全文获取类型
收费全文 | 18807篇 |
免费 | 923篇 |
国内免费 | 128篇 |
专业分类
耳鼻咽喉 | 200篇 |
儿科学 | 309篇 |
妇产科学 | 167篇 |
基础医学 | 2144篇 |
口腔科学 | 387篇 |
临床医学 | 1168篇 |
内科学 | 4979篇 |
皮肤病学 | 319篇 |
神经病学 | 1126篇 |
特种医学 | 762篇 |
外科学 | 3686篇 |
综合类 | 104篇 |
预防医学 | 541篇 |
眼科学 | 324篇 |
药学 | 1100篇 |
中国医学 | 76篇 |
肿瘤学 | 2466篇 |
出版年
2023年 | 121篇 |
2022年 | 236篇 |
2021年 | 448篇 |
2020年 | 252篇 |
2019年 | 339篇 |
2018年 | 431篇 |
2017年 | 338篇 |
2016年 | 440篇 |
2015年 | 457篇 |
2014年 | 552篇 |
2013年 | 627篇 |
2012年 | 1003篇 |
2011年 | 1182篇 |
2010年 | 671篇 |
2009年 | 516篇 |
2008年 | 992篇 |
2007年 | 1112篇 |
2006年 | 1043篇 |
2005年 | 1067篇 |
2004年 | 1065篇 |
2003年 | 1030篇 |
2002年 | 1006篇 |
2001年 | 452篇 |
2000年 | 412篇 |
1999年 | 407篇 |
1998年 | 238篇 |
1997年 | 201篇 |
1996年 | 183篇 |
1995年 | 151篇 |
1994年 | 116篇 |
1993年 | 132篇 |
1992年 | 245篇 |
1991年 | 209篇 |
1990年 | 210篇 |
1989年 | 195篇 |
1988年 | 183篇 |
1987年 | 166篇 |
1986年 | 156篇 |
1985年 | 171篇 |
1984年 | 113篇 |
1983年 | 117篇 |
1982年 | 60篇 |
1979年 | 80篇 |
1978年 | 67篇 |
1977年 | 52篇 |
1975年 | 47篇 |
1974年 | 50篇 |
1973年 | 53篇 |
1971年 | 49篇 |
1969年 | 46篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
71.
Keiko Imamura Kenji Wada Kenichi Yasui Kazuhiro Nakaso Yasuhiro Watanabe Hisanori Kowa Kenji Nakashima 《Clinical neurology》2004,44(7):446-449
A 61-year-old man had been treated for malignant fibrous histiocytoma with the pulmonary and the lymph node metastasis in the department of orthopedics in our hospital. He was admitted to our department because of an acute onset of conscious disturbance and non-fluent aphasia. Diffusion-weighted imaging (DWI) showed high signal intensity areas in the bilateral cerebella, thalami and posterior lobes. T2WI did not show any mass effects. Enhanced CT did not reveal any enhanced lesion. He was diagnosed as having cerebral embolism, and his conscious disturbance was improved after medication. Eight weeks later, he presented dysphagia, dysarthria, and ataxia in his extremities. DWI showed multiple lesions of low signal intensity located at the identical place where had showed high signal intensity in the initial DWI. T2WI showed high signal intensity area with mass effect. It was indicated that cerebral metastasis might grow after tumorgenic embolism. This is a rare case that tumor emboluses were developed to the metastatic brain tumors. 相似文献
72.
Primary leiomyosarcoma of the thyroid gland 总被引:1,自引:0,他引:1
Osamu Ozaki Kiminori Sugino Takashi Mimura Kunihiko Ito Seiichi Tamai Yasuhiro Hosoda 《Surgery today》1997,27(2):177-180
Primary leiomyosarcoma of the thyroid gland is extremely rare, and to the best of our knowledge only five well-documented
cases have been reported in the world literature. We herein report a 58-year-old female patient with primary leiomyosarcoma
of the thyroid who was successfully treated by total thyroidectomy with a modified neck dissection. Immunohistochemically,
the tumor cells showed positive reactivity to α-smooth muscle actin and vimentin. Radical surgery was thus considered to be
essential in the treatment of this rare but rather aggressive malignancy. 相似文献
73.
