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71.
Motonobu Kameyama Kiichi Ishiwata Yuji Tsurumi Jun Itoh Kiyotaka Sato Ryuichi Katakura Takashi Yoshimoto Jun Hatazawa Masatoshi Ito Tatsuo Ido 《Journal of neuro-oncology》1995,23(1):53-61
Summary Positron emission tomography was used to investigate the metabolism of nucleic acids by18F-fluoro-2-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 ± 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 ± 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism. 相似文献
72.
Tanabe T Suzuki S Shimakawa S Yamashiro K Tamai H 《No to hattatsu. Brain and development》1999,31(1):14-20
Lidocaine was administered intravenously as a substitute for diazepam, to 12 patients with status epilepticus or clustering seizures aged 26 days to 11 years. The medication was very effective in 3 cases with acute convulsions, which disappeared immediately after infusion of lidocaine without relapse. The medication was effective only temporarily in 4 patients; they experienced relapsing seizures during drip infusion of lidocaine intravenously for maintenance. All the relapsing seizures were secondarily generalized ones with diffuse ictal discharges. In 2 cases of localization-related epilepsy, complex partial seizures evolved to secondarily generalized seizures immediately after administration of lidocaine. It must be noticed that in a relatively large number of cases lidocaine is ineffective or even harmful. 相似文献
73.
Anterior Transhepatic Approach for Isolated Resection of the Caudate Lobe of the Liver 总被引:15,自引:4,他引:11
Junji Yamamoto Tomoo Kosuge Kazuaki Shimada Susumu Yamasaki Tadatoshi Takayama Masatoshi Makuuchi 《World journal of surgery》1999,23(1):97-101
RID=" ID=" <E5>Correspondence to:</E5> J. Yamamoto, M.D. 相似文献
74.
Activation of the reticulothalamic cholinergic pathway by the major metabolites of aniracetam 总被引:3,自引:0,他引:3
The aim of the study was to further investigate the effects of aniracetam, a cognition enhancer, and its metabolites on the brain cholinergic system. We measured choline acetyltransferase activity and acetylcholine release using in vivo brain microdialysis in stroke-prone spontaneously hypertensive rats (SHRSP). The enzyme activity in the pons–midbrain and hippocampus, and basal acetylcholine release in the nucleus reticularis thalami were lower in SHRSP than in age-matched Wistar Kyoto rats, indicating central cholinergic deficits in SHRSP. Repeated treatment of aniracetam (50 mg/kg p.o.×11 for 6 days) preferentially increased the enzyme activity in the thalamus, whereas decreased it in the striatum. Among the metabolites of aniracetam, local perfusion of N-anisoyl-γ-aminobutyric acid (GABA, 0.1 and/or 1 μM) and p-anisic acid (1 μM) into the nucleus reticularis thalami, dorsal hippocampus and prefrontal cortex of SHRSP produced a significant but delayed increase of acetylcholine release. We failed, however, to find any effect of aniracetam itself. A direct injection of N-anisoyl-GABA (1 nmol) into the pedunculopontine tegmental nucleus of SHRSP enhanced the release in the nucleus reticularis thalami. Thus, these data prove that aniracetam can facilitate central cholinergic neurotransmission via both metabolites. Based on its pharmacokinetic profile, N-anisoyl-GABA may contribute to the clinical effects of aniracetam, mainly by acting on the reticulothalamic cholinergic pathway. 相似文献
75.
Role of Ca2+-activated K+ channels in acetylcholine-induced dilatation of the basilar artery in vivo 下载免费PDF全文
Takanari Kitazono Setsuro Ibayashi Tetsuhiko Nagao Kenichiro Fujii Masatoshi Fujishima 《British journal of pharmacology》1996,120(1):102-106
- We tested the hypothesis that activation of large conductance calcium-activated potassium channels is involved in dilator responses of the basilar artery to acetylcholine in vivo. Using a cranial window in anaesthetized rats, we examined responses of the basilar artery to acetylcholine.
- Topical application of acetylcholine (10−6 and 10−5 M) increased diameter of the basilar artery from 238±7 μm to 268±7 and 288±7 μm, respectively (P<0.05 vs. baseline diameter). Iberiotoxin (10−8 M), an inhibitor of large conductance calcium-activated potassium channels, did not affect baseline diameter of the basilar artery. In the presence of 10−8 M iberiotoxin, 10−6 and 10−5 M acetylcholine increased diameter of the basilar artery from 239±7 μm to 246±7 and 261±7 μm, respectively. Thus, iberiotoxin attenuated acetylcholine-induced dilatation of the basilar artery (P<0.05).
- Sodium nitroprusside (10−7 and 10−6 M) increased diameter of the basilar artery from 242±9 μm to 310±12 and 374±13 μm, respectively (P<0.05 vs. baseline diameter). In the presence of iberiotoxin (10−8 M), sodium nitroprusside (10−7 and 10−6 M) increased diameter of the basilar artery from 243±6 μm to 259±9 and 311±12 μm, respectively. Thus, iberiotoxin attenuated dilator responses of the basilar artery to sodium nitroprusside (P<0.05).
- Iberiotoxin partly inhibited dilator responses of the basilar artery to forskolin, a direct activator of adenylate cyclase, but did not affect vasodilatation produced by levcromakalim, a potassium channel opener.
- These results suggest that dilator responses of the basilar artery to acetylcholine and sodium nitroprusside are mediated, in part, by activation of large conductance calcium-activated potassium channels. Because both acetylcholine and sodium nitroprusside have been shown to activate guanylate cyclase via nitric oxide, activation of large conductance calcium-activated potassium channels may be one of the major mechanisms by which cyclic GMP causes dilatation of the basilar artery in vivo.
