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排序方式: 共有127条查询结果,搜索用时 31 毫秒
51.
Shaheeda Mohamed MPH MRCOphth Gabriel M Leung MD Carmen KM Chan FRCSEd Timothy YY Lai MD Vincent YW Lee FRCS David TL Liu MRCS Kenneth KW Li MRCS Patrick SH Li FCOphth Dennis SC Lam MD 《Clinical & experimental ophthalmology》2009,37(6):602-608
Purpose: To identify factors associated with variability in anatomical and functional response of diabetic macular oedema (DMO) after 4 mg of intravitreal triamcinolone acetonide (ivTA), and for recurrence of macular oedema.
Design: Pooled analysis of individual data from two randomized controlled trials.
Methods: This was a multicentre study involving 107 eyes with DMO administered 4 mg ivTA. Predictive factors for response to treatment were evaluated with linear regression analysis. Factors associated with time to recurrence of oedema were studied with Cox proportional hazards modelling. Main outcome measures were maximum improvement in optical coherence tomography (OCT)-measured central foveal thickness (CFT) and best-corrected visual acuity (BCVA), final CFT and BCVA at 12 months and time to oedema recurrence.
Results: Greater reduction of retinal thickening occurred in eyes with worse baseline thickening ( P < 0.001). There was also greater improvement of visual acuity in eyes with poorer preoperative BCVA levels ( P < 0.001). Age, duration of oedema and previous macular laser treatment had no significant effect on maximal BCVA or CFT improvement. Eyes given 4 mg triamcinolone alone were more likely to develop recurrence of oedema at 12 months than those given a combination of 4 mg triamcinolone plus sequential laser (hazard ratio 2.60 [95% confidence interval: 1.45–4.67]).
Conclusion: Baseline OCT-measured retinal thickening and BCVA are important predictors of maximal anatomical and functional response of DMO to ivTA, respectively. Combination treatment strategy using sequential laser therapy may have a role in delaying recurrence of oedema after triamcinolone. 相似文献
Design: Pooled analysis of individual data from two randomized controlled trials.
Methods: This was a multicentre study involving 107 eyes with DMO administered 4 mg ivTA. Predictive factors for response to treatment were evaluated with linear regression analysis. Factors associated with time to recurrence of oedema were studied with Cox proportional hazards modelling. Main outcome measures were maximum improvement in optical coherence tomography (OCT)-measured central foveal thickness (CFT) and best-corrected visual acuity (BCVA), final CFT and BCVA at 12 months and time to oedema recurrence.
Results: Greater reduction of retinal thickening occurred in eyes with worse baseline thickening ( P < 0.001). There was also greater improvement of visual acuity in eyes with poorer preoperative BCVA levels ( P < 0.001). Age, duration of oedema and previous macular laser treatment had no significant effect on maximal BCVA or CFT improvement. Eyes given 4 mg triamcinolone alone were more likely to develop recurrence of oedema at 12 months than those given a combination of 4 mg triamcinolone plus sequential laser (hazard ratio 2.60 [95% confidence interval: 1.45–4.67]).
Conclusion: Baseline OCT-measured retinal thickening and BCVA are important predictors of maximal anatomical and functional response of DMO to ivTA, respectively. Combination treatment strategy using sequential laser therapy may have a role in delaying recurrence of oedema after triamcinolone. 相似文献
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Use of film duplicator to lighten dark radiographs 总被引:1,自引:0,他引:1
55.
Oxidative damage is a proposed mechanism of asbestos-induced
carcinogenesis, but the detection of oxidative DNA lesions in target cells
of asbestos-induced mesothelioma has not been examined. In studies here,
DNA was isolated from both rat pleural mesothelial (RPM) cells and a human
mesothelial cell line (MET5A) after exposure in vitro to crocidolite
asbestos at various concentrations. DNA was then examined for formation of
8-hydroxydeoxyguanosine (8-OHdG) at 24, 48 and 72 h using HPLC with
electrochemical detection. In addition, steady- state mRNA levels of
manganese-containing superoxide dismutase (MnSOD) were assessed as an
indication of oxidative stress. Whereas RPM cells showed dose-dependent and
significant increases in 8-OHdG formation in response to crocidolite
asbestos or iron-chelated crocidolite fibers (but not after exposure to
glass beads), MET5A cells showed decreases in 8-OHdG. Both cell types
exhibited elevations in message levels of MnSOD. In comparison with human
MET5A cells, RPM cells exhibited increased cytotoxicity and apoptosis in
response to asbestos, as documented by cell viability assays and flow
cytometry analysis using propidium iodide. Results in RPM cells indicate
that asbestos causes oxidative damage that may result in potentially
mutagenic lesions in DNA and/or apoptosis, despite compensatory increases
in expression of an antioxidant enzyme.
相似文献
56.
