全文获取类型
收费全文 | 115556篇 |
免费 | 11741篇 |
国内免费 | 7394篇 |
专业分类
耳鼻咽喉 | 941篇 |
儿科学 | 1981篇 |
妇产科学 | 1249篇 |
基础医学 | 10735篇 |
口腔科学 | 1800篇 |
临床医学 | 16653篇 |
内科学 | 13884篇 |
皮肤病学 | 1131篇 |
神经病学 | 4710篇 |
特种医学 | 3665篇 |
外国民族医学 | 35篇 |
外科学 | 8438篇 |
综合类 | 24498篇 |
现状与发展 | 27篇 |
一般理论 | 6篇 |
预防医学 | 10601篇 |
眼科学 | 3183篇 |
药学 | 13859篇 |
178篇 | |
中国医学 | 9145篇 |
肿瘤学 | 7972篇 |
出版年
2024年 | 503篇 |
2023年 | 1848篇 |
2022年 | 4697篇 |
2021年 | 5874篇 |
2020年 | 4745篇 |
2019年 | 3713篇 |
2018年 | 3607篇 |
2017年 | 3991篇 |
2016年 | 3482篇 |
2015年 | 5392篇 |
2014年 | 6649篇 |
2013年 | 6876篇 |
2012年 | 9862篇 |
2011年 | 10459篇 |
2010年 | 7681篇 |
2009年 | 6438篇 |
2008年 | 7388篇 |
2007年 | 7123篇 |
2006年 | 6601篇 |
2005年 | 5890篇 |
2004年 | 3880篇 |
2003年 | 3408篇 |
2002年 | 2812篇 |
2001年 | 2223篇 |
2000年 | 1861篇 |
1999年 | 1573篇 |
1998年 | 942篇 |
1997年 | 905篇 |
1996年 | 725篇 |
1995年 | 638篇 |
1994年 | 576篇 |
1993年 | 371篇 |
1992年 | 335篇 |
1991年 | 318篇 |
1990年 | 288篇 |
1989年 | 223篇 |
1988年 | 213篇 |
1987年 | 158篇 |
1986年 | 137篇 |
1985年 | 98篇 |
1984年 | 47篇 |
1983年 | 29篇 |
1982年 | 19篇 |
1981年 | 31篇 |
1980年 | 14篇 |
1979年 | 12篇 |
1977年 | 6篇 |
1974年 | 5篇 |
1972年 | 6篇 |
1971年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
采用免疫组织化学S-P法检测52例手术切除乳腺癌组织c-erbB-2蛋白和HSV-1、HSV-2表达情况。结果发现癌组织中c-erbB-2阳性34例(65.4%);HSV-1阳性38例(73.1%);HSV-2阳性15例(28.8%)。癌旁组织32例,阳性分别为3例(9.4%);12例(37.5%);2例(6.3%)。乳腺癌中c-erbB-2阳性率明显高于癌旁组织。乳腺癌及癌旁的HSV-1阳性率明 相似文献
12.
928株革兰阴性杆菌耐药性监测 总被引:27,自引:4,他引:23
目的:了解青岛地区临床分离的重要革兰阴性杆菌的耐药情况以指导合理用药。方法:2001年青岛3家医院临床分离的5种革兰阴性杆菌用Kirby-Bauer法进行药敏试验。结果:5种病原菌均占3家医院革兰阴性杆菌分离率的前5位,大肠埃希菌对氟喹诺酮类药物的耐药率达60%-87%,细菌对亚胺培南均呈高度敏感,但铜绿假单胞菌耐亚胺培南株占25.8%,头孢他啶的抗菌活性是三代头孢菌素中最高的;复方酶抑制剂表现出良好的抗菌活性。结论:细菌耐药问题仍是目前临床的严重问题,地域性的耐药性监测是必要的。 相似文献
13.
【目的】探讨地塞米松的用药方式对孕妇糖代谢的影响。【方法】对 1999年 9月至 2 0 0 1年 1月在本院住院的15 0名不同用药方式使用地塞米松促胎儿肺成熟的孕妇进行研究 ,在用药前及用药后 18~ 2 4h抽取肘前静脉血查空腹血糖、血浆C肽 ,糖负荷后 2h血糖、血浆C肽。【结果】使用地塞米松后 ,空腹血糖值、糖负荷后 2h血糖值、空腹C肽及糖负荷后 2hC肽值较用药前高 ;用药方式对母体空腹血糖值和空腹C肽值的影响差异无统计学意义 (P >0 0 5 ) ,对母体糖负荷后 2h血糖值和糖负荷后 2hC肽值的影响差异有统计学意义 (P <0 0 5 ) ;不同糖代谢状态的受试者使用地塞米松后 ,空腹C肽值、糖负荷后 2hC肽值的改变差异有统计学意义 (P <0 0 5 )。【结论】孕妇使用地塞米松促胎儿肺成熟对母体的糖代谢均有一定程度的影响 ,用药过程中和用药后需严密监测母体血糖和胎儿宫内状况 相似文献
14.
本文从12379枚离体牙上观测了釉珠的发生率、发生部位、形态、直径大小。结果釉珠的发生率为2.49%,以上颌第三磨牙发生率最高,下颌第一磨牙次之。最常发生的部位是在冠颈部的根分叉处,上颌磨牙的釉珠多呈园形,下颌磨牙釉珠多呈梭形。釉珠最大直径为3.2mm,最小为0.5mm,平均为1.56mm。结合文献认为釉珠是一种牙齿形态发育异常,它对牙周病的发生、发展、治疗与预后有重要影响,口腔科医师对这种牙齿形态变异应予以重视。 相似文献
15.