Clinical effects of percutaneous cardiopulmonary support in severe heart failure: early results and analysis of complications. 总被引:2,自引:0,他引:2
Shigeru Sakamoto Junichi Matsubara Toshiaki Matsubara Yasuhiro Nagayoshi Shinji Shono Hisateru Nishizawa Masaaki Kanno Katsunori Takeuchi Toshimichi Nonaka Jun Kyosawa 《Annals of thoracic and cardiovascular surgery》2003,9(2):105-110
Between January 1993 and December 2001, we employed percutaneous cardiopulmonary support (PCPS) in 35 patients. PCPS was used for postcardiotomy in 25 of these patients who could not be weaned from cardiopulmonary bypass (CPB) because of severe cardiogenic shock. In the other 10 patients, PCPS was used for a non-surgical disease. Twenty-nine patients (82.9%) were weaned from PCPS, and 28 (80.0%) survived. The other 7 patients (20.0%) died due to postoperative complications. The causes of death were multiple organ failure (MOF) due to wound bleeding, low cardiac output syndrome (LOS), myonephropathic metabolic syndrome (MNMS) with severe lower limbs ischemia, cerebrovascular accident (CVA), and sepsis. The first cause for the complications was postoperative sustained severe heart failure. To improve the survival rate, it was necessary to prevent bleeding and begin PCPS at an earlier stage. 相似文献
74.
Toshimichi Hasegawa Yuko Tazuke Yasuhiro Iwasaki Osamu Monta Junichi Sumimura Hiroshi Koyama Toru Dezawa 《Surgery today》1997,27(12):1191-1194
We report herein the case of a premature infant with esophageal atresia (EA) and a tracheoesophageal fistula (TEF) associated
with cardiac anomalies who was successfully treated by an early ligation of the TEF following gastrostomy, and delayed repair
of the esophagus. A 1212-g male was born prematurely at 31 gestational weeks, at which time he was diagnosed as having EA
with TEF and patent ductus arteriosus (PDA), ventricular septal defect (VSD), and atrial septal defect (ASD). A gastrostomy
was initially performed but following extubation he gradually became tachypneic. A chest roentogenogram revealed atelectasis
and ground-glass appearance, and reintubation was required. Ligation of the TEF was performed 53h after his birth. Following
the improvement of his respiratory condition through ventilatory support and the intratracheal administration of pulmonary
surfactant, he underwent repair of the esophagus on the 6th day of life. Postoperatively, he suffered from heart failure,
but was treated with peritoneal dialysis and pharmacological closure of the PDA. Weaning the infant from the ventilator proved
difficult, but it was finally achieved when he had reached a weight of 2268g at 3 months of age by enteral feeding. Our experience
of this case demonstrates that early ligation of TEF should be performed for a premature infant with EA and TEF before respiratory
distress syndrome (RDS) has developed. If a gastrostomy is required to prevent gastric distention, it should be followed by
simultaneous or immediate ligation of the TEF. 相似文献
75.
Masaki Ando Tsuguo Igari Seiichi Ando Hirono Satokawa Hitoshi Yokoyama 《Annals of thoracic and cardiovascular surgery》2004,10(1):47-50
A 31-year-old adult with an aortico-left ventricular tunnel (ALVT) arising from the right aortic sinus is reported. Preoperative transesophageal echocardiography demonstrated a ruptured sinus of Valsalva with severe aortic valve regurgitation which originated from the right coronary sinus entering the outlet portion of the left ventricular outflow tract. Operation revealed the aortic entrance of the tunnel was above the right coronary sinus. Direct closure of the orifice of the tunnel using three stitches of 4-0 polypropylene with felt and aortic valve replacement (AVR) was performed. At 10-month follow-up the patient is asymptomatic and receiving no oral medications except anticoagulants. We believe this to be the oldest case of ALVT managed with AVR. 相似文献
76.
T Yokoyama H Kaneko S Kawamura M Tanaka T Chiba M Hiura S Moriwaki 《Gan no rinsho》1987,33(8):975-980
A case of a cervical cancer in a 40-year-old woman with a plasma carcinoembryonic antigen (CEA) level of 29.4 ng/ml was investigated using light and electron microscopy. In addition, the plasma CEA levels before treatment were determined in 168 patients with cervical cancer and in 33 patients with endometrial cancer. CEA was found to be elevated in the plasma of 19% of those with cervical cancer and in 6% of those with endometrial cancer. Effective serial plasma CEA determinations following therapy, in patients whose plasma or tumors initially contain elevated amounts of antigen, might be useful as an adjunctive method in the earlier detection of a recurrent cancer. 相似文献
77.