76.
77.
Endocrine surgeons have had an important role in the management of hyperthyroidism due to either Graves' disease or toxic
nodule(s). Since alternative treatments such as antithyroid drugs or radioiodine are also available, the decision-making for
management should be based on clear assessment of advantages and limitations of each of the treatment options. Surgery provides
rapid resolution of these conditions, and cure rates are high, although it may be associated with perioperative complications
and postoperative thyroid dysfunction. The authors' experience in the surgical treatment of hyperthyroidism and a review of
the recent literature are outlined in this report. 相似文献
78.
Cole W. Flanagan M.D. John R. Parker M.D. Robert S. Mannel M.D. K.W. Min M.D. Masatoshi Kida M.D. 《Gynecologic oncology》1997,66(3):515-518
Background.Extragonadal endodermal sinus tumors arising in the external genitalia represent an exceedingly rare malignancy in women. Six cases of endodermal sinus tumors of the vulva have been reported to date, with three cases failing to respond to conservative surgery and vincristine-based chemotherapy. We report a seventh case of vulvar endodermal sinus tumor that was treated with radical surgery and platinum-based chemotherapy.Case.RT is an 18-year-old female who presented with a vulvar mass that was diagnosed as endodermal sinus tumor at the time of biopsy. She was subsequently treated with modified radical vulvectomy and ipsilateral groin lymphadenectomy, followed by bleomycin, etoposide, and cisplatin chemotherapeutic regimen. She has since remained free of disease for 18 months as evidenced by serum α-fetoprotein and physical exam at 18 months.Conclusions.Vulvar endodermal sinus tumors represent a very small number of germ cell tumors in women. Based on the previous accounts, this disease appears to be more fatal than endodermal sinus tumor arising at other sites. These tumors also have a predilection for local metastasis. Due to the previous accounts, we chose to treat this patient with radical surgery and platinum-based chemotherapy. This treatment regimen has resulted in a disease-free state for 18 months. 相似文献
79.
Kazuhiko Ogawa Takafumi Toita Yasumasa Kakinohana Keiichiro Yamaguchi Koichi Miyagi Toshihiko Kinjyo Katsumi Yamashiro Satoshi Sawada 《International journal of clinical oncology / Japan Society of Clinical Oncology》1997,2(2):67-72
Background This retrospective study analyzed the outcome in patients with intracranial germ-cell tumors to determine whether tumor response
during radiation therapy can predict achievement of primary local control with radiation therapy alone.
Methods Between 1983 and 1993, 22 patients with untreated primary intracranial germ cell tumors received a total whole brain radiation
dose of between 18 Gy and 45 Gy (mean 31.3 Gy) with or without a localized field of 10 to 36.4 Gy (mean, 22.4 Gy), or local
irradiation only (1 patient). In 10 patients with pineal tumor only, who were treated first with radiation therapy, tumor
response to radiation therapy was evaluated using computed tomography (CT) (at baseline, and approximately 20 Gy and 50 Gy).
Areas of calcification in the tumor were subtracted from total tumor volume. Follow-up time ranged from 2 to 12 years.
Results Five-year actuarial survival rates for patients with germinoma were 71%, 100% for patients with a teratoma component, and
100% for patients without histologic verification. Patients with germinomas or tumors suspected of being germinomas who were
given more than 50 Gy had no local relapse. There was no correlation between primary local control by radiation therapy alone
and initial tumor volume. The rate of tumor volume response to irradiation assesed by CT was significantly different in those
patients who relapsed compared to those who did not relapse
Conclusion Tumor response during radiation therapy using CT was considered to be predictive of primary local control with radiation therapy
alone. 相似文献
80.
Pure red cell aplasia and myasthenia gravis with thymoma: a case report and review of the literature 总被引:3,自引:0,他引:3
Mizobuchi S; Yamashiro T; Nonami Y; Yamamoto A; Kume M; Nakaya H; Sawada T; Taguchi H; Moriki T; Ogoshi S 《Japanese journal of clinical oncology》1998,28(11):696-701
A case of pure red cell aplasia (PRCA), myasthenia gravis (MG) and thymoma
is reported. A 70-year-old woman presented with severe anemia. She had been
diagnosed as having MG 8 years earlier and her symptoms were adequately
controlled with ambenonium chloride. When she visited our hospital, her
hematocrit was 13.7% with a hemoglobin concentration of 4.7 g/dl and her
reticulocyte counts were persistently abnormal at 0.1%. Although both
direct and indirect Coombs' tests were positive, there was no evidence of
hemolysis. Routine screening tests for other etiologies of anemia were
negative. Serological tests for anti-DNA and anti-acetylcholine receptor
antibodies gave positive results. A bone marrow examination revealed severe
erythroid hypoplasia. PRCA was diagnosed and the patient was treated with
periodic transfusions. A lateral view chest roentgenogram and a computed
tomography scan of the thorax showed the presence of an anterior
mediastinal mass which was suspected to be thymoma. The patient underwent
thymothymectomy and the tumor was diagnosed as a thymoma. Although the
patient received no treatment for MG and PRCA after surgery, her
hematological test results rapidly improved and she was discharged from the
hospital on the 29th postoperative day. At that time, her hematocrit was
33.2%, her hemoglobin concentration was 10.0 g/dl, her peripheral
reticulocyte level was 1.8% and her left partial ptosis had improved. She
is doing well, 9 months after surgery. For a patient to remain in remission
without treatment for PRCA and MG after thymothymectomy is extremely rare.
相似文献