThe clinical and genetic characteristics of Korean patients with confirmed CEAS were similar to those reported in the literature. CEAS should be considered in the differential diagnosis for patients with unexplained chronic nonspecific ulcers of the small intestine. 相似文献
103.
Yun Woo Lee Jin Won Huh Sang-Bum Hong Jiwon Jung Min Jae Kim Yong Pil Chong Sung-Han Kim Heungsup Sung Kyung-Hyun Do Sang-Oh Lee Chae-Man Lim Yang Soo Kim Younsuck Koh Sang-Ho Choi 《Emerging infectious diseases》2022,28(11):2147
We investigated the proportion and characteristics of severe Corynebacterium striatum pneumonia in South Korea during 2014–2019. As part of an ongoing observational study of severe pneumonia among adult patients, we identified 27 severe C. striatum pneumonia cases. Most (70.4%) cases were hospital-acquired, and 51.9% of patients were immunocompromised. C. striatum cases among patients with severe hospital-acquired pneumonia (HAP) increased from 1.0% (2/200) during 2014–2015 to 5.4% (10/185) during 2018–2019, but methicillin-resistant Staphylococcus aureus (MRSA) infections among severe HAP cases decreased from 12.0% to 2.7% during the same timeframe. During 2018–2019, C. striatum was responsible for 13.3% of severe HAP cases from which bacterial pathogens were identified. The 90-day mortality rates were similarly high in the C. striatum and MRSA groups. C. striatum was a major cause of severe HAP and had high mortality rates. This pathogen is emerging as a possible cause for severe pneumonia, especially among immunocompromised patients. 相似文献
104.
Pyelolymphatic backflow is a rare type of pyelolymphatic fistula that occurs in cases of urinary obstruction. This phenomenon may help to decompress an acutely obstructed kidney, and therefore, alleviate renal function from deteriorating. Pyelolymphatic backflow has specific imaging characteristics best shown on CT urography. Our case study aims to improve the understanding and diagnosis of pyelolymphatic backflow by presenting a case of pyelolymphatic backflow seen on CT urography, including discussions on the pathophysiology, clinical relevance and management of this phenomenon. Our case study demonstrates the opacification of landmark lymphatic structures including the retroperitoneal para-aortic lymphatic chain, cisterna chyli and thoracic duct, which have not been demonstrated previously. 相似文献
105.
Subramanyam Vankadara Monique Danielle Dawson Jia Yi Fong Qin Yao Oh Qi An Ang Boping Liu Hong Yun Chang Judice Koh Xiaoying Koh Qian Wen Tan Joma Joy Cheng San Brian Chia 《ACS medicinal chemistry letters》2022,13(8):1345
The SARS-CoV-2 pandemic is currently causing an unprecedented global health emergency since its emergence in December 2019. In December 2021, the FDA granted emergency use authorization to nirmatrelvir, a SARS-CoV-2 main protease inhibitor, for treating infected patients. This peptidomimetic is designed with a nitrile warhead, which forms a covalent bond to the viral protease. Herein, we investigate nirmatrelvir analogs with different warheads and their inhibitory activities. In addition, antiviral activities against human alphacoronavirus 229E was also investigated along with a cell-based assay. We discovered that the hydroxymethylketone and ketobenzothiazole warheads were equipotent to the nitrile warhead, suggesting that these analogs can also be used for treating coronavirus infections. 相似文献
106.
P J Roberts-Thomson A Kennedy L Y Koh R H Harries 《Journal of reproductive immunology》1987,11(4):321-325
Thirty cord blood sera from healthy neonates and five sera from still-born infants (two with suspected infections and high IgM) were assessed for the presence of low molecular weight (LMW) IgM using two independent sensitive techniques, viz. filtration chromatography and immunoblotting. The first technique revealed this LMW moiety in 4 of 22 sera, all from healthy full-term infants, and it constituted 4-25% of the total IgM. LMW IgM was not found in any of the 30 sera using the immunoblotting technique or in 15 healthy adult sera, but was found consistently in rheumatoid sera used as positive controls. 相似文献
107.
108.