川续断的化学成分研究 总被引:14,自引:0,他引:14
从川续断(Dosacus asper Wall)的根中分得六个化合物(Ⅰ~Ⅵ)。Ⅰ,Ⅱ,Ⅲ和Ⅵ分别鉴定为蔗糖、胡萝卜甙、β-谷甾醇和akebia saponin D.Ⅵ和Ⅴ为新化合物,根据光谱分析和化学方法证明其结构分别为3-O-(4-O-乙酰基)-α-L-吡喃阿拉伯糖常春藤皂甙元28-O-β-D-吡喃葡萄糖-(1→6)-β-D-吡喃葡萄糖酯甙和3-O-α-L-吡喃阿拉伯糖齐墩果酸28-O-β-D-吡喃葡萄糖-(1→6)-β-D-吡喃葡萄糖酯甙。 相似文献
57.
本文报道分别定量检测人血浆中(+),(-)棉酚含量的高效液相色谱测定法。棉酚人血浆样品经乙腈沉淀蛋白后,上清液加手性试剂——(+)-2-氨基-1-丁醇,75℃加热45min。反应液加NaCl进行溶剂反混合处理后,取乙腈层50~100μl进样。选用ODS固定相,紫外254nm检测,以甲醇—异丙醇—水—磷酸(80:20:20:0.1 V/V)为流动相,流速1.2ml/min时,(+),(-) 棉酚衍生物的保留时间分别为4.2,7.7 min。检测人血浆中(+),(-)棉酚在0.125~2.0μg/ml范围内呈线性关系。棉酚回收率达94~98%,此法已用于棉酚的临床血药浓度监测和动物实验研究。 相似文献
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59.
Brenda R Hemmelgarn Louise Moist Rachel M Pilkey Charmaine Lok Marc Dorval Paul YW Tam Murray J Berall Martine LeBlanc Edwin B Toffelmire Braden J Manns Nairne Scott-Douglas 《BMC nephrology》2006,7(1):1-8
Background
Nocturnal hemodialysis (NHD) is an alternative to conventional three times per week hemodialysis (CvHD) and has been reported to improve several health outcomes. To date, no randomized controlled trial (RCT) has compared NHD and CvHD. We have undertaken a multi-center RCT in hemodialysis patients comparing the effect of NHD to CvHD on left ventricular (LV) mass, as measured by cardiac magnetic resonance imaging (cMR).Methodology/design
All patients in Alberta, Canada, expressing an interest in performing NHD are eligible for the study. Patients enrolled in the study will be randomized to either NHD or CvHD for a six month period. All patients will have a full clinical assessment, including collection of biochemical and cMR data at baseline and at 6 months. Both groups of patients will be monitored biweekly to optimize blood pressure (BP) to a goal of <130/80 mmHg post-dialysis using a predefined BP management protocol. The primary outcome is change in LV mass, a surrogate marker for cardiac mortality, measured at baseline and 6 months. The high sensitivity and reproducibility of cMR facilitates reduction of the required sample size and the time needed between measures compared with echocardiography. Secondary outcomes include BP control, anemia, mineral metabolism, health-related quality of life, and costs.Discussion
To our knowledge, this study will be the first RCT evaluating health outcomes in NHD. The impact of NHD on LV mass represents a clinically important outcome which will further elucidate the potential benefits of NHD and guide future clinical endpoint studies. 相似文献60.
SARS: prognosis, outcome and sequelae 总被引:1,自引:0,他引:1
Severe acute respiratory syndrome (SARS) is associated with considerable morbidity and mortality in the acute phase. Worldwide case fatality rate is 11% (range 7 to 27%) for the most severely affected regions. Several adverse prognostic factors have been identified, including advanced age, presence of comorbidity, higher lactose dehydrogenase levels and initial neutrophil count, but the impact of viral and other host factors on outcome is unknown. Published data on sequelae of SARS are limited. Clinical follow-up of patients who recovered from SARS has demonstrated radiological, functional and psychological abnormalities of varying degrees. In the early rehabilitation phase, many complained of limitations in physical function from general weakness and/or shortness of breath. In a small series of subjects who underwent CT scan of the chest, over half showed some patchy changes consistent with pulmonary fibrosis. Lung function testing at 6–8 weeks after hospital discharge showed mild or moderate restrictive pattern consistent with muscle weakness in 6–20% of subjects. Mild decrease in carbon monoxide diffusing capacity was detected in a minority of subjects. Preliminary evidence suggests that these lung function abnormalities will improve over time. Psychobehavioural problems of anxiety and/or depression were not uncommon in the early recovery phase, and improved over time in the majority of patients. Avascular necrosis of the hip has been reported as another complication. The long-term sequelae of SARS are still largely unknown. It is important to follow up these patients to detect and appropriately manage any persistent or emerging long-term sequelae in the physical, psychological and social domains. 相似文献