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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
The liver first pass effects and bile concentrations of (-)-, (+)- and (+/-)-praziquantel in rabbits
Praziquantel (PQT) is a racemic mixture. Intragastric gavage of (-)-, (+)- and (+/-)-PQT 100 mg/kg were used to study the liver first pass effects in rabbits. HPLC was used to determine the concentration of each compound in the portal and systemic circulation, and in the bile within 4h. The results showed that all drugs were absorbed rapidly from the gut into the portal vein. The serum concentration in the portal vein were similar. However, over 90% of PQT and its enantiomers were extracted in the first passage through the liver. Intrinsic metabolic clearances of the liver of (-)-, (+)- and (+/-)-PQT were 50.3, 174.4 and 52.6 L/h, respectively. The serum concentrations of the three drugs markedly decreased in the systemic circulation, especially that of (+)-PQT. The AUC of (+)-PQT was apparently lower than that of (-)- or (+/-)-PQT. From these results, it is assumed that the first pass effects of PQT and its enantiomers in the liver are pronounced and most likely stereoselective. Also, unchanged PQT and its enantiomers were found in the bile of the rabbits. 相似文献
992.
993.
Zhang Mei-ying张美英and Zhang Xiao-lou张晓楼Depart''ment of Ophthalmol ogy Tongren Hospital Beijing 《中华医学杂志(英文版)》1987,100(8):677-678
A perusal of the medical literature re-
vealod only one case of giant nonmetallic in
traocular foreign body, 15x11x7 mm, removed
in China However, no mention was made of
the operative result of the wounded eye in the
report. Usually after removal of intraocular
foriegn bodies, especially the giant ones, the
eyeball becomes inevitably atrophied, thus it
has to be enucleated soon after operation.
We removed a giant intraocular metallic
foreign body, measuring 18.1x9x1.5 mm and
weighing 0.24 g, from the left eye of a patient
at our clinic. Follow-up l year after operation
found that the eyeball of the affected eye was
good in appearance with preservation of partial
vision. 相似文献
994.
995.
996.
The effect of a carbon dioxide pneumoperitoneum on rabbit follicular oocytes and early embryonic development 总被引:1,自引:0,他引:1
C Mastroyannis Y Hosoi Y Yoshimura S J Atlas E E Wallach 《Fertility and sterility》1987,47(6):1025-1030
The effect of a carbon dioxide (CO2) pneumoperitoneum and its duration on rabbit follicular oocytes was assessed by evaluating fertilization and subsequent embryonic development rates. CO2 may cross the plasma membrane and form carbonic acid, which liberates H+, thus lowering the intracellular pH. There were no significant differences in arterial pH and [HCO3-] between CO2 and air treatment groups, whereas arterial pCO2 and pO2 were significantly increased in the CO2 treatment group. We found that the duration of pneumoperitoneum, irrespective of type of gas used, was negatively correlated with success of embryonic development. These findings necessitate that more attention be given to the gas used for creation of a pneumoperitoneum during egg retrieval for in vitro fertilization and an attempt be made to minimize duration of the pneumoperitoneum. 相似文献
997.
A 16 year old girl with post-streptococcal glomerulonephritis developed acute rheumatic fever 19 days afterwards. Previous publications on concurrent post-streptococcal glomerulonephritis and acute rheumatic fever are reviewed. 相似文献
998.
999.
1000.
Hon Y. Chan Frederick J. Meyers Jerry P. Lewis 《Cancer chemotherapy and pharmacology》1987,20(3):265-266
Summary In a study of 11 adult patients with acute nonlymphocytic leukemia (ANLL), infusion therapy with high-dose VP-16 and intermediate-dose cytosine arabinoside was administered. Response was assessed with reference to bone marrow aspirations performed on days 1; 12, 13, or 14; and 21 of treatment. All 7 of the patients with ANLL in relapse achieved marrow hypoplasia, and 3 of them achieved complete response. LFTs were elevated in most patients but no evidence of hepatocellular necrosis was observed. It is concluded that the value of VP-16 in ANLL may have been underestimated in the past because of inadequate dosing.Abbreviations ANLL
acute nonlymphocytic leukemia
- CGL
chronic granulocytic leukemia
- DNR
daunorubicin
- VNC
vincristine
- ID
Ara-C, intermediate-dose Ara-C (500 mg/m2 for 12 doses)
- HD
Ara-C, high-dose Ara-C (3 g/m2 for 12 doses)
- SGGT
serum glutamic transaminase
- LDH
lactic dehydrogenase
- SGOT
serum glutamic oxaloacetic transaminase 相似文献