Koh DJ Ahn HS Chung HS Lee H Kim Y Lee JY Kim DG Hong M Shin M Bae H 《Journal of ethnopharmacology》2011,136(3):399-405
Ethnopharmacological relevance
The fruits of Vitex rotundifolia L. have long been used for the treatment of inflammation of the respiratory tract in East Asia.Aim
To determine if casticin, one of the constituents of Vitex rotundifolia L., has anti-allergic and anti-inflammatory effects in asthma.Materials and methods
The in vitro anti-inflammatory activity of casticin was studied in A549 human type II-like epithelial lung cells using an eotaxin inhibition assay. Additionally, its effects on eotaxin, regulated on activation normal T cell expressed and secreted (RANTES), vascular cell adhesion molecule (VCAM)-1, and inter-cellular adhesion molecule (ICAM)-1 expression were investigated by real time-polymerase chain reaction (real time-PCR). The inhibition of nuclear factor κB (NF-κB) activity in the presence of casticin was determined by analyzing confocal microscopy images of fluorescence immunocytochemical analysis while the suppression of inhibitory κB (IκB)-α phosphorylation was studied using Western blot analysis. Finally, the inhibitory effect of casticin on eosinophil migration toward prestimulated A549 cell media was measured using the human eosinophilic leukemia cell line.Results and discussion
Casticin significantly suppressed eotaxin production in cytokine activated A549 lung epithelial cells. Casticin also suppressed the mRNA expression levels of eotaxin, RANTES, VCAM-1, and ICAM-1, which subsequently contributed to the inhibition of eosinophil migration. Furthermore, casticin inhibited IκB-α phosphorylation and nuclear translocation of p65 in A549 cells.Conclusion
Casiticin inhibited the eosinophil migration and activity of chemokines and adhesion molecules involved in the inflammatory process of asthma by suppressing the NF-κB pathway. These results suggest that casticin has the potential for use in the treatment of allergic asthma. 相似文献109.
Koh Shinohara Yasuhiro Tsuchido Michio Suzuki Kojiro Yamamoto Yasutaro Okuzawa Koichi Imaoka Tsunehiro Shimizu 《Internal medicine (Tokyo, Japan)》2022,61(14):2233
Capnocytophaga species are among the typical zoonotic pathogens causing infections following direct contact with animals. Recently, a putative novel species of zoonotic Capnocytophaga, Capnocytophaga stomatis, was reported. We herein report the first case of bacteremia caused by C. stomatis. A woman in her 80s with multiple myeloma who was receiving bortezomib and dexamethasone therapy was admitted to our hospital with a 2-day history of a fever and right calf redness. She was often licked by her cat. On a blood culture, thin, Gram-negative rods were detected, which were identified as C. stomatis by whole-genome sequencing. The patient was successfully treated with ampicillin-sulbactam treatment. Our case highlights the pathogenic potential of the putative novel Capnocytophaga, C. stomatis, in immunocompromised hosts. 相似文献
110.
OBJECTIVES: Polyacrylamide hydrogel (PAAG, Aquamid) is widely used as permanent facial tissue filler during facial plastic surgery. In this study, we examined the long-term effects and safety aspects of PAAG as a vocal fold augmentation material for patients with permanent unilateral vocal cord paralysis. STUDY DESIGN: Prospective clinical trials. METHODS: PAAG injection laryngoplasty was performed in 34 consecutive patients with permanent unilateral vocal cord paralysis. Percutaneous injection was performed under local anesthesia into the vocalis muscle using disposable 25 gauge long needles. Of the 34 patients, 16 completed acoustic, perceptual, stroboscopic, and subjective evaluations prior to the injection and at 6 and 12 months after the injection. RESULTS: Acoustic and perceptual parameters (GRBAS [Overall grade of dysphonia, Roughness, Breathiness, Aesthenia, Strain], Maximal phonation time [MPT], jitter, and shimmer) were significantly improved (P < .05) after injection and remained stable over 12 months. The grades of mucosal waves and glottic closure were also significantly improved (P < .01). The voice handicap index (VHI), as well as the visual analogue scale (VAS) of hoarseness and aspiration significantly improved over 12 months. No adverse effects were observed except for a decrease in the mucosal wave of one patient, after injection into a superficial area of the vocal fold. CONCLUSION: Based on the preliminary results of this trial, PAAG appears to be a long-lasting and safe injection material that is suitable for the treatment of glottal insufficiency caused by permanent unilateral vocal cord paralysis. 相似文献