In this article, the authors review the cellular mechanisms of epileptogenicity in malformations caused by abnormalities of cortical development as related to neuronal excitation, reduced inhibition, disorganized synaptic connections, and glial function (or dysfunction). 相似文献
16.
报告12例疸性腔皮病患者的性别与年龄构成、并发症、实验室检查、治疗经过和结果,对该病的病因、治疗和预后进行了讨论。 相似文献
17.
Lin Bo Wang Jian Guo Shen Li Feng Dong Chao Yang Xu Wen Jun Chen Shu Duo Xie Xiang Yang Song Ning Dai Xiao Ming Yuan 《Journal of gastrointestinal surgery》2008,12(8):1359-1363
We previously reported that lymphatic mapping using isosulfan blue can be used to identify sentinel nodes (SNs). This study
was undertaken to evaluate the feasibility of using the SN technique in treating early gastric cancer and to explore its usefulness
for minimal invasive surgery. Twenty-three patients with early gastric cancer who underwent SN biopsy were retrospectively
evaluated. Based on SN evaluation, individualized surgery was performed in five patients with T1N0M0 gastric cancer. When
pathological examination of frozen sections revealed metastasis in SNs, we performed a standard D2 gastrectomy. Laparoscopic
local resection was applied when the SN biopsy was negative. Our results showed that the success rate with SN biopsy in early
gastric cancer was 100%, as were the accuracy, sensitivity, and specificity. All five patients with early gastric cancer had
SNs negative for metastases both by frozen section and by postoperative pathology. Thus, all these patients underwent laparoscopic
local resection without extended lymphadenectomy. We conclude that SN biopsy is a useful tool to individualize the operative
procedure, and laparoscopic local resection can be safely performed using SN guidance in selected patients with early gastric
cancer. 相似文献
18.
M. Laurin Council Jennifer M. Gardner Cynthia Helms Ying Liu Lynn A. Cornelius Anne M. Bowcock 《Experimental dermatology》2009,18(5):485-487
Abstract: The risks of developing malignant melanoma (MM) include ultraviolet irradiation and genetic factors. To examine the contribution of rare and common variation within known MM genes in sporadic US MM patients, coding regions of known MM susceptibility genes [cyclin-dependent kinase inhibitor 2A ( CDKN2A ), cyclin-dependent kinase 4, melanocortin 1 receptor ( MC1R ) and tyrosinase ( TYR )] were resequenced in 109–135 MM cases. The significance of variants was examined by comparing their frequencies in 390 cancer-free controls. Potential deleterious mutations in CDKN2A were found in two patients and two others had variants of unknown significance. Cases were more likely than controls to harbour the MC1R 'R' variants known or predicted to alter its function ( P = 0.002), particularly the R160W variant ( P = 0.0035). The associated TYR R402Q variant (rs1126809*A) was found in 29% of cases, similar to what has been described previously. One MM patient with a family history of MM, who had developed other skin cancers, was homozygous for a novel TYR variant (P406L) of unknown significance. Hence, rare variants in TYR may be important risk factors for skin cancer. 相似文献
19.
Erik D Skarsgard Ying C MacNab Zhenguo Qiu Ruth Little Shoo K Lee 《Journal of perinatology》2005,25(5):315-319
OBJECTIVE: Outcomes analysis in congenital diaphragmatic hernia (CDH) requires a validated risk-adjustment tool. The purpose of this study was to use the Canadian Neonatal Network (CNN) database to validate the Score for Neonatal Acute Physiology, Version II (SNAP-II) for prediction of mortality among CDH infants admitted to a neonatal intensive care unit (NICU), and to compare this to the predictive equation recently developed by the Congenital Diaphragmatic Hernia Study Group (CDHSG). STUDY DESIGN: Infants with CDH in the CNN database were identified. Bivariate and multivariable logistic regression models were used to identify risk factors predictive of mortality. Model predictive performance and calibration were assessed using the area under the receiver operator characteristic curve and the technique of Hosmer-Lemeshow, respectively, and compared with the CDHSG predictive equation. RESULTS: There were 88 patients with CDH among 19,507 admissions to CNN hospitals. The mortality rate among CDH patients surviving to NICU admission was 17%, and 12.5% received extracorporeal membrane oxygenation therapy. Gestational age and admission SNAP-II score predicted mortality. Model predictive performance and calibration were optimized with these variables combined. The CDHSG equation was equally predictive of mortality, but was only marginally calibrated. CONCLUSIONS: SNAP-II is highly predictive of mortality among patients with CDH, and can be used to risk-adjust these patients. 相似文献
20.
嵌体与全冠治疗牙间食物嵌塞的临床应用比较 总被引:3,自引:0,他引:3
目的:比较嵌体与全冠治疗牙间食物嵌塞的临床操作及修复效果.方法:对纳入标准的78例患者随机分组,分别用嵌体和全冠进行修复并进行随访观察,并对两种方法的临床应用效果进行比较.结果:在对牙龈及牙周保护方面,嵌体与全冠有显著性差异;在边缘密合、重塑邻接关系及牙齿敏感方面,二者无显著性差异.结论:嵌体较全冠修复牙间食物嵌塞临床操作简便省时,更有利于保护牙髓及牙周组织健康,美观经济. 相似文献