78.
S. Nakasu Y. Nakasu M. Nakajima M. Yokoyama M. Matsuda J. Handa 《Acta neurochirurgica》1996,138(6):763-770
Summary Cell kinetic study plays an important role in treatment planning of brain tumour patients. MIB-1 antibody has recently become available, which detects Ki-67 antigen even in the formalin-fixed paraffin-embedded specimens. We performed MIB-1 immunostaining in 50 meningiomas and 50 neurinomas, and estimated the cell cycle time (tc) and potential doubling time (Tpot) from MIB-1 staining index (MIB-1 SI) and mitotic index (MI). MIB-1 SI logarithmically correlated with MI in both meningiomas and neurinomas. The tc and the Tpot were expressed as a function of the mitosis time (tm), while the tm is known to be around one hour and not exceeding two hours. When the tm was assumed to be one hour, the average tcs of meningiomas and neurinomas were 6.53±3.56 days and 7.67±3.27 days, respectively. The Tpots were447 × (MIB-1 SI)–1.29 × tm in meningiomas, and490 × (MIB-1 SI)
–0.98
× tm in neurinomas.The tumour doubling times (Tds) were calculated from serial imaging studies in 22 neurinomas and 15 meningiomas. The Tds were formulated as794 × (MIB-1 SI)
–0.83 in meningiomas and1380 × (MIB-1 SI)
–0.97 in neurinomas. Most of the Tds correlated well with the Tpots in meningiomas and neurinomas, and exceeded values of the Tpot when the tm is assumed to be one hour, although a few tumours showed unexpectedly longer Tds. The Tpot and the tc estimated from MIB-1 SI and MI are clinically useful parameters for predicting the growth potential of meningiomas and neurinomas where no other simple methods are available. 相似文献
79.
Natural interferon enhances expression of placental alkaline phosphatase in human seminoma xenograft
T. Imao K. Koshida H. Konaka T. Uchibayashi K. Yokoyama K. Hirano M. Namiki 《Urological research》1998,26(6):377-382
The purpose of this study was to investigate the effect of natural interferon (IFN) on the expression of placental alkaline
phosphatase (PLAP) in a human seminoma xenograft in severe combined immunodeficient mice. Mice were injected intramuscularly
with 3 × 105 U/mouse of IFN, twice a day, for five consecutive days. A significant increase in PLAP level of the xenografts followed IFN
treatment. A radiolabeled anti-PLAP monoclonal antibody (MAb) was intravenously injected on the first day of IFN administration
in order to determine if IFN has the potential to enhance the efficacy of an anti-PLAP MAb in the detection of seminoma. Enhanced
retention of the anti-PLAP MAb was observed at 7 and 11 days after MAb administration. Thus, IFN treatment appears to have
some effect on the efficacy of the anti-PLAP MAb in the detection of seminoma xenografts.
Received: 26 September 1997 / Accepted: 23 April 1998 相似文献
80.
Kazunari Okada Yang Il Kim Kimihiro Nakashima Izuru Tada Takanori Yoshida Michio Kobayashi Shigeo Yokoyama 《Surgery today》1993,23(7):626-631
A case of small fibrolamellar hepatocellular carcinoma (HCC) coexistent with a HCC of common type is herein reported. A 56-year-old man was diagnosed as having multi-nodular type HCC with liver cirrhosis. The serum alpha-fetoprotein (AFP) level was slightly increased. The patient underwent a partial caudate lobectomy and lateral segmentectomy. Histologically, both resected tumors were small HCCs measuring less than 2 cm in diameter. One was a fibrolamellar type located in the caudate lobe, while the other was the common type in the lateral segment of the liver. Positive immunohistochemical staining for AFP was observed in the tumor cells of the HCC of common type but was not observed in the fibrolamellar HCC. We also reviewed previously reported cases of fibrolamellar HCC in Japan, and discussed the clinicopathologic implications of this disease. 相似文献