Superlattice-like structure and enhanced ferroelectric properties of intergrowth Aurivillius oxides

Aurivillius oxides with an intergrowth structures have been receiving increasing interest because of their special structures and potential outstanding ferroelectric properties. In this work, Bi₃LaTiNbFeO₁₂–Bi₅Ti₃FeO₁₅ and Bi₃TiNbO₉–Bi₃LaTiNbFeO₁₂ compounds were successfully synthetised using a simple solid-state reaction method. X-Ray diffraction patterns and scanning transmission electron microscopy high angle annular dark field (STEM-HAADF) images confirm the 2–3 and the 3–4 intergrowth structures in Bi₃TiNbO₉–Bi₃LaTiNbFeO₁₂ and Bi₃LaTiNbFeO₁₂–Bi₅Ti₃FeO₁₅ compounds, respectively. A superlattice-like distortion in these oxides was proposed resulting from the combination of sub-lattices with different a and b parameters, which was validated by XRD refinements and Raman spectra. Polarization-electric field tests and pulsed polarization positive-up negative-down measurements demonstrate that such superlattice-like structures can effectively enhance the intrinsic ferroelectric polarization and coercive field of these oxides, especially when compared with their component oxides Bi₃TiNbO₉, Bi₃LaTiNbFeO₁₂ and Bi₅Ti₃FeO₁₅. Simultaneously, ferroelectric Curie temperatures of Bi₃TiNbO₉–Bi₃LaTiNbFeO₁₂ and Bi₃LaTiNbFeO₁₂–Bi₅Ti₃FeO₁₅ oxides are lowered because of the internal stress in the superlattice-like structure. Nevertheless, the paramagnetism of the samples is hardly influenced by their structure, while mainly related to their iron content, in which iron has a similar effective magnetic moment around 3.4–3.9.

Aurivillius oxides with an intergrowth structures have been receiving increasing interest because of their special structures and potential outstanding ferroelectric properties.     

全膝表面置换术117例患者性别差异及原因分析

观察膝关节置换（total kneearthroplasty,TKA）患者性别差异并分析产生差异的原因。回顾性研究我院骨科117例TKA患者的性别差异、平均年龄、患病时间及各自骨赘比率差异。于我院行全膝表面置换术患者以女性为主,接受全膝表面置换术患者平均年龄男性为67.31±5.43岁,女性为62.45±8.47岁;总病程男性为13.72±6.71年,女性为10.11±5.61年;骨赘所占比率男性为30.43%,女性为17.02%。我院膝关节置换患者性别差异明显,影响因素较多,主要有骨关节炎发病比率、疾病耐受程度、社会心理学差异及其他因素。     

橡皮圈腔内牵拉法在内镜黏膜下剥离术中辅助价值研究

目的　评价橡皮圈腔内牵拉法用于内镜黏膜下剥离术（endoscopic submucosal dissection,ESD） 中的有效性及安全性。方法　纳入2016年1月—2019年12月因直肠内分泌瘤就诊于首都医科大学附属北京友谊医院的49例患者,其中2016年1月—2018年5月行常规ESD的患者32例（非牵拉组）,2018年6月—2019年12月行橡皮圈腔内牵拉ESD的患者17例（牵拉组）,比较2组患者基本信息、ESD手术时间、并发症等指标。结果　牵拉组和非牵拉组在年龄、性别及病变大小方面差异均无统计学意义（P均>0.05）。牵拉组ESD操作时间为（13.76±5.71） min,非牵拉组ESD操作时间为（22.99±10.32） min,两者差异有统计学意义（t=-3.408,P=0.001）。牵拉组未发生术后并发症,非牵拉组有3例出现穿孔,但穿孔发生率差异无统计学意义（P=0.542）。结论　橡皮圈腔内牵拉法辅助ESD,可以安全完成ESD操作并有效提高剥离效率。     

江苏省医院非技术服务质量评价指标体系的研究

非技术性服务质量对于现代医院来讲意义重大。评价指标体系是对其进行评价而改进其质量为前提和关键。该研究从指标体系的构建、指标体系的确立以及指标体系的考核三个方面研究了江苏省医院非技术服务质量评价指标体系。     

中西医结合治疗脑卒中后焦虑障碍45例临床研究

目的：观察中西医结合治疗脑卒中后焦虑障碍（PSAD）的临床疗效。方法；对45例PSAD病人于治疗前后进行SAS测评，并对所获资料进行统计学分析。结果：焦虑症状消失率为88．89％；SAS标准分均数值经治疗后明显下降，有统计学意义（P＜0．001）；各项目所引起的症状得分均数值亦明显下降。结论：中西医结合治疗PSAD可取得较好疗效。     

青海省鼠疫患者血清抗体谱研究

目的研究在鼠疫感染过程中,患者对鼠疫耶尔森菌产生体液免疫反应的规律.寻找鼠疫菌新的具有免疫原性的蛋白。方法利用鼠疫耶尔森菌重要毒力相关蛋白芯片对鼠疫患者的血清抗体谱进行检测。结果利用含145个鼠疫耶尔森菌蛋白质的蛋白芯片。共检测到鼠疫患者血清中29个蛋白的抗体。其中13种蛋白的抗体在患者体内明显上升,除已知的8个具有免疫原性的蛋白外,发现了鼠疫菌5个新的具有免疫原性的蛋白(SycE、SycH、OmpA、pH6与YPO2098)。结论这5个新的具有免疫原性的蛋白将是下一步鼠疫疫苗研究的靶点。     

Association of bone marrow fibrosis with inferior survival outcomes in chronic myelomonocytic leukemia

The impact of bone marrow fibrosis grade on the prognosis of patients with chronic myelomonocytic leukemia (CMML) remains controversial. Therefore, we examined the records of 82 patients diagnosed with CMML at our institution and summarized baseline characteristics and molecular profiles by subgroups of absent or mild (grades 0/1) and moderate (grade 2) fibrosis. Cox proportional hazards models were constructed to assess the prognostic significance of fibrosis grade. Grade 2 fibrosis was identified in 63 patients (76.8%), grade 1 in 16 patients (19.5%), and grade 0 in 3 patients (3.7%). Grade 2 fibrosis was associated with reduced hemoglobin levels (median 9.75 vs 11.0 g/dL in grade 0/1; p?=?0.04) and increased percentages of ringed sideroblasts (7.5 vs 0%; p?=?0.008). In multivariable analysis, grade 2 fibrosis was an independent predictor of poor overall survival (OS; 95% CI 1.32–6.35; HR 2.90; p?=?0.008), but not event-free survival (EFS; 95% CI 0.62–2.67; HR 1.28; p?=?0.50). Absolute neutrophil count (ANC) was found to impact OS (95% CI 1.01–1.09; HR 1.05; p?=?0.009), while both ANC (95% CI 1.00–1.07; HR 1.04; p?=?0.04) and peripheral blood blast percentage (95% CI 1.02–1.32; HR 1.16; p?=?0.02) impacted EFS. These results implicate fibrosis grade is an important indicator of prognosis, with high-grade fibrosis predicting inferior survival. Given the prevalence of marrow fibrosis in CMML, fibrosis grading should be incorporated into prognostic assessment and therapeutic decision-making.     

中药扶正抗癌方治疗中、晚期消化道肿瘤160例临床观察

14年来，以中药扶正抗癌方（自拟）治疗中、晚期消化道肿瘤160例，收到了较为满意的疗效。患者症状改善，血象升高，免疫指标提升，癌胚抗原含量下降．患者的体质增强，体重增加．其它疾病少发等，有的患者癌灶缩小，甚至消失，绝大多数的患者经治疗后生存期得以延长。