全文获取类型
收费全文 | 6477篇 |
免费 | 541篇 |
国内免费 | 118篇 |
专业分类
耳鼻咽喉 | 47篇 |
儿科学 | 133篇 |
妇产科学 | 297篇 |
基础医学 | 749篇 |
口腔科学 | 142篇 |
临床医学 | 761篇 |
内科学 | 1429篇 |
皮肤病学 | 88篇 |
神经病学 | 619篇 |
特种医学 | 421篇 |
外科学 | 700篇 |
综合类 | 155篇 |
一般理论 | 2篇 |
预防医学 | 367篇 |
眼科学 | 172篇 |
药学 | 396篇 |
1篇 | |
中国医学 | 63篇 |
肿瘤学 | 594篇 |
出版年
2023年 | 37篇 |
2022年 | 70篇 |
2021年 | 143篇 |
2020年 | 83篇 |
2019年 | 182篇 |
2018年 | 205篇 |
2017年 | 168篇 |
2016年 | 189篇 |
2015年 | 241篇 |
2014年 | 277篇 |
2013年 | 339篇 |
2012年 | 439篇 |
2011年 | 470篇 |
2010年 | 299篇 |
2009年 | 290篇 |
2008年 | 329篇 |
2007年 | 353篇 |
2006年 | 362篇 |
2005年 | 275篇 |
2004年 | 264篇 |
2003年 | 238篇 |
2002年 | 204篇 |
2001年 | 159篇 |
2000年 | 150篇 |
1999年 | 125篇 |
1998年 | 74篇 |
1997年 | 80篇 |
1996年 | 63篇 |
1995年 | 43篇 |
1994年 | 44篇 |
1993年 | 41篇 |
1992年 | 77篇 |
1991年 | 80篇 |
1990年 | 65篇 |
1989年 | 73篇 |
1988年 | 52篇 |
1987年 | 44篇 |
1986年 | 58篇 |
1985年 | 47篇 |
1984年 | 34篇 |
1983年 | 38篇 |
1982年 | 37篇 |
1981年 | 34篇 |
1980年 | 19篇 |
1979年 | 23篇 |
1978年 | 25篇 |
1977年 | 21篇 |
1975年 | 22篇 |
1974年 | 30篇 |
1973年 | 21篇 |
排序方式: 共有7136条查询结果,搜索用时 15 毫秒
71.
Validating and implementing the use of an infusion pump for the administration of thawed hematopoietic progenitor cells—a single‐institution experience 下载免费PDF全文
72.
Latham HL Fink Noelle C Anastasio Robert G Fox Kenner C Rice F Gerard Moeller Kathryn A Cunningham 《Neuropsychopharmacology》2015,40(8):1957-1968
Impulsivity is an important feature of multiple neuropsychiatric disorders, and individual variation in the degree of inherent impulsivity could play a role in the generation or exacerbation of problematic behaviors. Serotonin (5-HT) actions at the 5-HT2AR receptor (5-HT2AR) promote and 5-HT2AR antagonists suppress impulsive action (the inability to withhold premature responses; motor impulsivity) upon systemic administration or microinfusion directly into the medial prefrontal cortex (mPFC), a node in the corticostriatal circuit that is thought to play a role in the regulation of impulsive action. We hypothesized that the functional capacity of the 5-HT2AR, which is governed by its expression, localization, and protein/protein interactions (eg, postsynaptic density 95 (PSD95)), may drive the predisposition to inherent impulsive action. Stable high-impulsive (HI) and low-impulsive (LI) phenotypes were identified from an outbred rodent population with the 1-choice serial reaction time (1-CSRT) task. HI rats exhibited a greater head-twitch response following administration of the preferential 5-HT2AR agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) and were more sensitive to the effects of the selective 5-HT2AR antagonist M100907 to suppress impulsive action relative to LI rats. A positive correlation was observed between levels of premature responses and 5-HT2AR binding density in frontal cortex ([3H]-ketanserin radioligand binding). Elevated mPFC 5-HT2AR protein expression concomitant with augmented association of the 5-HT2AR with PSD95 differentiated HI from LI rats. The observed differential sensitivity of HI and LI rats to 5-HT2AR ligands and associated distinct 5-HT2AR protein profiles provide evidence that spontaneously occurring individual differences in impulsive action reflect variation in the cortical 5-HT2AR system. 相似文献
73.
Chang Chi-Ching Yen Yu-Chun Lee Cheng-Yi Lin Chiou-Feng Huang Chao-Ching Tsai Ching Wen Chuang Ting-Wu Bai Chyi-Huey 《Clinical rheumatology》2021,40(2):537-546
Clinical Rheumatology - The data concerning the association between dengue viruses (DV) infection and autoimmune diseases (ADs) remain unclear and are scarce. This nationwide population-based... 相似文献
74.
Pei-Yi Yu Yusen Eason Lin Wei-Ru Lin Hsiu-Yun Shih Yin-Ching Chuang Ren-Jy Ben Wen-Kuei Huang Yao-Shen Chen Yung-Ching Liu Feng-Yee Chang Muh-Yong Yen Ching-Chuan Liu Wen-Chien Ko Hsi-Hsun Lin Zhi-Yuan Shi 《International journal of infectious diseases》2008,12(4):416-420
BACKGROUND: The major sources of Legionnaires' disease (LD) are the potable water systems of large buildings including hospitals, nursing homes, and hotels. Culturing the hospital water system for Legionella allows a preventive approach for hospital-acquired LD. However, hospital-acquired LD is rarely reported in Taiwan, and environmental cultures of Legionella in hospital water systems in Taiwan have never been systematically performed. OBJECTIVE: The objective of this study was to determine if Legionella is present in hospital water systems in Taiwan. Water quality analysis was also performed to determine if geographic differences in water quality result in different Legionella positivity rates. METHOD: The water systems of 16 hospitals throughout Taiwan were tested for Legionella by culture. Standardized culture procedures were followed. RESULTS: Legionella pneumophila was isolated from 63% (10/16) of the hospital water systems; 19% (3/16) of the hospitals had an L. pneumophila positive rate greater than 30%. L. pneumophila serogroups 1 and 6 (strains that are most responsible for Legionella infections) were isolated from 80% (8/10) and 60% (6/10), respectively, of the hospitals that yielded L. pneumophila in their water distribution systems. CONCLUSION: As was shown in epidemiological studies in the USA and Spain, hospital-acquired legionellosis may be prevalent but underdiagnosed in Taiwan. 相似文献
75.
