全文获取类型
收费全文 | 5888篇 |
免费 | 340篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 47篇 |
儿科学 | 137篇 |
妇产科学 | 44篇 |
基础医学 | 801篇 |
口腔科学 | 171篇 |
临床医学 | 350篇 |
内科学 | 1621篇 |
皮肤病学 | 100篇 |
神经病学 | 432篇 |
特种医学 | 162篇 |
外科学 | 898篇 |
综合类 | 38篇 |
预防医学 | 131篇 |
眼科学 | 256篇 |
药学 | 472篇 |
中国医学 | 13篇 |
肿瘤学 | 578篇 |
出版年
2023年 | 41篇 |
2022年 | 78篇 |
2021年 | 102篇 |
2020年 | 73篇 |
2019年 | 87篇 |
2018年 | 114篇 |
2017年 | 113篇 |
2016年 | 110篇 |
2015年 | 115篇 |
2014年 | 133篇 |
2013年 | 174篇 |
2012年 | 291篇 |
2011年 | 324篇 |
2010年 | 192篇 |
2009年 | 178篇 |
2008年 | 291篇 |
2007年 | 335篇 |
2006年 | 304篇 |
2005年 | 263篇 |
2004年 | 271篇 |
2003年 | 271篇 |
2002年 | 260篇 |
2001年 | 249篇 |
2000年 | 226篇 |
1999年 | 191篇 |
1998年 | 81篇 |
1997年 | 52篇 |
1996年 | 68篇 |
1995年 | 40篇 |
1994年 | 37篇 |
1993年 | 30篇 |
1992年 | 116篇 |
1991年 | 100篇 |
1990年 | 95篇 |
1989年 | 88篇 |
1988年 | 95篇 |
1987年 | 84篇 |
1986年 | 94篇 |
1985年 | 73篇 |
1984年 | 58篇 |
1983年 | 39篇 |
1982年 | 17篇 |
1980年 | 23篇 |
1979年 | 32篇 |
1975年 | 27篇 |
1974年 | 24篇 |
1972年 | 21篇 |
1968年 | 16篇 |
1967年 | 19篇 |
1966年 | 17篇 |
排序方式: 共有6251条查询结果,搜索用时 15 毫秒
91.
Y. Suzuki M. Urashima Y. Ishibashi M. Abo N. Omura K. Nakada N. Kawasaki K. Eto N. Hanyu K. Yanaga 《European journal of surgical oncology》2005,31(10):1166-1174
AIM: To prove the feasibility of hand-assisted laparoscopic and thoracoscopic surgery (HALTS) for radical esophagectomy with three-field lymphadenectomy to thoracic esophageal cancer. METHODS: Esophagectomy with three-field lymphadenectomy was performed using HALTS in 19 patients with thoracic esophageal cancer without distant metastasis. Five patients had chemo-radiotherapy prior to surgery. RESULTS: All operations were completed successfully without the need for open surgery. Mean surgical time was 476+/-58 min, and mean blood loss during surgery was 343+/-184 mL. All patients started tube feeding and were moved from the intensive care unit to the general surgery ward the day after surgery. Discharge occurred a median of 10 days after surgery. Fifteen patients could return to full time jobs from 8 to 62 days after surgery (median 22 days) and from 1 to 35 days after discharge (median 9 days). Other three could return to daily activities at home soon as well. No major complications occurred, except one anastomotic leak. In terms of lung function, %FEV(1) was not changed whereas %VC was reduced significantly 1 month after surgery. All but two recurrences have been healthy without a relapse for a mean of 289 days. CONCLUSIONS: These results suggest that HALTS may be a useful surgical technique to reduce the invasiveness of conventional radical esophagectomy with three-field lymphadenectomy for thoracic esophageal cancer. 相似文献
92.
Kodaka M Miyao H Kawasaki J Kawazoe T Fujioka M Ogawa Y 《Masui. The Japanese journal of anesthesiology》2000,49(9):1011-1014
Two extremely-low-birth-weight infants, weighing each 684 and 975 g at birth, underwent emergency surgery because of ileus. Our previous experience with an extremely low birth weight infant, whose hemodynamic control during the surgery had been difficult without administering extra preoperative fluid and transfusion, made us administer enough fluid and transfusion during operation although their urine output was more than 2 ml.kg-1.hr-1. We gave intravenous volume to the present 2 cases before the operations despite the level of preoperative urine output and made their hemodynamic situation more stable during surgeries. We conclude it is very important to administer some amounts of intravenous volume (approximately 8-12 ml.kg-1.hr-1) in extremely low birth weight infants for emergency surgery with ileus regardless of their preoperative urine output. 相似文献
93.
Yoshitaka Maeda Sayaka Yoshida Toshiyuki Hirai Tomoki Kawasaki Tamaki Kuyama 《Journal of Rural Medicine》2013,8(1):171-175
Objective: The usefulness of estimated glomerular filtration rate may not be
restricted to pre-dialysis patients, since we reported that estimated glomerular
filtration rate was well correlated with measured total creatinine clearance in peritoneal
dialysis patients. To clarify the clinical usefulness of estimated glomerular filtration
rate as a parameter for peritoneal dialysis adequacy, we retrospectively surveyed
estimated glomerular filtration rate and total creatinine clearance in peritoneal dialysis
patients treated at JA Toride Medical Center.Patients and Methods: A total of 114 data sets of estimated glomerular
filtration rate and total creatinine clearance from 21 PD patients treated at JA Toride
Medical Center were collected from November 2010 to October 2011. The patients consisted
of 15 men and six women with an average age of 66.6 ± 12.6 years (46–95 years old). The
average number of samples was 5.4 ± 1.5 (2 to 7) per patient.Results: The collected data showed less correlation of estimated glomerular
filtration rate and total creatinine clearance (r. = 0.435) than that of a previous
cross-sectional study (r. = 0.836). As reported in pre-dialysis patients, the differences
between estimated glomerular filtration rate and total creatinine clearance were
correlated with total creatinine excretion in urine and PD effluent (r. = 0.821). The
differences were also correlated with normalized protein catabolic rate, which was one of
the main determinant factors for total creatinine excretion (r. = 0.636). A similar
tendency was apparently observed in one patient with poor compliance to diet therapy and
fluctuating dietary intake. From the analysis of these data, serum creatinine seemed to
fluctuate less possibly due to compensatory capacity of the residual renal function in
small solute clearance.Conclusions: Consequently, estimated glomerular filtration rate was turned
out to be a more stable parameter than total creatinine clearance, which might be a
desirable feature in long-term follow-up of peritoneal dialysis patients. 相似文献
94.
95.
96.
97.
98.
99.
100.
Miyaaki H Ichikawa T Yatsuhashi H Taura N Miuma S Usui T Mori S Kamihira S Tanaka Y Mizokami M Nakao K 《Hepatology research》2011,41(12):1216-1222
Aim: The aim of this study was to investigate the relationship among the expression of suppressor of cytokine signaling 3 (SOCS 3) in the liver, the SNPs in the IL28B locus, and the outcome of interferon therapy. Methods: Prior to interferon treatment, we immunostained 67 liver specimens from chronic hepatitis C (CHC) patients who were receiving peginterferon alpha‐2b/ribavirin therapy for suppressor of cytokine signaling 3 (SOCS3), and compared the expression of SOCS3, IL28 polymorphisms and other clinical factors between the patients and compared their eventual outcomes. Results: Significant differences between the low SOCS3 group and high SOCS3 group were found in age, as well as in the platelet, transaminase, gamma‐glutamyl transpeptidase levels. The incidence of high SOCS3 was not significantly different between subjects with the TT genotype and the TG genotype (TT : TG = 71%:29%, P = 0.250). In a multivariate analysis, age (≥65 years old) (odds ratio 0.221 [0.120–0.966], P = 0.045), IL28B gene (genotype TT) (odds ratio 5.422 [1.254–23.617], P = 0.024) and SOCS3 (high) (odds ratio 0.308 [0.104–0.948], P = 0.040) were significant predictors of the interferon response. In patients with the TT genotype, those with low SOCS3 immunostaining showed a high sustained virological response (69%), while the sustained virological rate was low (27%) in the patients with high SOCS3 immunostaining. Conclusions: Using a combination of the SOCS3 immunostained area in the liver and the expression of IL28B single nucleotide polymorphisms might be a useful predictor of hepatitis C virus clearance by interferon therapy. 相似文献