Lin TH Huang CH Voon WC Yen HW Lai HM Liang HY Lu YH Lee KT Lee CS Lai WT Sheu SH 《The Kaohsiung journal of medical sciences》2000,16(12):600-606
Several studies have shown cardiovascular benefit in treating hypercholesterolemia with HMG-CoA reductase inhibitor. However, in addition to the lowering of cholesterol, the beneficial effects of this inhibitor reflect other pharmacological activities. Whether these beneficial effects are partly mediated by changes in fibrinolytic factors remains to be proven, since clinical studies on the effects of HMG-CoA reductase inhibitors on fibrinolytic factors have not yielded consistent results. The purpose of this study was to evaluate the effects of fluvastatin on fibrinolytic factors in hypercholesterolemic patients. After 6 weeks on a low-fat, low-cholesterol diet, 23 outpatients known to have primary hypercholesterolemia with low density lipoprotein cholesterol (LDL-C) > or = 130 mg/dl with at least 2 risk factors or fasting LDL-C > or = 160 mg/dl were selected for the study. Venous blood samples were collected at baseline and at 8 weeks after fluvastatin therapy (40 mg/day) to measure of tissue plasminogen activator (t-PA), plasminogen activators inhibitor-1 (PAI-1), fibrinogen, D-dimer and lipid profile. After 8 weeks of therapy, fluvastatin reduced serum cholesterol by 11% (261.9 mg/dl vs 233.2 mg/dl, P < 0.01) and LDL-C by 22% (191.9 mg/dl vs 149.3 mg/dl, P < 0.01). D-dimer was significantly decreased (0.38 ng/L vs 0.28 ng/L, P = 0.02) and tPA, PAI-1 and fibrinogen tended to decrease after therapy. Fluvastatin therapy improved fibrinolytic profile; the result of this study may in part explain the benefit of HMG-CoA reductase inhibitor on cardiovascular system other than lipid lowering. 相似文献
76.
77.
R K Firmin R Lima R H Anderson S Yen Ho C Lincoln 《The Thoracic and cardiovascular surgeon》1983,31(6):365-368
Two cases of double outlet right ventricle with subpulmonary ventricular septal defect treated by arterial switch operations are reported. The anatomical problems of coronary artery transfer, occult outflow tract obstruction and position of the pulmonary bifurcation are discussed. Cases of double outlet right ventricle and subpulmonary ventricular septal defect with anterior-to-posterior relation of the great arteries are suited to the repair techniques pioneered by Jatene for complete transposition and ventricular septal defect. Cases in which the great arteries are side-by-side pose more difficult problems, partly because of the more complex and varied anatomy of the coronary arteries, and because of the spatial relation of the roots of the great arteries. Although it may be possible to overcome these technical problems, we have reservations about the reproducibility of such a procedure. We believe, however, that cases of this type are best treated without recourse to "inflow" correction. The options are either the arterial switch procedure or a modified Rastelli operation. 相似文献
78.
Compared with the coronary arterial system, less attention has been paid to the coronary venous system. In the current era, there are therapeutic options for arrhythmias and for heart failure that use the coronary venous system to access target areas. We review the arrangement of the main cardiac veins to provide a morphologic background to interventionists. In general, the venous system is a useful conduit for delivery of percutaneous transcatheter treatment. But, variability in terms of valves, diameter, angulation, extent of muscular sleeves, proximity to other cardiac structures, and cross-over spatial relationship with branches of coronary arteries have implications for practitioners seeking to make use of the system. 相似文献
79.
80.
To further clarify the association of HLA DR alleles with type 1 diabetes mellitus and the influence of age-onset and gender on type 1 diabetes, we investigated HLA-DR in 76 child onset Chinese (36 males) type 1 diabetes patients and 154 normal controls by using PCR-SSP (sequence specific primer). The mean age of onset of diabetes patients was 8.43 +/- 3.96 year-old. Our results revealed that the frequencies of DR3, DR4 and DR9 in diabetes patients were significantly higher than those in control group (all P < 0.01). The susceptible alleles were DR3, DR4, DR9, with relative risks of 8.25, 2.57 and 2.67, respectively. The protective alleles to type 1 diabetes were DR 2, DR8, DR11 and DR12 with relative risk of 0.24, 0.15, 0.16 and 0.39, respectively. There were no significant differences between the frequencies of HLA DR 3, DR4, DR9, DR3/4, DR3/9 and DR4/9 in male and female diabetic children. We divided the diabetes patients into three groups according to their age of onset (1-5 years old, 6-10 years old and 11-17 years old). There was a trend that the frequencies of DR9 decreased with the increase of age at onset, but there was no significant difference of DR3, DR4, DR9, DR3/4, DR3/9 and DR4/9 frequencies between diabetes children with age onset 0-10 years and 11-17 years. As to the influence of gender on the HLA genotypes, the frequency of DR3/4 decreased with the increase of age at onset for male patients and the frequency of DR3/4 increased with the increase of age at onset for female patients. 相似文献